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UniProtKB/Swiss-Prot entry Q8K9U9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AKH_BUCAP
Primary accession number Q8K9U9
Secondary accession numbers None
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Bifunctional aspartokinase/homoserine dehydrogenase
Synonym AK-HD
Includes Aspartokinase
     (EC 2.7.2.4)
Homoserine dehydrogenase
     (EC 1.1.1.3)
Gene name
Name: thrA
OrderedLocusNames: BUsg_188
From
Buchnera aphidicola subsp. Schizaphis graminum [TaxID: 98794] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1071278; PubMed=12089438 [NCBI, ExPASy, EBI, Israel, Japan]
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
"50 million years of genomic stasis in endosymbiotic bacteria.";
Science 296:2376-2379(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013218; AAM67753.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_660542.1; -.
3D structure databases
HSSP P31116; 1EBF. [HSSP ENTRY / PDB]
ModBase Q8K9U9.
Enzyme and pathway databases
BioCyc BAPH198804:BUSG188-MON; -.
Family and domain databases
InterPro IPR001048; Asp/Glu/Uridylate_kinase.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001341; Asp_kin_reg.
IPR011147; bifunc_aspartokin/hSer_DHase.
IPR001342; hSer_DHase_cat.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00696; AA_kinase; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000727; ThrA; 1.
TIGRFAMs TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
PS01042; HOMOSER_DHGENASE; 1.
BLOCKS Q8K9U9.
Genome annotation databases
GeneID 1005385; -.
GenomeReviews AE013218_GR; BUsg_188.
KEGG bas:BUsg188; -.
Phylogenomic databases
HOGENOM Q8K9U9; -.
Genome annotation databases
CMR Q8K9U9; BUsg_188.
Other
ProtoNet Q8K9U9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; NADP; Oxidoreductase; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   814  814     Bifunctional aspartokinase/homoserine dehydrogenase. PRO_0000066685
NP_BIND   470   477  8     NADP (Potential). 
REGION   1   248  248     Aspartokinase (By similarity). 
REGION   249   469  221     Interface (By similarity). 
REGION   470   814  345     Homoserine dehydrogenase (By similarity). 
Sequence information
Length: 814 AA [This is the length of the unprocessed precursor] Molecular weight: 91379 Da [This is the MW of the unprocessed precursor] CRC64: 162CDD52590D1A00 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKLLKFGGTS LANAKKFLCV ADIIEKKNKK EQIAVVLSAP AKITNYLATI IENKIDDEVL 

        70         80         90        100        110        120 
KKINLAKNIF IELIQDIKRI QPLFPYENTK STIEIEFNKL KKIINGILLI KQCPEGIKPI 

       130        140        150        160        170        180 
IISRGEILSV DIMKNILQSR NHEVTILNPV TNLLSIGNYL DSTIDIKESK KRIKKINIDQ 

       190        200        210        220        230        240 
KNIILMAGFI AGNKEGELVV LGRNGSDYSA AILASCLNAK CCEIWTDVDG VLTADPRIVS 

       250        260        270        280        290        300 
NTYLLDYISY QEAMELSYFG AKVLHPRTIE PISQFQIPCV IKNTNNTESK GTWIGKENNP 

       310        320        330        340        350        360 
SDNSLKGVTY LDNIIMFNIS GSCLKDSGNT IARIFTILSR ESMKIILIIQ SSSENQINFC 

       370        380        390        400        410        420 
TFEKDIDYIL LILKKEFTLE IKEGLLNDFN IVKNLTILSV IGSNISEKNN IASKIFSSLG 

       430        440        450        460        470        480 
SSKINVLAIA HGSSKHSISI VIKKENLLQG IQNIHNTLFF KKTIINVFLI GIGGVGKALL 

       490        500        510        520        530        540 
KQILKQEKFL DQKNIKIQFR MIANSKKLLF LKNSINLNNW EENFKKSKEK FNLTILNELL 

       550        560        570        580        590        600 
KNTCDSNSVI IDCTSDYILS KQYISFIKKG FHIITSNKKA NTDSLKYYSE IRTTALKENK 

       610        620        630        640        650        660 
KFLYETNVGA GLPVINTLQS LFSTGDCLIS FKGILSGSLS FIFGKLEEGV LLSEATKEAK 

       670        680        690        700        710        720 
KLGFTEPNPF DDLSGIDVAR KLLVLAREIG YSIELKDISI EPILPERFKK YQNSEEFLFK 

       730        740        750        760        770        780 
LKELDSFFSE RVNKARDIGN VLRFIGSIEK NGKCSVKIEE INSNNPLYKV KNGENALTFY 

       790        800        810 
TNYYQPIPLV LRGYGAGNDV TASGVFSDLL RIIL
Q8K9U9 in FASTA format

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