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UniProtKB/Swiss-Prot entry Q9NR16


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name C163B_HUMAN
Primary accession number Q9NR16
Secondary accession number Q6UWC2
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on October 1, 2000 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 57)
Name and origin of the protein
Protein name Scavenger receptor cysteine-rich type 1 protein M160 [Precursor]
Synonyms CD163 antigen-like 1
CD163b antigen
Gene name
Name: CD163L1
Synonyms: CD163B, M160
ORFNames: UNQ6434/PRO23202
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
PubMed=11086079 [NCBI, ExPASy, EBI, Israel, Japan]
Groenlund J., Vitved L., Lausen M., Skjoedt K., Holmskov U.;
"Cloning of a novel scavenger receptor cysteine-rich type I transmembrane molecule (M160) expressed by human macrophages.";
J. Immunol. 165:6406-6415(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
PROTEIN SEQUENCE OF 41-55.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[4]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1161, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1021/pr8008012; PubMed=19159218 [NCBI, ExPASy, EBI, Israel, Japan]
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF264014; AAF91396.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358856; AAQ89215.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00026975; -.
IPI00657946; -.
IPI00658056; -.
RefSeq NP_777601.2; -.
UniGene Hs.631727
3D structure databases
HSSP Q08380; 1BY2. [HSSP ENTRY / PDB]
ModBase Q9NR16.
PTM databases
PhosphoSite Q9NR16; -.
Organism-specific databases
GeneCards GC12M007399; -.
H-InvDB HIX0018278; -.
HGNC HGNC:30375; CD163L1.
GenAtlas CD163L1.
HPA HPA015663; -.
MIM 606079; gene. [NCBI / EBI]
PharmGKB PA142672145; -.
Gene expression databases
ArrayExpress Q9NR16; -.
Bgee Q9NR16; -.
CleanEx HS_CD163L1; -.
GermOnline ENSG00000177675; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005044; Molecular function: scavenger receptor activity (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001190; Srcr_rcpt.
IPR017448; Srcr_rcpt-rel.
Graphical view of domain structure.
Pfam PF00530; SRCR; 12.
Pfam graphical view of domain structure.
SMART SM00202; SR; 12.
SMART graphical view of domain structure.
PROSITE PS00420; SRCR_1; 5.
PS50287; SRCR_2; 12.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q9NR16; -.
Genome annotation databases
Ensembl ENSG00000177675; Homo sapiens. [Contig view]
GeneID 283316; -.
KEGG hsa:283316; -.
Phylogenomic databases
HOGENOM Q9NR16; -.
HOVERGEN Q9NR16; -.
Other
NextBio 93813; -.
SOURCE CD163L1; Homo sapiens.
ProtoNet Q9NR16.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Repeat; Secreted; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     40  40      
CHAIN   41   1453  1413     Scavenger receptor cysteine-rich type 1 protein M160. PRO_0000045392
TOPO_DOM   41   1359  1319     Extracellular (Potential). 
TRANSMEM   1360   1380  21     Potential. 
TOPO_DOM   1381   1453  73     Cytoplasmic (Potential). 
DOMAIN   48    148  101     SRCR 1. 
DOMAIN   155    255  101     SRCR 2. 
DOMAIN   262    362  101     SRCR 3. 
DOMAIN   369    469  101     SRCR 4. 
DOMAIN   476    576  101     SRCR 5. 
DOMAIN   583    683  101     SRCR 6. 
DOMAIN   690    790  101     SRCR 7. 
DOMAIN   795    895  101     SRCR 8. 
DOMAIN   900   1000  101     SRCR 9. 
DOMAIN   1036   1136  101     SRCR 10. 
DOMAIN   1141   1243  103     SRCR 11. 
DOMAIN   1246   1346  101     SRCR 12. 
CARBOHYD   42     42        N-linked (GlcNAc...) (Potential). 
CARBOHYD   78     78        N-linked (GlcNAc...) (Potential). 
CARBOHYD   120    120        N-linked (GlcNAc...) (Potential). 
CARBOHYD   161    161        N-linked (GlcNAc...) (Potential). 
CARBOHYD   334    334        N-linked (GlcNAc...) (Potential). 
CARBOHYD   377    377        N-linked (GlcNAc...) (Potential). 
CARBOHYD   441    441        N-linked (GlcNAc...) (Potential). 
CARBOHYD   548    548        N-linked (GlcNAc...) (Potential). 
CARBOHYD   637    637        N-linked (GlcNAc...) (Potential). 
CARBOHYD   972    972        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1013   1013        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1084   1084        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1104   1104        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1161   1161        N-linked (GlcNAc...). 
CARBOHYD   1171   1171        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1318   1318        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1354   1354        N-linked (GlcNAc...) (Potential). 
DISULFID   73    137        By similarity. 
DISULFID   86    147        By similarity. 
DISULFID   117    127        By similarity. 
DISULFID   180    244        By similarity. 
DISULFID   193    254        By similarity. 
DISULFID   224    234        By similarity. 
DISULFID   287    351        By similarity. 
DISULFID   300    361        By similarity. 
DISULFID   331    341        By similarity. 
DISULFID   394    458        By similarity. 
DISULFID   407    468        By similarity. 
DISULFID   438    448        By similarity. 
DISULFID   501    565        By similarity. 
DISULFID   514    575        By similarity. 
DISULFID   545    555        By similarity. 
DISULFID   608    672        By similarity. 
DISULFID   621    682        By similarity. 
DISULFID   652    662        By similarity. 
DISULFID   715    779        By similarity. 
DISULFID   728    789        By similarity. 
DISULFID   759    769        By similarity. 
DISULFID   820    884        By similarity. 
DISULFID   833    894        By similarity. 
DISULFID   864    874        By similarity. 
DISULFID   925    989        By similarity. 
DISULFID   938    999        By similarity. 
DISULFID   969    979        By similarity. 
DISULFID   1061   1125        By similarity. 
DISULFID   1074   1135        By similarity. 
DISULFID   1105   1115        By similarity. 
DISULFID   1181   1242        By similarity. 
DISULFID   1212   1222        By similarity. 
DISULFID   1271   1335        By similarity. 
DISULFID   1284   1345        By similarity. 
DISULFID   1315   1325        By similarity. 
VAR_SEQ   718    727        GWGMNIAEVV -> SFLMTSSKPR (in isoform 3). VSP_016875
VAR_SEQ   728   1453        Missing (in isoform 3). VSP_016876
VAR_SEQ   1395   1426        Missing (in isoform 2). VSP_016877
VARIANT   578    578  1     D -> N (in dbSNP:rs4072797 [NCBI]). VAR_057206 
VARIANT   582    582  1     G -> A (in dbSNP:rs4072796 [NCBI]). VAR_057207 
VARIANT   1055   1055  1     G -> S (in dbSNP:rs36206713 [NCBI]). VAR_057208 
VARIANT   1108   1108  1     M -> T (in dbSNP:rs35480970 [NCBI]). VAR_057209 
Sequence information
Length: 1453 AA [This is the length of the unprocessed precursor] Molecular weight: 159264 Da [This is the MW of the unprocessed precursor] CRC64: 15445CE9868CF58A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT 

