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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2472388 [NCBI, ExPASy, EBI, Israel, Japan]
Elferink L.A.,
Trimble W.S.,
Scheller R.H.;
"Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system.";
J. Biol. Chem. 264:11061-11064(1989).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0378-1119(97)00244-8; PubMed=9358054 [NCBI, ExPASy, EBI, Israel, Japan]
Mandic R.,
Trimble W.S.,
Lowe A.W.;
"Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1).";
Gene 199:173-179(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
STRAIN=Wistar;
TISSUE=Osteoblast;
DOI=10.1006/excr.2002.5668; PubMed=12490191 [NCBI, ExPASy, EBI, Israel, Japan]
Prele C.M.,
Horton M.A.,
Caterina P.,
Stenbeck G.;
"Identification of the molecular mechanisms contributing to polarized trafficking in osteoblasts.";
Exp. Cell Res. 282:24-34(2003).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
STRAIN=Brown Norway;
TISSUE=Cochlear nucleus;
Friedland D.R.,
Eernisse R.,
Popper P.;
"Identification of a novel Vamp1 splice variant in the cochlear nucleus containing intra-vesicular kinase recognition sites.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
- SUBUNIT: Interacts with VAPA and VAPB (By similarity).
- SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome (By similarity).
- SUBCELLULAR LOCATION: Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Note=Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
- SUBCELLULAR LOCATION: Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein. Note=Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
- ALTERNATIVE PRODUCTS:
4 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | Vamp1b |
| Isoform ID | Q63666-2 |
| Features which should be applied to build the isoform sequence: VSP_029188. |
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| Name | 3 |
| Synonyms | Vamp1-ob |
| Isoform ID | Q63666-3 |
| Features which should be applied to build the isoform sequence: VSP_029187. |
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| Name | 4 |
| Isoform ID | Q63666-4 |
| Features which should be applied to build the isoform sequence: VSP_029189. |
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- TISSUE SPECIFICITY: Expressed in brain and spleen (at protein level). Isoform 1 expressed at very high level in brain. Even higher level found in spinal cord. Isoform 3 expressed in kidney, spleen and liver. Isoforms 2 and 3 expressed in osteoblasts of trabecular bone. Also expressed in heart.
- SIMILARITY: Belongs to the synaptobrevin family.
- SIMILARITY: Contains 1 v-SNARE coiled-coil homology domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 118 AA [This is the length of the unprocessed precursor] |
Molecular weight: 12797 Da [This is the MW of the unprocessed precursor] |
CRC64: E34D4D735CFBF6A8 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSAPAQPPAE GTEGAAPGGG PPGPPPNTTS NRRLQQTQAQ VEEVVDIMRV NVDKVLERDQ
70 80 90 100 110
KLSELDDRAD ALQAGASVFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYIFT
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Q63666 in FASTA format |
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