Accession	MF_00563
Dates	4-JUN-2002 (Created) 26-SEP-2008 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00563_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00563_B]

Predictors

HAMAP; MF_00563_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00563_A]

Identifier

SAHH

Protein name

RecName: Full=Adenosylhomocysteinase; EC=3.3.1.1; AltName: Full=S-adenosyl-L-homocysteine hydrolase; Short=AdoHcyase;

Gene name

ahcY

CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.

COFACTOR: Binds 1 NAD per subunit (By similarity).

PATHWAY: Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the adenosylhomocysteinase family.

Pfam	PF00670; AdoHcyase; 1;
TIGRFAMs	TIGR00936; ahcY; 1;
PROSITE	PS00738; ADOHCYASE_1; 1; PS00739; ADOHCYASE_2; 1;

Cytoplasm, Hydrolase, NAD, One-carbon metabolism.

GO:0004013; Molecular function: adenosylhomocysteinase activity.
GO:0006730; Biological process: one-carbon compound metabolic process.
GO:0005737; Cellular component: cytoplasm.

From: SAHH_RHOCA (P28183)
Key		From		To		Description		Condition		FTGroup
REGION		216		381		NAD binding (By similarity)
BINDING		54		54		Substrate (By similarity)
BINDING		128		128		Substrate (By similarity)
BINDING		189		189		Substrate (By similarity)
BINDING		219		219		Substrate (By similarity)
BINDING		223		223		Substrate (By similarity)

From: SAHH_METJA (Q58783)
Key		From		To		Description		Condition		FTGroup
REGION		174		341		NAD binding (By similarity)
BINDING		123		123		Substrate (By similarity)
BINDING		148		148		Substrate (By similarity)
BINDING		178		178		Substrate (By similarity)
BINDING		182		182		Substrate (By similarity)

Size range:

404-495 amino acids

Size range:

405-437 amino acids

Related UniRules:	None
Template:	P10760 (SAHH_RAT); P28183 (SAHH_RHOCA); Q58783 (SAHH_METJA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None