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UniProtKB/Swiss-Prot entry Q90ZK6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACVR1_CHICK
Primary accession number Q90ZK6
Secondary accession number Q9YH45
Integrated into Swiss-Prot on October 17, 2006
Sequence was last modified on December 1, 2001 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Activin receptor type-1 [Precursor]
Synonyms EC 2.7.11.30
Activin receptor type I
Type I TGF B receptor
Gene name
Name: ACVR1
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Leghorn;
TISSUE=Heart;
Brames G.P., Barnett J.V.;
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Derco brown;
Kuchler K.;
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U38622; AAC98806.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ318064; CAC39433.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_989891.1; -.
UniGene Gga.2875
3D structure databases
HSSP P36897; 1IAS. [HSSP ENTRY / PDB]
ModBase Q90ZK6.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00467; GS; 1.
SMART graphical view of domain structure.
PROSITE PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q90ZK6.
Genome annotation databases
Ensembl ENSGALG00000012551; Gallus gallus. [Contig view]
GeneID 395246; -.
KEGG gga:395246; -.
Phylogenomic databases
HOVERGEN Q90ZK6; -.
Other
ProtoNet Q90ZK6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    16  16     Potential. 
CHAIN   17   504  488     Activin receptor type-1. PRO_0000253593
TOPO_DOM   17   119  103     Extracellular (Potential). 
TRANSMEM   120   140  21     Potential. 
TOPO_DOM   141   504  364     Cytoplasmic (Potential). 
DOMAIN   173   202  30     GS. 
DOMAIN   203   497  295     Protein kinase. 
NP_BIND   209   217  9     ATP (By similarity). 
ACT_SITE   331   331        Proton acceptor (By similarity). 
BINDING   230   230        ATP (By similarity). 
CARBOHYD   94    94        N-linked (GlcNAc...) (Potential). 
CONFLICT   211   212        KG -> SN (in Ref. 2; AAC98806). 
Sequence information
Length: 504 AA [This is the length of the unprocessed precursor] Molecular weight: 56225 Da [This is the MW of the unprocessed precursor] CRC64: C7F045D6A25A071E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MALPVLLLLL ALPSRSVQDE ELKLNECVCE GMSCGNGDRC QGQQCFASLS INDGAKVYQK 

        70         80         90        100        110        120 
GCFQVYEQGK MTCKTPPSPD QAVECCQGYL CNMNITAKLP SSKGQTLQGE AAGYSMETLI 

       130        140        150        160        170        180 
IVILAPVVVL VIFSVVAVLI IRRIQKNHME RLNSRDAEYG TIEGLIASNV GDSTLADLLD 

       190        200        210        220        230        240 
HSCTSGSGSG LPFLVQRTVA RQITLVECVG KGRYGEVWRG QWQGENVAVK IFSSRDEKSW 

       250        260        270        280        290        300 
FRETELYNTV LLRHENILGF IASDMTSRNS STQLWLITHY HEMGSLYDYL QLTTLDTVSC 

       310        320        330        340        350        360 
LRIVLSIASG LAHLHIEIFG TQGKPAISHR DLKSKNILVK KNGQCCIADL GLAVMHSQST 

       370        380        390        400        410        420 
NQLDVGNNPR VGTKRYMAPE VLDETIQADC FDSYKRVDIW AFGLVLWEVA RRMVSNGIVE 

       430        440        450        460        470        480 
DYKPPFYDLV PNDPSFEDMR KVVCVDQQRP NIPNRWFSDP TLTSLAKLMK ECWYQNPSAR 

       490        500 
LTALRIKKTL TKIDNSLDKL KADC
Q90ZK6 in FASTA format

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