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UniProtKB/Swiss-Prot entry Q9HCT0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FGF22_HUMAN
Primary accession number Q9HCT0
Secondary accession numbers None
Integrated into Swiss-Prot on April 27, 2001
Sequence was last modified on March 1, 2001 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 64)
Name and origin of the protein
Protein name Fibroblast growth factor 22 [Precursor]
Synonym FGF-22
Gene name
Name: FGF22
ORFNames: UNQ2500/PRO5800
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
DOI=10.1016/S0167-4781(00)00302-X; PubMed=11342227 [NCBI, ExPASy, EBI, Israel, Japan]
Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.;
"Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle.";
Biochim. Biophys. Acta 1517:460-463(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NIEHS SNPs program;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[4]
INTERACTION WITH FGFBP1.
DOI=10.1038/sj.onc.1208560; PubMed=15806171 [NCBI, ExPASy, EBI, Israel, Japan]
Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A., Werner S.;
"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.";
Oncogene 24:5269-5277(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB021925; BAB13479.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY359084; AAQ89955.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY426986; AAQ93357.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_065688.1; -.
UniGene Hs.248087
3D structure databases
HSSP O15520; 1NUN. [HSSP ENTRY / PDB]
ModBase Q9HCT0.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Organism-specific databases
GeneCards GC19P000590; -.
H-InvDB HIX0039926; -.
HGNC HGNC:3679; FGF22.
GenAtlas FGF22.
MIM 605831; gene. [NCBI / EBI]
PharmGKB PA28118; -.
GeneCards Q9HCT0.
Gene expression databases
CleanEx HS_FGF22; -.
GermOnline ENSG00000070388; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (non-traceable author statement from UniProtKB).
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from InterPro).
GO:0030154; Biological process: cell differentiation (non-traceable author statement from UniProtKB).
GO:0008543; Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; FALSE_NEG.
Proteomics databases
PRIDE Q9HCT0; -.
Genome annotation databases
Ensembl ENSG00000070388; Homo sapiens. [Contig view]
GeneID 27006; -.
KEGG hsa:27006; -.
Phylogenomic databases
HOGENOM Q9HCT0; -.
HOVERGEN Q9HCT0; -.
Other
NextBio 49512; -.
SOURCE FGF22; Homo sapiens.
ProtoNet Q9HCT0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   170  148     Fibroblast growth factor 22. PRO_0000008996
Sequence information
Length: 170 AA [This is the length of the unprocessed precursor] Molecular weight: 19663 Da [This is the MW of the unprocessed precursor] CRC64: CB88918C2D5A4CE7 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR 

        70         80         90        100        110        120 
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE 

       130        140        150        160        170 
ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS 

Q9HCT0 in FASTA format

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