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UniProtKB/Swiss-Prot entry Q62730

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHB2_RAT
Primary accession number Q62730
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 58)
Name and origin of the protein
Protein name Estradiol 17-beta-dehydrogenase 2
Synonyms EC 1.1.1.62
Testosterone 17-beta-dehydrogenase
EC 1.1.1.63
17-beta-hydroxysteroid dehydrogenase 2
17-beta-HSD 2
Gene name
Name: Hsd17b2
Synonyms: Edh17b2
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Placenta;
DOI=10.1210/en.137.5.1572; PubMed=8612487 [NCBI, ExPASy, EBI, Israel, Japan]
Akinola L.A., Poutanen M., Vihko R.;
"Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes.";
Endocrinology 137:1572-1579(1996).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X91234; CAA62617.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_077367.1; -.
UniGene Rn.10515
3D structure databases
ModBase Q62730.
Organism-specific databases
RGD 621803; Hsd17b2.
Gene expression databases
ArrayExpress Q62730; -.
GermOnline ENSRNOG00000013982; Rattus norvegicus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004303; Molecular function: estradiol 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0050327; Molecular function: testosterone 17-beta-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006694; Biological process: steroid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS Q62730.
ProtoNet Q62730.
Genome annotation databases
Ensembl ENSRNOG00000013982; Rattus norvegicus. [Contig view]
GeneID 79243; -.
KEGG rno:79243; -.
Phylogenomic databases
HOVERGEN Q62730; -.
Other
NextBio 614690; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Lipid synthesis; Membrane; NAD; Oxidoreductase; Signal-anchor; Steroid biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   381  381     Estradiol 17-beta-dehydrogenase 2. PRO_0000054572
TRANSMEM   4    24  21     Signal-anchor for type II membrane protein (Potential). 
NP_BIND   83   112  30     NAD (By similarity). 
ACT_SITE   233   233        Proton acceptor (By similarity). 
BINDING   220   220        Substrate (By similarity). 
Sequence information
Length: 381 AA [This is the length of the unprocessed precursor] Molecular weight: 41967 Da [This is the MW of the unprocessed precursor] CRC64: 8E1D08DF345DE136 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNPFSSESAW LCLTATAVLG GMLLCKAWSS GQLRSQVVCL AGLWGGACLL SLSLLCSLFL 

        70         80         90        100        110        120 
LSVSCFFLLY VSSSDQDLLP VDQKAVLVTG ADSGFGHALA KHLDKLGFTV FAGVLDKEGP 

       130        140        150        160        170        180 
GAEELRKNCS ERLSVLQMDV TKPEQIKDVH SEVAEKIQDK GLWAVVNNAG VLHFPIDGEL 

       190        200        210        220        230        240 
IPMTVYRKCM AVNFFGAVEV TKVFLPLLRK SKGRLVNVSS MGAMIPFQMV AAYASTKAAI 

       250        260        270        280        290        300 
SMFSAVIRQE LAKWGVKVVT IHPGGFQTNI VGSQDSWDKM EKEILDHFSK EIQENYGQEY 

       310        320        330        340        350        360 
VHTQKLALPV MREMSNPDIT PVLRDIQHAI CAKNPSSFYC SGRMTYLWIC FAAYSPISLL 

       370        380 
DYILKNYFTP KLMPRALRTA S
Q62730 in FASTA format

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