NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, AND INTERACTION WITH GRIA2.
STRAIN=Sprague-Dawley;
TISSUE=Cerebellum;
DOI=10.1006/bbrc.1999.1723; PubMed=10558890 [NCBI, ExPASy, EBI, Israel, Japan]
Inagaki H., Maeda S., Lin K.H., Shimizu N., Saito T.;
"rDLG6: a novel homolog of Drosophila DLG expressed in rat brain.";
Biochem. Biophys. Res. Commun. 265:462-468(1999).

Comments

FUNCTION: May play a role in retinal photoreceptors development (By similarity).
SUBUNIT: Interacts with MPDZ (By similarity). May interact with GRIA2. Forms a complex with CRB1 and MPP5 (By similarity).
INTERACTION:
Q6P7B6:Efnb1; NbExp=1; IntAct=EBI-937554, EBI-937609;
P19491:Gria2; NbExp=1; IntAct=EBI-937554, EBI-77718;
P35407:Il8rb; NbExp=1; IntAct=EBI-937554, EBI-937591;
SUBCELLULAR LOCATION: Cytoplasm. Note=Localized at photoreceptor synaptic terminals in retina (By similarity).

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	Alpha
Isoform ID	Q9QYH1-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	Beta
Isoform ID	Q9QYH1-2
Features which should be applied to build the isoform sequence: VSP_014001.

Name	3
Synonyms	Gamma
Isoform ID	Q9QYH1-3
Features which should be applied to build the isoform sequence: VSP_014000.

TISSUE SPECIFICITY: Highly expressed in brain and detected in lung, and bone (at protein level). Also expressed in intestine and spleen.
SIMILARITY: Belongs to the MAGUK family.
SIMILARITY: Contains 1 guanylate kinase-like domain.
SIMILARITY: Contains 1 PDZ (DHR) domain.
SIMILARITY: Contains 1 SH3 domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB030499; BAA88229.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB030500; BAA88230.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB030501; BAA88231.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_067088.2; -.

UniGene

Rn.163075

3D structure databases

HSSP

Q64010; 1M3B. [HSSP ENTRY / PDB]

ModBase

Q9QYH1.

Protein-protein interaction databases

IntAct

Q9QYH1; -.

Organism-specific databases

RGD

620016; Mpp4.

Gene expression databases

ArrayExpress

Q9QYH1; -.

GermOnline

ENSRNOG00000010486; Rattus norvegicus.

Ontologies

GO:0005102;	Molecular function: receptor binding (inferred from physical interaction from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR008144; Guanylate_kin.
IPR008145; Guanylt/Ca.
IPR001478; PDZ.
IPR001452; SH3.
IPR011511; SH3_2.
Graphical view of domain structure.

Pfam

PF00625; Guanylate_kin; 1.
PF00595; PDZ; 1.
PF07653; SH3_2; 1.
Pfam graphical view of domain structure.

PRINTS

PR00452; SH3DOMAIN.

ProDom

PD000066; SH3; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00072; GuKc; 1.
SM00228; PDZ; 1.
SM00326; SH3; 1.
SMART graphical view of domain structure.

PROSITE

PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS50106; PDZ; 1.
PS50002; SH3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q9QYH1.

Genome annotation databases

Ensembl

ENSRNOG00000010486; Rattus norvegicus. [Contig view]

GeneID

58808; -.

KEGG

rno:58808; -.

Phylogenomic databases

HOVERGEN

Q9QYH1; -.

Other

ProtoNet

Q9QYH1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Coiled coil; Cytoplasm; SH3 domain.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 441`	`441`	`MAGUK p55 subfamily member 4.`	`PRO_0000094579`
`DOMAIN`	`1 84`	`84`	`PDZ.`
`DOMAIN`	`91 161`	`71`	`SH3.`
`DOMAIN`	`232 421`	`190`	`Guanylate kinase-like.`
`COILED`	`373 430`	`58`	`Potential.`
`VAR_SEQ`	`181 441`		`Missing (in isoform 3).`	`VSP_014000`
`VAR_SEQ`	`334 351`		`Missing (in isoform 2).`	`VSP_014001`

Sequence information

Length: 441 AA [This is the length of the unprocessed precursor]

Molecular weight: 50052 Da [This is the MW of the unprocessed precursor]

CRC64: EB5F0711B4AC7CD6 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL 

        70         80         90        100        110        120 
DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL 

       130        140        150        160        170        180 
KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR 

       190        200        210        220        230        240 
SKEEFVGDGQ QFFIAGFRQQ HANMRCTCSC YSAVGAPYEE VVRYQRQPAD KHRLIVLVGP 

       250        260        270        280        290        300 
SGVGVNELRR QLIGCNPSCF QSAVPHTTRS PKSYEMDGRE YHYVSRETFE SLMYGHRMLE 

       310        320        330        340        350        360 
FGEYKGHLYG TSVNAVLAVL DEGKICVMDL EPQDIQLART RELKPYVIFI KPPSMSSMRH 

       370        380        390        400        410        420 
SRRNAKIITD YFVDMKFKDE DLQEMEELAQ KMESQFGQFF DHVIVNDNLQ DARAQLLSAI 

       430        440 
QKAEEELQWV PEAWVSPGAE S

Q9QYH1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools