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UniProtKB/Swiss-Prot entry Q9EPL9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACOX3_MOUSE
Primary accession number Q9EPL9
Secondary accession numbers Q7TPP6 Q80UQ0
Integrated into Swiss-Prot on November 2, 2001
Sequence was last modified on February 20, 2007 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 54)
Name and origin of the protein
Protein name Peroxisomal acyl-coenzyme A oxidase 3
Synonyms EC 1.3.3.6
Pristanoyl-CoA oxidase
Branched-chain acyl-CoA oxidase
BRCACox
Gene name
Name: Acox3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Van Veldhoven P.P., Ghys K.;
"Cloning of the mouse pristanoyl-CoA oxidase.";
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N, and FVB/N-3;
TISSUE=Liver, and Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ278430; CAC20692.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC044725; AAH44725.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC055019; AAH55019.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_109646.2; -.
UniGene Mm.291503
3D structure databases
HSSP P07872; 1IS2. [HSSP ENTRY / PDB]
ModBase Q9EPL9.
PTM databases
PhosphoSite Q9EPL9; -.
Organism-specific databases
MGI MGI:1933156; Acox3.
Gene expression databases
ArrayExpress Q9EPL9; -.
CleanEx MM_ACOX3; -.
GermOnline ENSMUSG00000029098; Mus musculus.
Ontologies
GO
GO:0005782; Cellular component: peroxisomal matrix (traceable author statement from MGI).
GO:0003995; Molecular function: acyl-CoA dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0050660; Molecular function: FAD binding (inferred from electronic annotation from InterPro).
GO:0016402; Molecular function: pristanoyl-CoA oxidase activity (traceable author statement from MGI).
GO:0006635; Biological process: fatty acid beta-oxidation (traceable author statement from MGI).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR012258; Acyl-CoA_oxidase.
IPR002655; Acyl_CoA_ox_C.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 2.
PANTHER PTHR10909:SF11; Acyl-CoA_oxidase; 1.
Pfam PF01756; ACOX; 1.
PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000168; Acyl-CoA_oxidase; 1.
Genome annotation databases
Ensembl ENSMUSG00000029098; Mus musculus. [Contig view]
GeneID 80911; -.
KEGG mmu:80911; -.
Phylogenomic databases
HOGENOM Q9EPL9; -.
HOVERGEN Q9EPL9; -.
Other
NextBio 350282; -.
SOURCE Acox3; Mus musculus.
ProtoNet Q9EPL9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase; Peroxisome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   700  700     Peroxisomal acyl-coenzyme A oxidase 3. PRO_0000204686
MOTIF   698   700  3     Microbody targeting signal (By similarity). 
CONFLICT   177   178        DP -> ES (in Ref. 1; CAC20692). 
CONFLICT   364   364        Y -> H (in Ref. 1; CAC20692). 
CONFLICT   408   409        KP -> NR (in Ref. 1; CAC20692). 
CONFLICT   555   555        C -> V (in Ref. 1; CAC20692). 
CONFLICT   576   576        H -> Y (in Ref. 2; AAH44725). 
CONFLICT   593   594        TL -> SV (in Ref. 1; CAC20692). 
CONFLICT   607   607        L -> S (in Ref. 1; CAC20692). 
CONFLICT   669   669        A -> R (in Ref. 1; CAC20692). 
CONFLICT   681   681        A -> R (in Ref. 1; CAC20692). 
Sequence information
Length: 700 AA [This is the length of the unprocessed precursor] Molecular weight: 78404 Da [This is the MW of the unprocessed precursor] CRC64: 85C448E38A4A0C67 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGSLPEEKDS ALWSDTPKGP LSAYRARASF NSGELLLFWD GQDVIHFKKT IFSTLENDPL 

        70         80         90        100        110        120 
FARSYGADLP LEKLRELNFL RCKRVFEYGF FKVEELLKNP LKILVLINCL GMYDWSLANK 

       130        140        150        160        170        180 
CVLHMLVFGT TVFVSGSEKH FKYLEKIYSL EIFGCFALTE LSHGSNTKAM RTTAHYDPDT 

       190        200        210        220        230        240 
QEFILHSPDF EAAKFWVGNL GKTATHAVVF AQLYMPDGQC HGLHSFLVQI RDTKTLLPMT 

       250        260        270        280        290        300 
GVMVGDIGKK LGQNGLDNGF AMFNKVRIPR QNLLDRTGNI TSEGTYNSPF KDVRQRLGAS 

       310        320        330        340        350        360 
LGSLSSGRIS IISMSVVNLK LAVSIAIRFS ATRCQFGPTD KEEIPVLEYP LQQWRILPYL 

       370        380        390        400        410        420 
AAAYALDHFS KTIFMDLIEV QSARLRGDHS DQQAELGREI HALASAGKPL ASWTAQRGIQ 

       430        440        450        460        470        480 
ECREACGGHG YLAMNRFGDL RNDNDPNCTY EGDNNVLLQQ TSNYLLSLLE PPLQDGAHFT 

       490        500        510        520        530        540 
SPLKTVDFLE AYPGILGQKF LGSSKADWMD SAAPLAAYRW LVCYLLQESH RRYCQEKKSR 

       550        560        570        580        590        600 
GSDFEARNNS QVYGCRPLAL AFMELTVMQR FHEHIHSSGL SPSLRTVLGR LSTLYGLWCL 

       610        620        630        640        650        660 
SQHMALLYRG GYISGEQTGR AMEDAILTLC EQLKDDAVAL VDVIAPSDFV LNSPIAKADG 

       670        680        690        700 
ELYKNLWAAV LQQNGVLERA AWWPEFSANK SVADRLKSQL
Q9EPL9 in FASTA format

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