        70         80         90        100        110        120 
VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN 

       130        140        150        160        170        180 
ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC 

       190        200        210        220        230        240 
DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG 

       250        260        270        280        290        300 
NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC 

       310        320        330        340        350        360 
KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI 

       370        380        390        400        410        420 
CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR 

       430        440        450        460        470        480 
RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG 

       490        500        510        520        530        540 
AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPMHVFGMTY FKEASGPIWL 

       550        560        570        580        590        600 
DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF 

       610        620        630        640        650        660 
QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW 

       670        680        690        700        710        720 
SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG 

       730        740        750        760        770        780 
MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH 

       790        800        810        820        830        840 
LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD 

       850        860        870        880        890        900 
AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV 

       910        920        930        940        950        960 
RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV 

       970        980        990       1000       1010       1020 
RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS 

      1030       1040       1050       1060       1070       1080 
AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG 

      1090       1100       1110       1120       1130       1140 
VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA 

      1150       1160       1170       1180       1190       1200 
LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT 

      1210       1220       1230       1240       1250       1260 
GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSTAEETWI TCEDRIRVRG GDTECSGRVE 

      1270       1280       1290       1300       1310       1320 
IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES 

      1330       1340       1350       1360       1370       1380 
FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGRL ALILSSIFGL LLPVLFILFL 

      1390       1400       1410       1420       1430       1440 
TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT 

      1450 
SLLGVLPASE ATK 

Q9NR16 in FASTA format

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