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UniProtKB/Swiss-Prot entry Q9UYU5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CDR_PYRAB
Primary accession number Q9UYU5
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on May 1, 2000 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 42)
Name and origin of the protein
Protein name Coenzyme A disulfide reductase
Synonyms CoA-disulfide reductase
CoADR
EC 1.8.1.14
Gene name
OrderedLocusNames: PYRAB14120
ORFNames: PAB0936
From
Pyrococcus abyssi [TaxID: 29292] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GE5 / Orsay;
DOI=10.1046/j.1365-2958.2003.03381.x; PubMed=12622808 [NCBI, ExPASy, EBI, Israel, Japan]
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O., Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
"An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi.";
Mol. Microbiol. 47:1495-1512(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ248287; CAB50317.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR H75052; H75052.
RefSeq NP_127087.1; -.
3D structure databases
HSSP P37062; 1NHP. [HSSP ENTRY / PDB]
ModBase Q9UYU5.
Enzyme and pathway databases
BioCyc PABY272844:PAB0936-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0050451; Molecular function: CoA-disulfide reductase activity (inferred from electronic annotation from EC).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000759; Adrndx_reductase.
IPR017758; CoA_disulphide_reductase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 2.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
Genome annotation databases
GeneID 1496802; -.
GenomeReviews AL096836_GR; PYRAB14120.
KEGG pab:PAB0936; -.
NMPDR fig|272844.1.peg.1495; -.
Phylogenomic databases
HOGENOM Q9UYU5; -.
Genome annotation databases
CMR Q9UYU5; PYRAB14120.
Other
ProtoNet Q9UYU5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   446  446     Coenzyme A disulfide reductase. PRO_0000184697
NP_BIND   14    39  26     FAD (By similarity). 
NP_BIND   155   170  16     NADP (By similarity). 
NP_BIND   274   284  11     FAD (By similarity). 
ACT_SITE   49    49        Nucleophile (By similarity). 
ACT_SITE   49    49        Redox-active (By similarity). 
BINDING   21    21        Substrate. 
BINDING   25    25        Substrate. 
BINDING   28    28        Substrate (By similarity). 
BINDING   45    45        Substrate (By similarity). 
BINDING   76    76        Substrate. 
BINDING   426   426        FAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 446 AA [This is the length of the unprocessed precursor] Molecular weight: 49181 Da [This is the MW of the unprocessed precursor] CRC64: 0B7048662F50BD72 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRVVKVKKTV VIIGGGAAGM SAASRVKRLK PEWDVKVFEA TEWVSHAPCG IPYVVEGISP 

        70         80         90        100        110        120 
TEKLMHYPPE VFIKKRGIDL HLNAEVIEVD TGYVRVREKD GEKSYEWDYL VFANGASPQV 

       130        140        150        160        170        180 
PAIEGVDLKG VFTADLPPDA VAIREYMEKN RVEDVVIVGG GYIGLEMAEA FVAQGKRVTM 

       190        200        210        220        230        240 
IVRGERILRR SFDKEVTDII EEKLKQHVNL RLQEIVLRIE GKDRVEKVVT DAGEYRADLV 

       250        260        270        280        290        300 
ILATGIKPNI ELARQLGVRI GETGAIWTNE KMQTSVENVY AAGDVAETKH VITGRRVWVP 

       310        320        330        340        350        360 
LAPPGNKMGY VAGSNIAGKE IHFPGVLGTT VTKFLDVEIG KTGLTETEAL KEGYDIRTAF 

       370        380        390        400        410        420 
IKASTRPHYY PGGKEIWLKG VVDNETNRLL GVQAVGAEIL PRIDAAAAML MANFTTKDAF 

       430        440 
FTDLAYAPPF APVWDPLVVL ARVLKF
Q9UYU5 in FASTA format

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