[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Burger G.; "The mitochondrial genome of Cafeteria roenbergensis."; Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF193903; AAF05789.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_051138.1; -.

3D structure databases

ModBase

Q9TAJ7.

Ontologies

GO:0005746;	Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0051287;	Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

Genome annotation databases

GeneID

800841; -.

Other

ProtoNet

Q9TAJ7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 398`	`398`		`NADH-ubiquinone oxidoreductase 49 kDa subunit.`	`PRO_0000118588`

Sequence information

Length: 398 AA [This is the length of the unprocessed precursor]

Molecular weight: 45813 Da [This is the MW of the unprocessed precursor]

CRC64: 1BDDAF669C91404E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFIKRKLKET EIKDFTLNFG PQHPAAHGVL RLILELNGET IKNADPHIGL LHRGTEKLIE 

        70         80         90        100        110        120 
NRNYLQALPY FDRLDYVSMM VQEHAYSLAV ERLYGINIPQ RAQWIRVLFS EITRILNHLL 

       130        140        150        160        170        180 
AIGCHSMDVG AMTPLLWGFE EREKLMEFYE RVSGARMHAS YIRPGGVAQD LPSGFVEDVY 

       190        200        210        220        230        240 
SFILDFSVRL DEIEELLTNN RIWKQRLVNV GIVTAKQAIQ NGFSGVLLRS TGIPWDLRRS 

       250        260        270        280        290        300 
QPYEIYDKVP FRIPVGTRGD CYDRYLIRMQ EMRQSLRIMM ACLKYLPGGS IKSDDKKFVP 

       310        320        330        340        350        360 
PLRWEMKNSM ESVIHHFKYF TEGFKVPAGQ TYAAVEAPKG EMGVFLISDG SNQPFRCKIK 

       370        380        390 
APGFFHLQNL PEMTKHHMIA DVVTIIGTQD IVFGEVDR

Q9TAJ7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools