Accession	MF_01576
Dates	22-NOV-2006 (Created) 7-JUN-2008 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01576; [distribution of match scores in UniProtKB];[seed alignment for MF_01576]

Identifier

FOLD

Protein name

RecName: Full=Bifunctional protein folD; RecName: Full=Methylenetetrahydrofolate dehydrogenase; EC=1.5.1.5; RecName: Full=Methenyltetrahydrofolate cyclohydrolase; EC=3.5.4.9;

Gene name

folD

FUNCTION: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate (By similarity).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.

CATALYTIC ACTIVITY: 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.

PATHWAY: One-carbon metabolism; tetrahydrofolate pathway.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

PROSITE	PS00766; THF_DHG_CYH_1; 1; PS00767; THF_DHG_CYH_2; 1;
Pfam	PF00763; THF_DHG_CYH; 1; PF02882; THF_DHG_CYH_C; 1;
PRINTS	PR00085; THFDHDRGNASE; 1;

Amino-acid biosynthesis, Histidine biosynthesis, Hydrolase, Methionine biosynthesis, Multifunctional enzyme, NADP, One-carbon metabolism, Oxidoreductase, Purine biosynthesis.

GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity.
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity.

Size range:	269-320 amino acids
Related UniRules:	None
Template:	P24186 (FOLD_ECOLI); P51696 (FOLD_PHOPO): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in ACIAD, ARTAT, BORPA, BORPE, COLP3, DEHE1, DEIGD, DESHY, FRAAA, FRASC, GEOMG, GEOSL, HALMA, LACH4, LACJO, MYXXD, NOCSJ, PARDP, PSE14, PSEMY, PSEPG, PSEPK, PSESM, PSEU2, RHIEC, RHILO, RHIME, RHOSR, ROSDO, RUBXD, SACEN, SALAI, SALTO, SILPO, SINMW, SPHWW, STRAW, SYNWW, THICR
Plasmid encoded:	in HALMA, PARDP, RHIEC, RHISN