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UniProtKB/Swiss-Prot entry Q63639

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL1A2_RAT
Primary accession number Q63639
Secondary accession number Q4FZY8
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 72)
Name and origin of the protein
Protein name Retinal dehydrogenase 2
Synonyms RALDH 2
RalDH2
EC 1.2.1.36
Aldehyde dehydrogenase family 1 member A2
Retinaldehyde-specific dehydrogenase type 2
RALDH(II)
Gene name
Name: Aldh1a2
Synonyms: Raldh2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 4-518.
TISSUE=Testis;
DOI=10.1074/jbc.271.27.16288; PubMed=8663198 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X., Penzes P., Napoli J.L.;
"Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate.";
J. Biol. Chem. 271:16288-16293(1996).
[3]
 X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 20-518.
DOI=10.1021/bi9900471; PubMed=10320326 [NCBI, ExPASy, EBI, Israel, Japan]
Lamb A.L., Newcomer M.E.;
"The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity.";
Biochemistry 38:6003-6011(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC098910; AAH98910.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U60063; AAC52637.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_446348.1; -.
UniGene Rn.10514
3D structure databases
PDB
1BI9; X-ray; 2.70 A; A/B/C/D=20-518.[ExPASy / RCSB / EBI]
PDBsum 1BI9; -.
ModBase Q63639.
Organism-specific databases
RGD 620250; Aldh1a2.
Gene expression databases
ArrayExpress Q63639; -.
GermOnline ENSRNOG00000016042; Rattus norvegicus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0001758; Molecular function: retinal dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q63639.
ProtoNet Q63639.
Genome annotation databases
Ensembl ENSRNOG00000016042; Rattus norvegicus. [Contig view]
GeneID 116676; -.
KEGG rno:116676; -.
NMPDR fig|10116.3.peg.28888; -.
Phylogenomic databases
HOVERGEN Q63639; -.
Other
NextBio 619506; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   518  518     Retinal dehydrogenase 2. PRO_0000056424
NP_BIND   263   268  6     NAD (By similarity). 
ACT_SITE   286   286        Proton acceptor. 
ACT_SITE   320   320        Nucleophile. 
SITE   187   187  1     Transition state stabilizer. 
MOD_RES   119   119        Phosphothreonine (By similarity). 
MOD_RES   122   122        Phosphothreonine (By similarity). 
STRAND   39    42  4      
STRAND   45    47  3      
STRAND   54    58  5      
TURN   60    62  3      
STRAND   65    70  6      
HELIX   74    88  15      
STRAND   89    91  3      
HELIX   93    96  4      
HELIX   99   115  17      
HELIX   117   128  12      
HELIX   132   137  6      
HELIX   139   151  13      
TURN   152   155  4      
STRAND   159   162  4      
STRAND   165   176  12      
STRAND   179   183  5      
STRAND   186   188  3      
HELIX   189   202  14      
STRAND   206   210  5      
HELIX   217   229  13      
STRAND   235   238  4      
TURN   243   245  3      
HELIX   246   252  7      
STRAND   258   263  6      
HELIX   265   277  13      
STRAND   282   286  5      
STRAND   293   295  3      
HELIX   301   313  13      
HELIX   314   317  4      
STRAND   326   329  4      
HELIX   330   346  17      
HELIX   365   379  15      
TURN   380   382  3      
STRAND   384   387  4      
STRAND   393   396  4      
STRAND   402   406  5      
HELIX   412   415  4      
STRAND   420   428  9      
HELIX   431   439  9      
STRAND   445   450  6      
HELIX   454   463  10      
STRAND   467   472  6      
HELIX   499   501  3      
STRAND   504   512  9      
Sequence information
Length: 518 AA [This is the length of the unprocessed precursor] Molecular weight: 56640 Da [This is the MW of the unprocessed precursor] CRC64: 2BDDAABB0D2D066C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTSSEIAMPG EVKADPAALM ASLQLLPSPT PNLEIKYTKI FINNEWQNSE SGRVFPVCNP 

        70         80         90        100        110        120 
ATGEQVCEVQ EADKVDIDKA VQAARLAFSL GSVWRRMDAS ERGRLLDKLA DLVERDRATL 

       130        140        150        160        170        180 
ATMESLNGGK PFLQAFYIDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 

       190        200        210        220        230        240 
GQIIPWNFPL LMFTWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 

       250        260        270        280        290        300 
GYGPTAGAAI ASHIGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 

       310        320        330        340        350        360 
LDYAVEQAHQ GVFFNQGQCC TAGSRIFVEE SIYEEFVKRS VERAKRRIVG SPFDPTTEQG 

       370        380        390        400        410        420 
PQIDKKQYNK ILELIQSGVA EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 

       430        440        450        460        470        480 
PVQEILRFKT MDEVIERANN SDFGLVAAVF TNDINKALMV SSAMQAGTVW INCYNALNAQ 

       490        500        510 
SPFGGFKMSG NGREMGEFGL REYSEVKTVT VKIPQKNS
Q63639 in FASTA format

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