[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [MRNA] OF 3336-12202 (ISOFORM 4), AND VARIANTS ILE-498; GLU-1201; ARG-1572; MET-2610; SER-2831; MET-3261; HIS-12383; GLU-12679; ILE-19762; ILE-20718; ASN-23807; MET-24980 AND THR-27755.
TISSUE=Skeletal muscle;
PubMed=7569978 [NCBI, ExPASy, EBI, Israel, Japan]
Labeit S.,
Kolmerer B.;
"Titins, giant proteins in charge of muscle ultrastructure and elasticity.";
Science 270:293-296(1995).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, AND VARIANTS PRO-4215 AND PHE-4283.
PubMed=10850961 [NCBI, ExPASy, EBI, Israel, Japan]
Freiburg A.,
Trombitas K.,
Hell W.,
Cazorla O.,
Fougerousse F.,
Centner T.,
Kolmerer B.,
Witt C.,
Beckmann J.S.,
Gregorio C.C.,
Granzier H.,
Labeit S.;
"Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.";
Circ. Res. 86:1114-1121(2000).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY, INTERACTION WITH OBSCN, AND VARIANTS PRO-4215 AND PHE-4283.
PubMed=11717165 [NCBI, ExPASy, EBI, Israel, Japan]
Bang M.-L.,
Centner T.,
Fornoff F.,
Geach A.J.,
Gotthardt M.,
McNabb M.,
Witt C.C.,
Labeit D.,
Gregorio C.C.,
Granzier H.,
Labeit S.;
"The complete gene sequence of titin, expression of an unusual ~700 kDa titin isoform and its interaction with obscurin identify a novel Z-line to I-band linking system.";
Circ. Res. 89:1065-1072(2001).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W.,
Graves T.A.,
Fulton R.S.,
Fulton L.A.,
Pepin K.H.,
Minx P.,
Wagner-McPherson C.,
Layman D.,
Wylie K.,
Sekhon M.,
Becker M.C.,
Fewell G.A.,
Delehaunty K.D.,
Miner T.L.,
Nash W.E.,
Kremitzki C.,
Oddy L.,
Du H.,
Sun H., ![]()
Bradshaw-Cordum H.,
Ali J.,
Carter J.,
Cordes M.,
Harris A.,
Isak A.,
van Brunt A.,
Nguyen C.,
Du F.,
Courtney L.,
Kalicki J.,
Ozersky P.,
Abbott S.,
Armstrong J.,
Belter E.A.,
Caruso L.,
Cedroni M.,
Cotton M.,
Davidson T.,
Desai A.,
Elliott G.,
Erb T.,
Fronick C.,
Gaige T.,
Haakenson W.,
Haglund K.,
Holmes A.,
Harkins R.,
Kim K.,
Kruchowski S.S.,
Strong C.M.,
Grewal N.,
Goyea E.,
Hou S.,
Levy A.,
Martinka S.,
Mead K.,
McLellan M.D.,
Meyer R.,
Randall-Maher J.,
Tomlinson C.,
Dauphin-Kohlberg S.,
Kozlowicz-Reilly A.,
Shah N.,
Swearengen-Shahid S.,
Snider J.,
Strong J.T.,
Thompson J.,
Yoakum M.,
Leonard S.,
Pearman C.,
Trani L.,
Radionenko M.,
Waligorski J.E.,
Wang C.,
Rock S.M.,
Tin-Wollam A.-M.,
Maupin R.,
Latreille P.,
Wendl M.C.,
Yang S.-P.,
Pohl C.,
Wallis J.W.,
Spieth J.,
Bieri T.A.,
Berkowicz N.,
Nelson J.O.,
Osborne J.,
Ding L.,
Meyer R.,
Sabo A.,
Shotland Y.,
Sinha P.,
Wohldmann P.E.,
Cook L.L.,
Hickenbotham M.T.,
Eldred J.,
Williams D.,
Jones T.A.,
She X.,
Ciccarelli F.D.,
Izaurralde E.,
Taylor J.,
Schmutz J.,
Myers R.M.,
Cox D.R.,
Huang X.,
McPherson J.D.,
Mardis E.R.,
Clifton S.W.,
Warren W.C.,
Chinwalla A.T.,
Eddy S.R.,
Marra M.A.,
Ovcharenko I.,
Furey T.S.,
Miller W.,
Eichler E.E.,
Bork P.,
Suyama M.,
Torrents D.,
Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-626 AND 34071-34350 (ISOFORM 3).
