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UniProtKB/Swiss-Prot entry Q9XTI0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name 3HIDH_CAEEL
Primary accession number Q9XTI0
Secondary accession numbers None
Integrated into Swiss-Prot on January 24, 2001
Sequence was last modified on November 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial
Synonyms HIBADH
EC 1.1.1.31
Gene name
ORFNames: B0250.5
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z81453; CAB03798.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031630; CAB03798.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031630; CAA21003.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z81453; CAA21003.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T18682; T18682.
RefSeq NP_507943.1; -.
UniGene Cel.9442
3D structure databases
ModBase Q9XTI0.
Organism-specific databases
WormBase WBGene00007122; B0250.5.
WormPep B0250.5; CE18481. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q9XTI0; -.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0008442; Molecular function: 3-hydroxyisobutyrate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0004616; Molecular function: phosphogluconate dehydrogenase (decarboxylating) activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006098; Biological process: pentose-phosphate shunt (inferred from electronic annotation from InterPro).
GO:0006573; Biological process: valine metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002204; 3-OH-isobutyrate_DHase-rel_CS.
IPR015815; 3hydroxyacid_DHase/Rdtase.
IPR006115; 6PGDH_NAD-bd.
IPR013328; DHase_multihelical.
IPR011548; IsoBut3OH_DH.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
PANTHER PTHR22981; 3hydroxy_acid_DH; 1.
Pfam PF03446; NAD_binding_2; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01692; HIBADH; 1.
PROSITE PS00895; 3_HYDROXYISOBUT_DH; 1.
Genome annotation databases
Ensembl B0250.5; Caenorhabditis elegans. [Contig view]
GeneID 180344; -.
KEGG cel:B0250.5; -.
NMPDR fig|6239.3.peg.22089; -.
Other
NextBio 908956; -.
ProtoNet Q9XTI0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   299  299     Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial. PRO_0000173055
NP_BIND   2    30  29     NAD (Potential). 
ACT_SITE   172   172        Probable. 
Sequence information
Length: 299 AA [This is the length of the unprocessed precursor] Molecular weight: 31217 Da [This is the MW of the unprocessed precursor] CRC64: F30B423A597CABF0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLTGFIGLG NMGGHMARNL IKNGKKLIVY DVNKAVVQEF KAEGCEVAAH PADIAAASKE 

        70         80         90        100        110        120 
IITVLPSSPH VKAVYQGEAG IFKTIQPGTL CMDSSTIDQI VSLEVAQAAA LLKAEYIDAP 

       130        140        150        160        170        180 
ISGGVTGAQQ ATLTFMVGAG NDATFKRAEA VLSLMGKNIV NLGAVGNGTA AKICNNMLLG 

       190        200        210        220        230        240 
IQMVAVAETM NLGISMGLDA KALAGIVNTS SGRCWSSDTY NPVPGVIENI PSCRGYAGGF 

       250        260        270        280        290 
GTTLMAKDLS LAQNASTNTQ APTPMGSLAH QIYRILARDP QYQAKDFGVV YQFLKKQNS
Q9XTI0 in FASTA format

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