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UniProtKB/Swiss-Prot entry Q62442


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VAMP1_MOUSE
Primary accession number Q62442
Secondary accession numbers Q6PFF3 Q810K6
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 82)
Name and origin of the protein
Protein name Vesicle-associated membrane protein 1
Synonyms VAMP-1
Synaptobrevin-1
Gene name
Name: Vamp1
Synonyms: Syb1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.;
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=BALB/c;
TISSUE=Brain;
Olken S.K., Doerre S., Corley R.B.;
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
TISSUE=Cerebellum, and Medulla oblongata;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6;
TISSUE=Retina;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 34-49; 50-58 AND 62-85, AND MASS SPECTROMETRY.
STRAIN=C57BL/6, and OF1;
TISSUE=Brain, and Hippocampus;
Lubec G., Kang S.U., Sunyer B., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1002/pmic.200401066; PubMed=15648052 [NCBI, ExPASy, EBI, Israel, Japan]
Vosseller K., Hansen K.C., Chalkley R.J., Trinidad J.C., Wells L., Hart G.W., Burlingame A.L.;
"Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol.";
Proteomics 5:388-398(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U61751; AAB03491.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF007167; AAB62930.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK018783; BAB31407.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK078156; BAC37151.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC049902; AAH49902.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057587; AAH57587.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00125990; -.
IPI00761439; -.
RefSeq NP_001074026.1; -.
NP_033522.1; -.
UniGene Mm.32321
3D structure databases
HSSP P19065; 1F83. [HSSP ENTRY / PDB]
SMR Q62442; 27-94.
ModBase Q62442.
PTM databases
PhosphoSite Q62442; -.
Organism-specific databases
MGI MGI:1313276; Vamp1.
Gene expression databases
ArrayExpress Q62442; -.
Bgee Q62442; -.
CleanEx MM_VAMP1; -.
GermOnline ENSMUSG00000030337; Mus musculus.
Ontologies
GO
GO:0030054; Cellular component: cell junction (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0030141; Cellular component: secretory granule (inferred from electronic annotation from UniProtKB-SubCell).
GO:0030672; Cellular component: synaptic vesicle membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0019717; Cellular component: synaptosome (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016192; Biological process: vesicle-mediated transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001388; Synaptobrevin.
IPR016444; Synaptobrevin_met/fun.
Graphical view of domain structure.
Pfam PF00957; Synaptobrevin; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF005409; Synaptobrevin_euk; 1.
PRINTS PR00219; SYNAPTOBREVN.
ProDom PD001229; Synaptobrevin; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00417; SYNAPTOBREVIN; 1.
PS50892; V_SNARE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q62442; -.
Genome annotation databases
Ensembl ENSMUSG00000030337; Mus musculus. [Contig view]
GeneID 22317; -.
KEGG mmu:22317; -.
Phylogenomic databases
HOVERGEN Q62442; -.
Other
NextBio 302523; -.
SOURCE Vamp1; Mus musculus.
ProtoNet Q62442.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell junction; Coiled coil; Cytoplasmic vesicle; Direct protein sequencing; Membrane; Phosphoprotein; Synapse; Synaptosome; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   118  118     Vesicle-associated membrane protein 1. PRO_0000206720
TOPO_DOM   1    96  96     Cytoplasmic (Potential). 
TRANSMEM   97   116  20     Anchor for type IV membrane protein (Potential). 
TOPO_DOM   117   118  2     Vesicular (Potential). 
DOMAIN   33    93  61     v-SNARE coiled-coil homology. 
MOD_RES   63    63        Phosphoserine. 
VAR_SEQ   114   118        IYFFT -> SKYR (in isoform 2). VSP_029186
Sequence information
Length: 118 AA [This is the length of the unprocessed precursor] Molecular weight: 12890 Da [This is the MW of the unprocessed precursor] CRC64: 31CB8701446A7FB0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV NVDKVLERDQ 

        70         80         90        100        110 
KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT 

Q62442 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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