TISSUE=Muscle, and Skeletal muscle;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] OF 405-709 (ISOFORMS 1 AND 2).
TISSUE=Heart muscle;
PubMed=8937992 [NCBI, ExPASy, EBI, Israel, Japan]
Gautel M.,
Goulding D.,
Bullard B.,
Weber K.,
Furst D.O.;
"The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers.";
J. Cell Sci. 109:2747-2754(1996).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 2023-2060, AND TISSUE SPECIFICITY.
TISSUE=Heart muscle;
DOI=10.1021/bi00002a021; PubMed=7819249 [NCBI, ExPASy, EBI, Israel, Japan]
Musco G.,
Tziatzos C.,
Schuck P.,
Pastore A.;
"Dissecting titin into its structural motifs: identification of an alpha helix near the N-terminus.";
Biochemistry 34:553-561(1995).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3455-4473, AND VARIANTS PRO-3491; PRO-4215 AND PHE-4283.
PubMed=10051295 [NCBI, ExPASy, EBI, Israel, Japan]
Siu B.L.,
Niimura H.,
Osborne J.A.,
Fatkin D.,
MacRae C.,
Solomon S.,
Benson D.W.,
Seidman J.G.,
Seidman C.E.;
"Familial dilated cardiomyopathy locus maps to chromosome 2q31.";
Circulation 99:1022-1026(1999).
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[9]
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NUCLEOTIDE SEQUENCE [MRNA] OF 9806-12017 (ISOFORM 5).
TISSUE=Heart ventricle;
DOI=10.1023/A:1023410523184; PubMed=12785098 [NCBI, ExPASy, EBI, Israel, Japan]
Greaser M.L.,
Berri M.,
Warren C.M.,
Mozdziak P.E.;
"Species variations in cDNA sequence and exon splicing patterns in the extensible I-band region of cardiac titin: relation to passive tension.";
J. Muscle Res. Cell Motil. 23:473-482(2002).
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[10]
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NUCLEOTIDE SEQUENCE [MRNA] OF 12947-13797.
TISSUE=Embryonic rhabdomyosarcoma;
Behrends U.,
Gotz C.,
Mautner J.;
"Serological identification of rhabdomyosarcoma antigens.";
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
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[11]
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NUCLEOTIDE SEQUENCE OF 14257-14543.
PubMed=8351016 [NCBI, ExPASy, EBI, Israel, Japan]
Gautel M.,
Lakey A.,
Barlow D.P.,
Holmes Z.,
Scales S.,
Leonard K.,
Labeit S.,
Mygland A.,
Gilhus N.E.,
Aarli J.A.;
"Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin.";
Neurology 43:1581-1585(1993).
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[12]
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NUCLEOTIDE SEQUENCE [MRNA] OF 21021-22120, AND NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23754-24284.
PubMed=1582406 [NCBI, ExPASy, EBI, Israel, Japan]
Labeit S.,
Gautel M.,
Lakey A.,
Trinick J.;
"Towards a molecular understanding of titin.";
EMBO J. 11:1711-1716(1992).
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[13]
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NUCLEOTIDE SEQUENCE [MRNA] OF 29701-34350, AND PHOSPHORYLATION.
PubMed=8404852 [NCBI, ExPASy, EBI, Israel, Japan]
Gautel M.,
Leonard K.,
Labeit S.;
"Phosphorylation of KSF motifs in the C-terminal region of titin in differentiating myoblasts.";
EMBO J. 12:3827-3834(1993).
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[14]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33119-34350.
TISSUE=Skeletal muscle;
The German cDNA consortium;
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[15]
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INTERACTION WITH TCAP.
