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UniProtKB/Swiss-Prot entry Q9BRP4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PAAF1_HUMAN
Primary accession number Q9BRP4
Secondary accession numbers A6NDR5 Q4G165 Q53HS9 Q7Z500 Q8TBU6 Q9HAB6
Integrated into Swiss-Prot on May 16, 2006
Sequence was last modified on May 16, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 52)
Name and origin of the protein
Protein name Proteasomal ATPase-associated factor 1
Synonyms WD repeat-containing protein 71
Protein G-16
Gene name
Name: PAAF1
Synonyms: WDR71
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLY-209.
Bi A.D., Yu L., Tu Q., Yang J., Dai F.Y., Cui W.C., Zheng L.H., Zhao S.Y.;
"Cloning of a new human cDNA homology to Xenopus laevis gene 16 mRNA.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Embryo;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-139.
TISSUE=Adipose tissue;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04632; PubMed=16554811 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene identification.";
Nature 440:497-500(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS VAL-53 AND GLY-209.
TISSUE=Brain, and Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH PSMC1; PSMC2; PSMC3; PSMC4; PSMC5 AND PSMC6, AND MASS SPECTROMETRY.
DOI=10.1128/MCB.25.9.3842-3853.2005; PubMed=15831487 [NCBI, ExPASy, EBI, Israel, Japan]
Park Y., Hwang Y.-P., Lee J.-S., Seo S.-H., Yoon S.K., Yoon J.-B.;
"Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.";
Mol. Cell. Biol. 25:3842-3853(2005).
[8]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/bi061994u; PubMed=17323924 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.;
"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.";
Biochemistry 46:3553-3565(2007).
[9]
FUNCTION, AND INTERACTION WITH HIV-1 TAT.
DOI=10.1016/j.molcel.2006.12.020; PubMed=17289585 [NCBI, ExPASy, EBI, Israel, Japan]
Lassot I., Latreille D., Rousset E., Sourisseau M., Linares L.K., Chable-Bessia C., Coux O., Benkirane M., Kiernan R.E.;
"The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms.";
Mol. Cell 25:369-383(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF087895; AAP97194.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK021910; BAB13933.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK222501; BAD96221.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP002770; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471076; EAW74917.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC006142; AAH06142.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC021541; AAH21541.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028628; AAH28628.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_079431.1; -.
UniGene Hs.525017
3D structure databases
ModBase Q9BRP4.
Protein-protein interaction databases
IntAct Q9BRP4; -.
Organism-specific databases
HGNC HGNC:25687; PAAF1.
GenAtlas PAAF1.
PharmGKB PA142670604; -.
GeneCards Q9BRP4.
Gene expression databases
ArrayExpress Q9BRP4; -.
CleanEx HS_PAAF1; -.
GermOnline ENSG00000175575; Homo sapiens.
Ontologies
GO
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.
Family and domain databases
InterPro IPR015943; WD40/YVTN_repeat-like.
IPR001680; WD40_repeat.
Graphical view of domain structure.
Gene3D G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
Pfam PF00400; WD40; 3.
Pfam graphical view of domain structure.
PRINTS PR00320; GPROTEINBRPT.
ProDom PD000018; WD40; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00320; WD40; 6.
SMART graphical view of domain structure.
PROSITE PS00678; WD_REPEATS_1; 1.
PS50082; WD_REPEATS_2; 3.
PS50294; WD_REPEATS_REGION; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q9BRP4.
Genome annotation databases
Ensembl ENSG00000175575; Homo sapiens. [Contig view]
GeneID 80227; -.
KEGG hsa:80227; -.
Phylogenomic databases
HOVERGEN Q9BRP4; -.
Other
ProtoNet Q9BRP4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Host-virus interaction; Polymorphism; Proteasome; Repeat; WD repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   392  392     Proteasomal ATPase-associated factor 1. PRO_0000235685
REPEAT   90   129  40     WD 1. 
REPEAT   132   171  40     WD 2. 
REPEAT   174   215  42     WD 3. 
REPEAT   278   316  39     WD 4. 
REPEAT   360   392  33     WD 5. 
VAR_SEQ   1    30        MAAPLRIQSDWAQALRKDEGEAWLSCHPPG -> MLVPCFLYSLQNR (in isoform 2). VSP_018477
VARIANT   53    53  1     A -> V (in dbSNP:rs17850051 [NCBI]). VAR_026415 
VARIANT   139   139  1     C -> S (in dbSNP:rs2067912 [NCBI]). VAR_032082 
VARIANT   209   209  1     A -> G (in dbSNP:rs3741138 [NCBI]). VAR_026416 
Sequence information
Length: 392 AA [This is the length of the unprocessed precursor] Molecular weight: 42190 Da [This is the MW of the unprocessed precursor] CRC64: 54ECB1DEC1841B49 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAPLRIQSD WAQALRKDEG EAWLSCHPPG KPSLYGSLTC QGIGLDGIPE VTASEGFTVN 

        70         80         90        100        110        120 
EINKKSIHIS CPKENASSKF LAPYTTFSRI HTKSITCLDI SSRGGLGVSS STDGTMKIWQ 

       130        140        150        160        170        180 
ASNGELRRVL EGHVFDVNCC RFFPSGLVVL SGGMDAQLKI WSAEDASCVV TFKGHKGGIL 

       190        200        210        220        230        240 
DTAIVDRGRN VVSASRDGTA RLWDCGRSAC LGVLADCGSS INGVAVGAAD NSINLGSPEQ 

       250        260        270        280        290        300 
MPSEREVGTE AKMLLLARED KKLQCLGLQS RQLVFLFIGS DAFNCCTFLS GFLLLAGTQD 

       310        320        330        340        350        360 
GNIYQLDVRS PRAPVQVIHR SGAPVLSLLS VRDGFIASQG DGSCFIVQQD LDYVTELTGA 

       370        380        390 
DCDPVYKVAT WEKQIYTCCR DGLVRRYQLS DL 

Q9BRP4 in FASTA format

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