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UniProtKB/Swiss-Prot entry Q75HE6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTHR_ORYSJ
Primary accession number Q75HE6
Secondary accession number Q75GR7
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 28)
Name and origin of the protein
Protein name Probable methylenetetrahydrofolate reductase
Synonym EC 1.5.1.20
Gene name
OrderedLocusNames: Os03g0815200, LOC_Os03g60090
ORFNames: OSJNBa0024F18.2, OSJNBb0042K11.1
From
Oryza sativa subsp. japonica (Rice) [TaxID: 39947] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
DOI=10.1101/gr.3869505; PubMed=16109971 [NCBI, ExPASy, EBI, Israel, Japan]
The rice chromosome 3 sequencing consortium;
Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H.-I., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.;
"Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species.";
Genome Res. 15:1284-1291(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Nipponbare;
DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan]
The rice full-length cDNA consortium;
"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.";
Science 301:376-379(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AC135594; AAR89836.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC139172; AAR01748.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK062082; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
AK099527; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
AK121351; -; NOT_ANNOTATED_CDS; mRNA.[EMBL / GenBank / DDBJ]
RefSeq NP_001051683.1; -.
UniGene Os.7657
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
ModBase Q75HE6.
Organism-specific databases
Gramene Q75HE6; -.
Ontologies
GO
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR004621; Fadh2_euk.
IPR003171; Mehydrof_redctse.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00677; fadh2_euk; 1.
BLOCKS Q75HE6.
ProtoNet Q75HE6.
Genome annotation databases
GeneID 4334554; -.
KEGG osa:4334554; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   594  594     Probable methylenetetrahydrofolate reductase. PRO_0000190252
CONFLICT   5     5        E -> G (in Ref. 2; AK121351). 
CONFLICT   404   404        G -> R (in Ref. 2; AK099527). 
Sequence information
Length: 594 AA [This is the length of the unprocessed precursor] Molecular weight: 66431 Da [This is the MW of the unprocessed precursor] CRC64: C576C748AA847A18 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKVIEKIQEA AADGRTVFSF EYFPPKTEEG LDNLFERMDR MVAHGPNFCD ITWGAGGSTA 

        70         80         90        100        110        120 
DLTLEIANRM QNMVCVETMM HLTCTNMPVE KIDDALTTIK SNGIQNVLAL RGDPPHGQDK 

       130        140        150        160        170        180 
FVQVAGGFAC ALDLVQHIRA KYGDYFGITV AGYPEAHPDA IQSTEGATPE AYSNDLAYLK 

       190        200        210        220        230        240 
QKVDAGADLI ITQLFYDTDI FLKFVNDCRQ IGITCPIVPG IMPINNYKGF LRMTGFCKTK 

       250        260        270        280        290        300 
IPAEITAALE PIKDNEEAVK AYGIHLGTEM CKKILATGIK TLHLYTLNME KSALGILMNL 

       310        320        330        340        350        360 
GLIEESKISR SLPWRPPTNV FRVKEDVRPI FWANRPKSYI SRTLGWDQYP HGRWGDSRNP 

       370        380        390        400        410        420 
SYGALTDYQF TRPRGRGKKL QEEWAVPVKS VEDINERFMN FCQGKLTSSP WSELDGLQPE 

       430        440        450        460        470        480 
TKIIDDQLVK INQKGFLTIN SQPAVNGERS DSTSVGWGGP GGYVYQKAYL EFFCSKEKLD 

       490        500        510        520        530        540 
QLIEKSKAFP SLTYIAVNKD GESFSNIPTN AVNAVTWGVF PGKEIVQPTV VDSASFMVWK 

       550        560        570        580        590 
DEAFEIWSKG WACLFPEGDS SREILDKVQK SYFLVSLVDN DYINGDLFAA FKEI 

Q75HE6 in FASTA format

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