DOI=10.1016/S0014-5793(98)00501-8; PubMed=9645487 [NCBI, ExPASy, EBI, Israel, Japan]
Mues A.,
van der Ven P.F.M.,
Young P.,
Furst D.O.,
Gautel M.;
"Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin.";
FEBS Lett. 428:111-114(1998).
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[16]
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INTERACTION WITH NEB.
DOI=10.1016/S0014-5793(02)03655-4; PubMed=12482578 [NCBI, ExPASy, EBI, Israel, Japan]
Ma K.,
Wang K.;
"Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin.";
FEBS Lett. 532:273-278(2002).
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[17]
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INTERACTION WITH FHL2.
DOI=10.1242/jcs.00181; PubMed=12432079 [NCBI, ExPASy, EBI, Israel, Japan]
Lange S.,
Auerbach D.,
McLoughlin P.,
Perriard E.,
Schafer B.W.,
Perriard J.-C.,
Ehler E.;
"Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.";
J. Cell Sci. 115:4925-4936(2002).
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[18]
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INTERACTION WITH ANK1.
DOI=10.1074/jbc.M209012200; PubMed=12444090 [NCBI, ExPASy, EBI, Israel, Japan]
Kontrogianni-Konstantopoulos A.,
Bloch R.J.;
"The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.";
J. Biol. Chem. 278:3985-3991(2003).
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[19]
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INTERACTION WITH ANKRD1; ANKRD2; ANKRD23 AND CAPN3.
DOI=10.1016/j.jmb.2003.09.012; PubMed=14583192 [NCBI, ExPASy, EBI, Israel, Japan]
Miller M.K.,
Bang M.-L.,
Witt C.C.,
Labeit D.,
Trombitas C.,
Watanabe K.,
Granzier H.,
McElhinny A.S.,
Gregorio C.C.,
Labeit S.;
"The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.";
J. Mol. Biol. 333:951-964(2003).
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[20]
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INTERACTION WITH CRYAB.
DOI=10.1074/jbc.M307473200; PubMed=14676215 [NCBI, ExPASy, EBI, Israel, Japan]
Bullard B.,
Ferguson C.,
Minajeva A.,
Leake M.C.,
Gautel M.,
Labeit D.,
Ding L.,
Labeit S.,
Horwitz J.,
Leonard K.R.,
Linke W.A.;
"Association of the chaperone alphaB-crystallin with titin in heart muscle.";
J. Biol. Chem. 279:7917-7924(2004).
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[21]
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INTERACTION WITH TRIM63 AND TRIM55.
DOI=10.1016/j.jmb.2005.05.021; PubMed=15967462 [NCBI, ExPASy, EBI, Israel, Japan]
Witt S.H.,
Granzier H.,
Witt C.C.,
Labeit S.;
"MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.";
J. Mol. Biol. 350:713-722(2005).
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[22]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-8490, AND MASS SPECTROMETRY.
DOI=10.1038/sj.emboj.7601384; PubMed=17053785 [NCBI, ExPASy, EBI, Israel, Japan]
Wang Y.,
Du D.,
Fang L.,
Yang G.,
Zhang C.,
Zeng R.,
Ullrich A.,
Lottspeich F.,
Chen Z.;
"Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.";
EMBO J. 25:5058-5070(2006).
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[23]
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INTERACTION WITH LAMIN, AND SUBCELLULAR LOCATION.
DOI=10.1242/jcs.02728; PubMed=16410549 [NCBI, ExPASy, EBI, Israel, Japan]
Zastrow M.S.,
Flaherty D.B.,
Benian G.M.,
Wilson K.L.;
"Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.";
J. Cell Sci. 119:239-249(2006).
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[24]
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REVIEW.
DOI=10.1152/ajpheart.00816.2005; PubMed=16537787 [NCBI, ExPASy, EBI, Israel, Japan]
Hoshijima M.;
"Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures.";
Am. J. Physiol. 290:H1313-H1325(2006).
