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UniProtKB/Swiss-Prot entry Q8N2K1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UB2J2_HUMAN
Primary accession number Q8N2K1
Secondary accession numbers Q96N26 Q96T84
Integrated into Swiss-Prot on September 13, 2004
Sequence was last modified on September 13, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Ubiquitin-conjugating enzyme E2 J2
Synonyms EC 6.3.2.19
Non-canonical ubiquitin-conjugating enzyme 2
NCUBE2
Gene name
Name: UBE2J2
Synonyms: NCUBE2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1074/jbc.M007640200; PubMed=11278356 [NCBI, ExPASy, EBI, Israel, Japan]
Tiwari S., Weissman A.M.;
"Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s).";
J. Biol. Chem. 276:16193-16200(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Ovary;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF296658; AAK52609.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK056065; BAB71086.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK075017; BAC11355.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_477515.2; -.
NP_919440.1; -.
UniGene Hs.191987
3D structure databases
PDB
2F4W; X-ray; 2.00 A; A/B=1-185.[ExPASy / RCSB / EBI]
PDBsum 2F4W; -.
SMR Q8N2K1; 11-171.
ModBase Q8N2K1.
Organism-specific databases
HGNC HGNC:19268; UBE2J2.
GenAtlas UBE2J2.
PharmGKB PA134882268; -.
GeneCards Q8N2K1.
Gene expression databases
ArrayExpress Q8N2K1; -.
CleanEx HS_UBE2J2; -.
GermOnline ENSG00000160087; Homo sapiens.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004842; Molecular function: ubiquitin-protein ligase activity (inferred from electronic annotation from EC).
GO:0043687; Biological process: post-translational protein modification (inferred from electronic annotation from InterPro).
GO:0051246; Biological process: regulation of protein metabolic process (inferred from electronic annotation from InterPro).
GO:0006511; Biological process: ubiquitin-dependent protein catabolic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016135; UBQ-conjugat/RWD-like.
IPR000608; UBQ-conjugat_E2.
Graphical view of domain structure.
Gene3D G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
PANTHER PTHR11621; UBQ-conjugat_E2; 1.
Pfam PF00179; UQ_con; 1.
Pfam graphical view of domain structure.
ProDom PD000461; UBQ_conjugat; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00212; UBCc; 1.
SMART graphical view of domain structure.
PROSITE PS00183; UBIQUITIN_CONJUGAT_1; FALSE_NEG.
PS50127; UBIQUITIN_CONJUGAT_2; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8N2K1.
Genome annotation databases
Ensembl ENSG00000160087; Homo sapiens. [Contig view]
GeneID 118424; -.
KEGG hsa:118424; -.
Phylogenomic databases
HOVERGEN Q8N2K1; -.
Other
NextBio 80253; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Endoplasmic reticulum; Ligase; Membrane; Transmembrane; Ubl conjugation pathway.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   259  259     Ubiquitin-conjugating enzyme E2 J2. PRO_0000082596
TOPO_DOM   1   226  226     Cytoplasmic (Potential). 
TRANSMEM   227   247  21     Anchor for type IV membrane protein (Potential). 
TOPO_DOM   248   259  12     Lumenal (Potential). 
ACT_SITE   94    94        Glycyl thioester intermediate (By similarity). 
VAR_SEQ   1    44        MNSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPS NILEW -> MWPQDIAGR (in isoform 2). VSP_011572
CONFLICT   2     2        N -> S (in Ref. 1; AAK52609). 
CONFLICT   100   100        F -> S (in Ref. 2; BAC11355). 
CONFLICT   214   238        PNLAGLQQANRHHGLLGGALANLFV -> QTSQGSSRPTGTTDSGWRPGELVC (in Ref. 1; AAK52609). 
HELIX   13    26  14      
STRAND   32    37  6      
STRAND   40    49  10      
TURN   55    58  4      
STRAND   60    66  7      
TURN   69    72  4      
STRAND   77    80  4      
STRAND   85    87  3      
HELIX   111   123  13      
HELIX   136   151  16      
HELIX   154   159  6      
HELIX   161   167  7      
Sequence information
Length: 259 AA [This is the length of the unprocessed precursor] Molecular weight: 28925 Da [This is the MW of the unprocessed precursor] CRC64: 7DB1023D294C177E [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNSTSSKRAP TTATQRLKQD YLRIKKDPVP YICAEPLPSN ILEWHYVVRG PEMTPYEGGY 

        70         80         90        100        110        120 
YHGKLIFPRE FPFKPPSIYM ITPNGRFKCN TRLCLSITDF HPDTWNPAWS VSTILTGLLS 

       130        140        150        160        170        180 
FMVEKGPTLG SIETSDFTKR QLAVQSLAFN LKDKVFCELF PEVVEEIKQK QKAQDELSSR 

       190        200        210        220        230        240 
PQTLPLPDVV PDGETHLVQN GIQLLNGHAP GAVPNLAGLQ QANRHHGLLG GALANLFVIV 

       250 
GFAAFAYTVK YVLRSIAQE 

Q8N2K1 in FASTA format

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