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UniProtKB/Swiss-Prot entry Q96DT6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG4C_HUMAN
Primary accession number Q96DT6
Secondary accession numbers A6NLR8 Q96K04
Integrated into Swiss-Prot on March 15, 2005
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 47)
Name and origin of the protein
Protein name Cysteine protease ATG4C
Synonyms EC 3.4.22.-
Autophagy-related protein 4 homolog C
Autophagin-3
Autophagy-related cysteine endopeptidase 3
AUT-like 3 cysteine endopeptidase
Gene name
Name: ATG4C
Synonyms: APG4C, AUTL1, AUTL3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Brain;
DOI=10.1074/jbc.M208247200; PubMed=12446702 [NCBI, ExPASy, EBI, Israel, Japan]
Marino G., Uria J.A., Puente X.S., Quesada V., Bordallo J., Lopez-Otin C.;
"Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.";
J. Biol. Chem. 278:3671-3678(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
Chen J.M., Barrett A.J.;
"Cloning and sequencing of a human homologue of the yeast Apg4 cysteine endopeptidase involved in autophagy.";
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04727; PubMed=16710414 [NCBI, ExPASy, EBI, Israel, Japan]
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ312234; CAC85556.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ320169; CAC43939.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027773; BAB55356.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC103923; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
CH471059; EAX06579.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC033024; AAH33024.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_116241.2; -.
NP_835739.1; -.
UniGene Hs.7353
3D structure databases
ModBase Q96DT6.
Protein family/group databases
MEROPS C54.004; -.
Organism-specific databases
H-InvDB HIX0000660; -.
HGNC HGNC:16040; ATG4C.
GenAtlas ATG4C.
HPA HPA007049; -.
MIM 611339; gene. [NCBI / EBI]
PharmGKB PA25183; -.
GeneCards Q96DT6.
Gene expression databases
ArrayExpress Q96DT6; -.
CleanEx HS_ATG4C; -.
GermOnline ENSG00000125703; Homo sapiens.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from sequence or structural similarity from UniProtKB).
GO:0005576; Cellular component: extracellular region (inferred from direct assay from UniProtKB).
GO:0005875; Cellular component: microtubule associated complex (inferred from sequence or structural similarity from UniProtKB).
GO:0004197; Molecular function: cysteine-type endopeptidase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0008017; Molecular function: microtubule binding (inferred from sequence or structural similarity from UniProtKB).
GO:0000045; Biological process: autophagosome formation (inferred from sequence or structural similarity from UniProtKB).
GO:0006612; Biological process: protein targeting to membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0006623; Biological process: protein targeting to vacuole (inferred from sequence or structural similarity from UniProtKB).
GO:0006508; Biological process: proteolysis (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR005078; Peptidase_C54.
Graphical view of domain structure.
PANTHER PTHR22624; Peptidase_C54; 1.
Pfam PF03416; Peptidase_C54; 1.
Pfam graphical view of domain structure.
BLOCKS Q96DT6.
Genome annotation databases
Ensembl ENSG00000125703; Homo sapiens. [Contig view]
GeneID 84938; -.
KEGG hsa:84938; -.
Phylogenomic databases
HOGENOM Q96DT6; -.
HOVERGEN Q96DT6; -.
Other
SOURCE ATG4C; Homo sapiens.
ProtoNet Q96DT6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Autophagy; Cytoplasm; Hydrolase; Protease; Protein transport; Thiol protease; Transport; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   458  458     Cysteine protease ATG4C. PRO_0000215849
ACT_SITE   111   111        Nucleophile (By similarity). 
ACT_SITE   345   345        Potential. 
ACT_SITE   347   347        By similarity. 
Sequence information
Length: 458 AA [This is the length of the unprocessed precursor] Molecular weight: 52497 Da [This is the MW of the unprocessed precursor] CRC64: 6A23A05E7F20AF27 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEATGTDEVD KLKTKFISAW NNMKYSWVLK TKTYFSRNSP VLLLGKCYHF KYEDEDKTLP 

        70         80         90        100        110        120 
AESGCTIEDH VIAGNVEEFR KDFISRIWLT YREEFPQIEG SALTTDCGWG CTLRTGQMLL 

       130        140        150        160        170        180 
AQGLILHFLG RAWTWPDALN IENSDSESWT SHTVKKFTAS FEASLSGERE FKTPTISLKE 

       190        200        210        220        230        240 
TIGKYSDDHE MRNEVYHRKI ISWFGDSPLA LFGLHQLIEY GKKSGKKAGD WYGPAVVAHI 

       250        260        270        280        290        300 
LRKAVEEARH PDLQGITIYV AQDCTVYNSD VIDKQSASMT SDNADDKAVI ILVPVRLGGE 

       310        320        330        340        350        360 
RTNTDYLEFV KGILSLEYCV GIIGGKPKQS YYFAGFQDDS LIYMDPHYCQ SFVDVSIKDF 

       370        380        390        400        410        420 
PLETFHCPSP KKMSFRKMDP SCTIGFYCRN VQDFKRASEE ITKMLKFSSK EKYPLFTFVN 

       430        440        450 
GHSRDYDFTS TTTNEEDLFS EDEKKQLKRF STEEFVLL 

Q96DT6 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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