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[25]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33938 AND SER-33942, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5304 AND SER-5306 (ISOFORM 6), AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr070152u; PubMed=17924679 [NCBI, ExPASy, EBI, Israel, Japan]
Yu L.-R.,
Zhu Z.,
Chan K.C.,
Issaq H.J.,
Dimitrov D.S.,
Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
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[26]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22525 AND SER-22534, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H.,
Horn D.M.,
Tang N.,
Mathivanan S.,
Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
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[27]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9203 AND THR-9207, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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[28]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4065 AND SER-4068, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K.,
Sugiyama N.,
Kyono Y.,
Tomita M.,
Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
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[29]
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STRUCTURE BY NMR OF 33483-33579.
DOI=10.1016/S0969-2126(01)00170-8; PubMed=7613868 [NCBI, ExPASy, EBI, Israel, Japan]
Pfuhl M.,
Pastore A.;
"Tertiary structure of an immunoglobulin-like domain from the giant muscle protein titin: a new member of the I set.";
Structure 3:391-401(1995).
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[30]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 32172-32489, FUNCTION, ENZYME REGULATION, INTERACTION WITH CALM, PHOSPHORYLATION AT TYR-32341, AND MUTAGENESIS OF LYS-32207 AND TYR-32341.
DOI=10.1038/27603; PubMed=9804419 [NCBI, ExPASy, EBI, Israel, Japan]
Mayans O.,
van der Ven P.F.M.,
Wilm M.,
Mues A.,
Young P.,
Furst D.O.,
Wilmanns M.,
Gautel M.;
"Structural basis for activation of the titin kinase domain during myofibrillogenesis.";
Nature 395:863-869(1998).
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[31]
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STRUCTURE BY NMR OF 22283-22385.
DOI=10.1016/S0969-2126(98)00129-4; PubMed=9782056 [NCBI, ExPASy, EBI, Israel, Japan]
Goll C.M.,
Pastore A.,
Nilges M.;
"The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains.";
Structure 6:1291-1302(1998).
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[32]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2073-2171, AND DISULFIDE BOND.
DOI=10.1016/S0969-2126(01)00591-3; PubMed=11525170 [NCBI, ExPASy, EBI, Israel, Japan]
Mayans O.,
Wuerges J.,
Canela S.,
Gautel M.,
Wilmanns M.;
"Structural evidence for a possible role of reversible disulphide bridge formation in the elasticity of the muscle protein titin.";
Structure 9:331-340(2001).
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[33]
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X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 1-196 IN COMPLEX WITH TCAP.
DOI=10.1038/nature04343; PubMed=16407954 [NCBI, ExPASy, EBI, Israel, Japan]
Zou P.,
Pinotsis N.,
Lange S.,
Song Y.-H.,
Popov A.,
Mavridis I.,
Mayans O.M.,
Gautel M.,
Wilmanns M.;
"Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk.";
Nature 439:229-233(2006).
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[34]
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VARIANT CMH9 LEU-740.
DOI=10.1006/bbrc.1999.1221; PubMed=10462489 [NCBI, ExPASy, EBI, Israel, Japan]
Satoh M.,
Takahashi M.,
Sakamoto T.,
Hiroe M.,
Marumo F.,
Kimura A.;
"Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease gene.";
Biochem. Biophys. Res. Commun. 262:411-417(1999).
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[35]
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INVOLVEMENT IN LIMB-GIRDLE MUSCULAR DYSTROPHY TYPE 2J, AND VARIANT TMD PRO-34315.
DOI=10.1086/342380; PubMed=12145747 [NCBI, ExPASy, EBI, Israel, Japan]
Hackman P.,
Vihola A.,
Haravuori H.,
Marchand S.,
Sarparanta J.,
De Seze J.,
Labeit S.,
Witt C.,
Peltonen L.,
Richard I.,
Udd B.;
"Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin.";
Am. J. Hum. Genet. 71:492-500(2002).
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[36]
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VARIANTS CMD1G MET-54; VAL-743; TYR-3799 AND ASN-4465, VARIANTS CYS-328; GLN-4084 AND PRO-4215, AND CHARACTERIZATION OF VARIANTS CMD1G MET-54 AND VAL-743.
DOI=10.1006/bbrc.2002.6448; PubMed=11846417 [NCBI, ExPASy, EBI, Israel, Japan]
Itoh-Satoh M.,
Hayashi T.,
Nishi H.,
Koga Y.,
Arimura T.,
Koyanagi T.,
Takahashi M.,
Hohda S.,
Ueda K.,
Nouchi T.,
Hiroe M.,
Marumo F.,
Imaizumi T.,
Yasunami M.,
Kimura A.;
"Titin mutations as the molecular basis for dilated cardiomyopathy.";
Biochem. Biophys. Res. Commun. 291:385-393(2002).
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[37]
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VARIANT CMD1G ARG-976.
DOI=10.1038/ng815; PubMed=11788824 [NCBI, ExPASy, EBI, Israel, Japan]
Gerull B.,
Gramlich M.,
Atherton J.,
McNabb M.,
Trombitas K.,
Sasse-Klaassen S.,
Seidman J.G.,
Seidman C.,
Granzier H.,
Labeit S.,
Frenneaux M.,
Thierfelder L.;
"Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy.";
Nat. Genet. 30:201-204(2002).
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[38]
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VARIANT TMD ASN-34306.
DOI=10.1002/ana.10647; PubMed=12891679 [NCBI, ExPASy, EBI, Israel, Japan]
Van den Bergh P.Y.K.,
Bouquiaux O.,
Verellen C.,
Marchand S.,
Richard I.,
Hackman P.,
Udd B.;
"Tibial muscular dystrophy in a Belgian family.";
Ann. Neurol. 54:248-251(2003).
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[39]
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VARIANT CMD1G GLN-32996.
DOI=10.1007/s10974-005-9018-5; PubMed=16465475 [NCBI, ExPASy, EBI, Israel, Japan]
Matsumoto Y.,
Hayashi T.,
Inagaki N.,
Takahashi M.,
Hiroi S.,
Nakamura T.,
Arimura T.,
Nakamura K.,
Ashizawa N.,
Yasunami M.,
Ohe T.,
Yano K.,
Kimura A.;
"Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy.";
J. Muscle Res. Cell Motil. 26:367-374(2005).
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[40]
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VARIANT HMERF TRP-279, CHARACTERIZATION OF VARIANT HMERF TRP-279, AND INTERACTION WITH NBR1.
DOI=10.1126/science.1110463; PubMed=15802564 [NCBI, ExPASy, EBI, Israel, Japan]
Lange S.,
Xiang F.,
Yakovenko A.,
Vihola A.,
Hackman P.,
Rostkova E.,
Kristensen J.,
Brandmeier B.,
Franzen G.,
Hedberg B.,
Gunnarsson L.G.,
Hughes S.M.,
Marchand S.,
Sejersen T.,
Richard I.,
Edstroem L.,
Ehler E.,
Udd B.,
Gautel M.;
"The kinase domain of titin controls muscle gene expression and protein turnover.";
Science 308:1599-1603(2005).
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[41]
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INVOLVEMENT IN EOMFC.
DOI=10.1002/ana.21089; PubMed=17444505 [NCBI, ExPASy, EBI, Israel, Japan]
Carmignac V.,
Salih M.A.M.,
Quijano-Roy S.,
Marchand S.,
Al Rayess M.M.,
Mukhtar M.M.,
Urtizberea J.A.,
Labeit S.,
Guicheney P.,
Leturcq F.,
Gautel M.,
Fardeau M.,
Campbell K.P.,
Richard I.,
Estournet B.,
Ferreiro A.;
"C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy.";
Ann. Neurol. 61:340-351(2007).
