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UniProtKB/Swiss-Prot entry Q64415

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_GEOKN
Primary accession number Q64415
Secondary accession number Q64416
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 4, 2008 (Entry version 53)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Alcohol dehydrogenase A subunit
Gene name
Name: ADH1
From
Geomys knoxjonesi (Knox Jones's pocket gopher) [TaxID: 27683] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Geomyidae; Geomys.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ALA-30.
STRAIN=Isolate TK 30715;
TISSUE=Liver;
PubMed=8415634 [NCBI, ExPASy, EBI, Israel, Japan]
Bradley R.D., Bull J.J., Johnson A.D., Hillis D.M.;
"Origin of a novel allele in a mammalian hybrid zone.";
Proc. Natl. Acad. Sci. U.S.A. 90:8939-8941(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L15461; AAA03600.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L15462; AAA03599.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I60973; I60973.
3D structure databases
HSSP P00327; 1HEU. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR Q64415; 2-375.
ModBase Q64415.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS Q64415.
ProtoNet Q64415.
Phylogenomic databases
HOVERGEN Q64415; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   375  374     Alcohol dehydrogenase 1. PRO_0000160655
METAL   47    47        Zinc 1; catalytic (By similarity). 
METAL   68    68        Zinc 1; catalytic (By similarity). 
METAL   98    98        Zinc 2 (By similarity). 
METAL   101   101        Zinc 2 (By similarity). 
METAL   104   104        Zinc 2 (By similarity). 
METAL   112   112        Zinc 2 (By similarity). 
METAL   175   175        Zinc 1; catalytic (By similarity). 
VARIANT   30    30  1     V -> A. 
Sequence information
Length: 375 AA [This is the length of the unprocessed precursor] Molecular weight: 39943 Da [This is the MW of the unprocessed precursor] CRC64: EC882C191A9413C2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTAGKVIKC RAAVLWEKNK PFSIEEVEVV PPKAYEVRIK IVATGICRSD DHVVNGSIIT 

        70         80         90        100        110        120 
PLPAILGHEA GGIVESIGEG VTTVKPGDKV IPLFVPQCGK CRACKHPESN LCTHGDLGRA 

       130        140        150        160        170        180 
QGTLMDGTSR FTCKGKPIHH FLGVTTFSEY TVVSEISVTK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVGKV ARGSICSCVW SGRVGLSAII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CVNPQDYDKP IYQVLQEMTD GGVDFSFEVI GRLDTMVSAL MCCQESHGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLTMDPMVLL SGRSWKGAVF GGYKGKDDVP KLVADFMAKK FPLEPLITNV FPFAKINEGF 

       370 
DLLRAGKSIR TVLTF
Q64415 in FASTA format

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