ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8VCZ6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name SGSM3_MOUSE
Primary accession number Q8VCZ6
Secondary accession number Q3TCB6
Integrated into Swiss-Prot on October 23, 2007
Sequence was last modified on March 1, 2002 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 49)
Name and origin of the protein
Protein name Small G protein signaling modulator 3
Synonym RUN and TBC1 domain-containing protein 3
Gene name
Name: Sgsm3
Synonyms: Cip85, Rutbc3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH GJA1.
TISSUE=Embryo;
DOI=10.1021/bi048306w; PubMed=15709751 [NCBI, ExPASy, EBI, Israel, Japan]
Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.;
"Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation.";
Biochemistry 44:2385-2396(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=NOD;
TISSUE=Dendritic cell;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver, Mammary tumor, and Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
DOI=10.1016/j.ygeno.2007.03.013; PubMed=17509819 [NCBI, ExPASy, EBI, Israel, Japan]
Yang H., Sasaki T., Minoshima S., Shimizu N.;
"Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.";
Genomics 90:249-260(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-410, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[6]
STRUCTURE BY NMR OF 483-549.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3.";
Submitted (OCT-2007) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY382616; AAR89983.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK170806; BAE42041.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018197; AAH18197.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024122; AAH24122.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC025561; AAH25561.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_598852.1; -.
UniGene Mm.274943
3D structure databases
PDB
2YUO; NMR; -; A=483-549.[ExPASy / RCSB / EBI]
PDBsum 2YUO; -.
ModBase Q8VCZ6.
Protein-protein interaction databases
IntAct Q8VCZ6; 1.
PTM databases
PhosphoSite Q8VCZ6; -.
Organism-specific databases
MGI MGI:1916329; Sgsm3.
Gene expression databases
ArrayExpress Q8VCZ6; -.
CleanEx MM_SGSM3; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005921; Cellular component: gap junction (inferred from direct assay from UniProtKB).
GO:0005097; Molecular function: Rab GTPase activator activity (inferred from electronic annotation from InterPro).
GO:0017137; Molecular function: Rab GTPase binding (inferred from sequence or structural similarity from UniProtKB).
GO:0007050; Biological process: cell cycle arrest (inferred from electronic annotation from UniProtKB-KW).
GO:0045732; Biological process: positive regulation of protein catabolic process (inferred from direct assay from UniProtKB).
GO:0032486; Biological process: Rap protein signal transduction (inferred from sequence or structural similarity from UniProtKB).
GO:0032313; Biological process: regulation of Rab GTPase activity (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000195; RabGAP_TBC.
IPR004012; Run.
IPR001452; SH3.
Graphical view of domain structure.
Pfam PF02759; RUN; 1.
PF00018; SH3_1; 1.
PF00566; TBC; 1.
Pfam graphical view of domain structure.
PRINTS PR00452; SH3DOMAIN.
ProDom PD000066; SH3; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00593; RUN; 1.
SM00326; SH3; 1.
SM00164; TBC; 1.
SMART graphical view of domain structure.
PROSITE PS50826; RUN; 1.
PS50002; SH3; 1.
PS50086; TBC_RABGAP; 1.
PROSITE graphical view of domain structure (profiles).
Proteomics databases
PRIDE Q8VCZ6; -.
Genome annotation databases
Ensembl ENSMUSG00000042303; Mus musculus. [Contig view]
GeneID 105835; -.
KEGG mmu:105835; -.
NMPDR fig|10090.3.peg.30296; -.
Phylogenomic databases
HOVERGEN Q8VCZ6; -.
Other
NextBio 357910; -.
SOURCE Sgsm3; Mus musculus.
ProtoNet Q8VCZ6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cell cycle; Coiled coil; Cytoplasm; Growth arrest; Phosphoprotein; SH3 domain.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   750  750     Small G protein signaling modulator 3. PRO_0000307811
DOMAIN   114   305  192     Rab-GAP TBC. 
DOMAIN   480   539  60     SH3. 
DOMAIN   555   718  164     RUN. 
COILED   415   439  25     Potential. 
MOD_RES   410   410        Phosphoserine. 
CONFLICT   622   622        D -> G (in Ref. 2; BAE42041). 
STRAND   483   489  7      
STRAND   506   511  6      
STRAND   514   522  9      
STRAND   525   530  6      
HELIX   531   533  3      
STRAND   534   537  4      
Sequence information
Length: 750 AA [This is the length of the unprocessed precursor] Molecular weight: 85490 Da [This is the MW of the unprocessed precursor] CRC64: C0306BE346808B07 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV DKEGSEPGCS 

        70         80         90        100        110        120 
QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS LPRSEKLRSL VLAGIPHGMR 

       130        140        150        160        170        180 
PQLWMRLSGA LQKKKNSELS YREIIKNSSN DETIAAKQIE KDLLRTMPSN ACFANVNSIG 

       190        200        210        220        230        240 
VPRLRRVLRA LAWLYPEIGY CQGTGMVAAC LLLFLEEEDA FWMMCAIIED LLPASYFSTT 

       250        260        270        280        290        300 
LLGVQTDQRV LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVH IRLLLRIWDL 

       310        320        330        340        350        360 
FFYEGSLVLF QTTLGMLRLK EEELIQSENS ASIFNTLSDI PAQMDDAELL LGEAMRLAGS 

       370        380        390        400        410        420 
LTDVAVETQR RKHLAYLIAD QGQTLGTGTT TNLSQVVRRR TQRRKSGITS LLFGEDDLEA 

       430        440        450        460        470        480 
LKAKNIKQTE LVADLREAIL RVARHFQCTD PKNCSVELTP DYSMESHQRD HENYVACLRS 

       490        500        510        520        530        540 
HRRRAKALLD FERHDDDELG FRKNDIITII SQKDEHCWVG ELNGLRGWFP AKFVEVLDER 

       550        560        570        580        590        600 
SKEYSIAGDD SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV 

       610        620        630        640        650        660 
ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM DVKLRSLICV 

       670        680        690        700        710        720 
GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK CELRVLCCFA FSLSQDWELP 

       730        740        750 
ARREEEKQPL KEGVQDMLVK HHLFSWDIDG 

Q8VCZ6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by au flag APAF Australia Mirror sites: Brazil  Canada  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!