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[42]
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VARIANTS [LARGE SCALE ANALYSIS] TYR-60; MET-115; CYS-328; THR-360; ILE-498; MET-799; ILE-811; HIS-922; ASP-937; THR-1081; ARG-1137; GLU-1201; ALA-1202; SER-1295; ASP-1345; THR-1347; HIS-1350; LEU-1353; VAL-1393; CYS-1416; PRO-1441; VAL-1544; ARG-1572; GLY-1658; GLN-1664; ASP-1692; LEU-1744; GLY-1772; ILE-1907; HIS-1998; LEU-2107; THR-2118; THR-2164; TYR-2240; SER-2392; PHE-2432; MET-2610; MET-2771; PHE-2823; SER-2831; ILE-2930; ARG-3154; GLU-3191; LEU-3238; GLY-3250; MET-3261; GLN-3367; LYS-3482; PRO-3491; LYS-3570; VAL-3590; VAL-3762; PHE-3877; LEU-3965; PRO-4215; TRP-4238; PHE-4283; THR-4291; ASP-4303; GLU-4427; GLU-12310; HIS-12383; ALA-12469; CYS-12642; LYS-12657; GLU-12679; PHE-12720; CYS-12798; GLY-13049; LYS-13083; LEU-13096; ARG-13099; ALA-13297; MET-13399; THR-13418; VAL-13428; THR-13430; LYS-13434; ASN-13469; ASN-13495; SER-13785; HIS-13870; ILE-14109; GLN-14131; THR-14208; VAL-14728; THR-14999; THR-15021; VAL-15520; ILE-15555; GLN-15620; ILE-15629; CYS-15635; GLN-15700; PRO-15705; MET-15837; HIS-16058; ILE-16067; THR-16090; HIS-16195; CYS-16409; PRO-16424; MET-16629; ARG-16877; ASP-17060; VAL-17637; HIS-17838; ASN-17866; GLU-17906; ALA-18094; SER-18109; THR-18164; LEU-18221; THR-18222; GLN-18726; ALA-18835; LYS-18881; SER-18939; GLN-19000; GLN-19060; LYS-19091; SER-19224; ILE-19367; LYS-19392; SER-19480; GLY-19495; HIS-19665; ILE-19762; ARG-19947; MET-19956; GLN-19992; CYS-20057; LEU-20075; LYS-20179; THR-20198; VAL-20198; HIS-20331; THR-20408; LYS-20564; ILE-20718; PRO-20726; ASN-20892; ARG-20894; GLU-21125; SER-21403; CYS-21730; GLN-21747; ARG-21851; ARG-21851; ARG-21925; HIS-21995; VAL-22045; HIS-22149; ILE-22160; THR-22261; ASN-22306; HIS-22357; PRO-22408; HIS-22537; LEU-22584; PRO-22646; ALA-22670; ASP-22770; THR-22801; TRP-22823; GLN-22968; LEU-23074; PHE-23079; ASN-23282; TYR-23303; CYS-23306; SER-23515; GLN-23551; ASN-23807; ASN-23872; ALA-23891; HIS-23933; MET-23939; LEU-23952; GLY-24098; SER-24119; ILE-24133; ALA-24159; ALA-24239; LYS-24265; THR-24584; THR-24781; HIS-24799; HIS-24954; MET-24980; HIS-25659; THR-25679; ALA-25720; LYS-25821; LYS-25859; LYS-25879; VAL-25923; ILE-26045; GLU-26059; VAL-26134; CYS-26477; TYR-26843; ARG-27346; CYS-27652; VAL-27728; LEU-27754; THR-27755; VAL-27929; LEU-28132; GLN-28168; HIS-28538; THR-28572; THR-28948; VAL-28986; GLU-28993; VAL-28998; MET-29070; VAL-29090; CYS-29419; PRO-29479; LEU-29880; GLU-29976; GLY-30042; CYS-30107; PHE-30125; PRO-30211; THR-30412; SER-30617; ILE-30674; ILE-30809; ILE-30818; LYS-30825; THR-30856; ASP-30887; SER-30887; HIS-30897; HIS-30907; HIS-30946; PHE-31081; CYS-31107; GLY-31124; SER-31156; THR-31246; HIS-31330; ARG-31690; GLN-31724; ILE-31725; SER-31732; ILE-31886; CYS-32097; ASN-32171; ILE-32248; HIS-32281; HIS-32323; TRP-32411; VAL-32558; VAL-32610; VAL-32637; ALA-32922; ARG-32943; HIS-32953; LEU-33213; CYS-33242; MET-33387; ASP-33419; MET-33536; GLN-33568; LYS-33616; LEU-33620; VAL-33886; THR-33899; PRO-33904; ILE-33955 AND ALA-34115.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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