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UniProtKB/Swiss-Prot entry Q9Y8G7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name C505_FUSOX
Primary accession number Q9Y8G7
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2002
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Bifunctional P-450:NADPH-P450 reductase
Synonyms Fatty acid omega-hydroxylase
P450foxy
Includes Cytochrome P450 505
     (EC 1.14.14.1)
NADPH--cytochrome P450 reductase
     (EC 1.6.2.4)
Gene name
Name: CYP505
From
Fusarium oxysporum [TaxID: 5507] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; mitosporic Hypocreales; Fusarium; Fusarium oxysporum species complex.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 82-99; 353-359; 362-380; 518-538; 616-626 AND 1005-1009, AND SUBCELLULAR LOCATION.
STRAIN=MT-811;
DOI=10.1074/jbc.M005617200; PubMed=10995755 [NCBI, ExPASy, EBI, Israel, Japan]
Kitazume T., Takaya N., Nakayama N., Shoun H.;
"Fusarium oxysporum fatty-acid subterminal hydroxylase (CYP505) is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3.";
J. Biol. Chem. 275:39734-39740(2000).
[2]
 FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=MT-811;
PubMed=8830036 [NCBI, ExPASy, EBI, Israel, Japan]
Nakayama N., Takemae A., Shoun H.;
"Cytochrome P450foxy, a catalytically self-sufficient fatty acid hydroxylase of the fungus Fusarium oxysporum.";
J. Biochem. 119:435-440(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB030037; BAA82526.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P14779; 1JPZ. [HSSP ENTRY / PDB]
ModBase Q9Y8G7.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0010181; Molecular function: FMN binding (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0003958; Molecular function: NADPH-hemoprotein reductase activity (inferred from electronic annotation from EC).
GO:0050381; Molecular function: unspecific monooxygenase activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
IPR003097; FAD-binding_1.
IPR001094; Flavdoxin_like.
IPR008254; Flavodoxin/NO_synth.
IPR001709; FPN_cyt_redctse.
IPR015702; NADPH_Cyt_Red.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19384:SF17; NADPH_Cyt_Red; 1.
Pfam PF00667; FAD_binding_1; 1.
PF00258; Flavodoxin_1; 1.
PF00175; NAD_binding_1; 1.
PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00369; FLAVODOXIN.
PR00371; FPNCR.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
PS51384; FAD_FR; 1.
PS50902; FLAVODOXIN_LIKE; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet Q9Y8G7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Electron transport; FAD; Flavoprotein; FMN; Heme; Iron; Membrane; Metal-binding; Monooxygenase; Multifunctional enzyme; NADP; Oxidoreductase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1066  1066     Bifunctional P-450:NADPH-P450 reductase. PRO_0000052210
DOMAIN   500    641  142     Flavodoxin-like. 
DOMAIN   676    904  229     FAD-binding FR-type. 
REGION   1    480  480     Cytochrome P450. 
REGION   481   1066  586     NADPH-P-450 reductase. 
METAL   407    407        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 1066 AA [This is the length of the unprocessed precursor] Molecular weight: 117926 Da [This is the MW of the unprocessed precursor] CRC64: 6B8123698C223DBA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAESVPIPEP PGYPLIGNLG EFTSNPLSDL NRLADTYGPI FRLRLGAKAP IFVSSNSLIN 

        70         80         90        100        110        120 
EVCDEKRFKK TLKSVLSQVR EGVHDGLFTA FEDEPNWGKA HRILVPAFGP LSIRGMFPEM 

       130        140        150        160        170        180 
HDIATQLCMK FARHGPRTPI DTSDNFTRLA LDTLALCAMD FRFYSYYKEE LHPFIEAMGD 

       190        200        210        220        230        240 
FLTESGNRNR RPPFAPNFLY RAANEKFYGD IALMKSVADE VVAARKASPS DRKDLLAAML 

       250        260        270        280        290        300 
NGVDPQTGEK LSDENITNQL ITFLIAGHET TSGTLSFAMY QLLKNPEAYS KVQKEVDEVV 

       310        320        330        340        350        360 
GRGPVLVEHL TKLPYISAVL RETLRLNSPI TAFGLEAIDD TFLGGKYLVK KGEIVTALLS 

       370        380        390        400        410        420 
RGHVDPVVYG NDADKFIPER MLDDEFARLN KEYPNCWKPF GNGKRACIGR PFAWQESLLA 

       430        440        450        460        470        480 
MVVLFQNFNF TMTDPNYALE IKQTLTIKPD HFYINATLRH GMTPTELEHV LAGNGATSSS 

       490        500        510        520        530        540 
THNIKAAANL DAKAGSGKPM AIFYGSNSGT CEALANRLAS DAPSHGFSAT TVGPLDQAKQ 

       550        560        570        580        590        600 
NLPEDRPVVI VTASYEGQPP SNAAHFIKWM EDLDGNDMEK VSYAVFACGH HDWVETFHRI 

       610        620        630        640        650        660 
PKLVDSTLEK RGGTRLVPMG SADAATSDMF SDFEAWEDIV LWPGLKEKYK ISDEESGGQK 

       670        680        690        700        710        720 
GLLVEVSTPR KTSLRQDVEE ALVVAEKTLT KSGPAKKHIE IQLPSAMTYK AGDYLAILPL 

       730        740        750        760        770        780 
NPKSTVARVF RRFSLAWDSF LKIQSEGPTT LPTNVAISAF DVFSAYVELS QPATKRNILA 

       790        800        810        820        830        840 
LAEATEDKDT IQELERLAGD AYQAEISPKR VSVLDLLEKF PAVALPISSY LAMLPPMRVR 

       850        860        870        880        890        900 
QYSISSSPFA DPSKLTLTYS LLDAPSLSGQ GRHVGVATNF LSHLTAGDKL HVSVRASSEA 

       910        920        930        940        950        960 
FHLPSDAEKT PIICVAAGTG LAPLRGFIQE RAAMLAAGRT LAPALLFFGC RNPEIDDLYA 

       970        980        990       1000       1010       1020 
EEFERWEKMG AVDVRRAYSR ATDKSEGCKY VQDRVYHDRA DVFKVWDQGA KVFICGSREI 

      1030       1040       1050       1060 
GKAVEDVCVR LAIEKAQQNG RDVTEEMARA WFERSRNERF ATDVFD
Q9Y8G7 in FASTA format

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