ID   HPPD_PSEAE              Reviewed;         357 AA.
AC   Q9I576;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   22-JUL-2008, entry version 40.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
DE            EC=1.13.11.27;
GN   Name=hpd; OrderedLocusNames=PA0865;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX   MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; AE004091; AAG04254.1; -; Genomic_DNA.
DR   PIR; F83537; F83537.
DR   RefSeq; NP_249556.1; -.
DR   HSSP; P80064; 1CJX.
DR   GeneID; 882225; -.
DR   GenomeReviews; AE004091_GR; PA0865.
DR   KEGG; pae:PA0865; -.
DR   PseudoCAP; PA0865; -.
DR   HOGENOM; Q9I576; -.
DR   BioCyc; PAER208964:PA0865-MON; -.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    357       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000287741.
FT   METAL       168    168       Iron (By similarity).
FT   METAL       246    246       Iron (By similarity).
FT   METAL       325    325       Iron (By similarity).
SQ   SEQUENCE   357 AA;  39913 MW;  016A5C233DE0E2F9 CRC64;
     MNAVAKIEQH NPIGTDGFEF VEFTAPDAKG IEQLRQLFNM MGFTETAKHR SKEVFLFQQN
     DINIVLNGSP TGHVHEFALK HGPSACAMAF RVKNASQAAA YAESQGAKLV GSHANFGELN
     IPSLEGIGGS LLYLVDRYGD RSIYDVDFEF IEGRSANDNS VGLTYIDHLT HNVKRGQMDV
     WSGFYERIAN FREIRYFDIE GKLTGLFSRA MTAPCGKIRI PINESADDTS QIEEFIREYH
     GEGIQHIALT TDDIYATVRK LRDNGVKFMS TPDTYYEKVD TRVAGHGEPL EQLRELNLLI
     DGAPGDDGIL LQIFTDTVIG PIFFEIIQRK GNQGFGEGNF KALFESIEED QIRRGVI
//