[1]	NUCLEOTIDE SEQUENCE [MRNA]. Pinteric M., Baumgart E., Bulitta C., Fahimi D., Voelkl A.; "Molecular characterization of guinea pig catalase."; Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-138. STRAIN=Hartley; TISSUE=Lung; DOI=10.1016/0167-4781(95)00214-6; PubMed=8597602 [NCBI, ExPASy, EBI, Israel, Japan] Yuan H.T., Bingle C.D., Kelly F.J.; "Differential patterns of antioxidant enzyme mRNA expression in guinea pig lung and liver during development."; Biochim. Biophys. Acta 1305:163-171(1996).

Comments

FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group (By similarity).
COFACTOR: NADP (By similarity).
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Peroxisome (By similarity).
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ005111; CAB57222.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U39841; AAC52717.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P00432; 4BLC. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

SMR

Q64405; 5-501.

ModBase

Q64405.

Ontologies

GO:0005777;	Cellular component: peroxisome (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0042744;	Biological process: hydrogen peroxide catabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.
PS51402; CATALASE_3; 1.
PROSITE graphical view of domain structure (profiles).

Phylogenomic databases

HOVERGEN

Q64405; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; NADP; Oxidoreductase; Peroxidase; Peroxisome; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 527`	`526`	`Catalase.`	`PRO_0000084900`
`ACT_SITE`	`75 75`		`By similarity.`
`ACT_SITE`	`148 148`		`By similarity.`
`METAL`	`358 358`		`Iron (heme axial ligand) (By similarity).`
`MOD_RES`	`231 231`		`Phosphotyrosine (By similarity).`
`MOD_RES`	`308 308`		`Phosphotyrosine (By similarity).`
`MOD_RES`	`517 517`		`Phosphoserine (By similarity).`
`CONFLICT`	`9 9`		`Missing (in Ref. 2; AAC52717).`
`CONFLICT`	`83 83`		`A -> G (in Ref. 2; AAC52717).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 59934 Da [This is the MW of the unprocessed precursor]

CRC64: 7C53CDD76255F9A8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADSRDPASD QMKHWKEERA AQKPDVLTTA GGNPVGDKLN IMTVGPRGPL LVQDVVFTDE 

        70         80         90        100        110        120 
MAHFDRERIP ERVVHAKGAG AFAYFEVTHD ITKYCKAKVF EHIGKKTPIA VRFSTVAGES 

       130        140        150        160        170        180 
GSADTVRDPR GFAVKFYTEE GIWDLVGNNT PIFFIRDALL FPSFIHSQKR NPQTHLKDPD 

       190        200        210        220        230        240 
MMWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNGSGEAV YCKFHYKTDQ 

       250        260        270        280        290        300 
GIKNLSVEDA ARLSQEDPDY GLRDLFNAIA TGNYPSWTLY IQVMTFQQAQ SFPFNPFDLT 

       310        320        330        340        350        360 
KIWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEPSPDKM LQGRLFAYPD 

       370        380        390        400        410        420 
THRHRLGPNY LQIPVNCPYR TRVANYQRDG PMCVTDNQGG APNYYPNSFS APVEQRQALE 

       430        440        450        460        470        480 
HTSRCSGDVG RYNSTDDDNV TQVRAFYTQV LNEEQRRRLC ENIAGHLKDA QLFIQKKAVK 

       490        500        510        520 
NFMDVHPDYG NRIQTLLDKY NVEKPKNAIH TFVQDGSHLS AKEKANL

Q64405 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools