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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Brain;
DOI=10.1016/0014-5793(94)00395-5; PubMed=8194594 [NCBI, ExPASy, EBI, Israel, Japan]
Jakes R.,
Spillantini M.G.,
Goedert M.;
"Identification of two distinct synucleins from human brain.";
FEBS Lett. 345:27-32(1994).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1998.5556; PubMed=9806846 [NCBI, ExPASy, EBI, Israel, Japan]
Lavedan C.,
Leroy E.,
Torres R.,
Dehejia A.,
Dutra A.,
Buchholtz S.,
Nussbaum R.L.,
Polymeropoulos M.H.;
"Genomic organization and expression of the human beta-synuclein gene (SNCB).";
Genomics 54:173-175(1998).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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PHOSPHORYLATION.
DOI=10.1074/jbc.M003542200; PubMed=10852916 [NCBI, ExPASy, EBI, Israel, Japan]
Pronin A.N.,
Morris A.J.,
Surguchov A.,
Benovic J.L.;
"Synucleins are a novel class of substrates for G protein-coupled receptor kinases.";
J. Biol. Chem. 275:26515-26522(2000).
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- FUNCTION: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
- SUBCELLULAR LOCATION: Cytoplasm.
- TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
- PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
- DISEASE: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
- SIMILARITY: Belongs to the synuclein family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 134 AA [This is the length of the unprocessed precursor] |
Molecular weight: 14288 Da [This is the MW of the unprocessed precursor] |
CRC64: 5BCA9FCA615AC4EF [This is a checksum on the sequence] |
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10 20 30 40 50 60
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK
70 80 90 100 110 120
EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE
130
DPPQEEYQEY EPEA
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Q16143 in FASTA format |
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