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UniProtKB/Swiss-Prot entry Q60V67

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name JHD1_CAEBR
Primary accession number Q60V67
Secondary accession numbers None
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 23)
Name and origin of the protein
Protein name JmjC domain-containing histone demethylation protein 1
Synonyms EC 1.14.11.27
[Histone-H3]-lysine-36 demethylase 1
Gene name
Name: jhd-1
ORFNames: CBG19679
From
Caenorhabditis briggsae [TaxID: 6238] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AF16;
DOI=10.1371/journal.pbio.0000045; PubMed=14624247 [NCBI, ExPASy, EBI, Israel, Japan]
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H.;
"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics.";
PLoS Biol. 1:166-192(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CAAC01000101; CAE72500.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q60V67.
Organism-specific databases
WormBase WBGene00038854; CBG19679.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from UniProtKB-KW).
GO:0051864; Molecular function: histone demethylase activity (H3-K36 specific) (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (inferred from electronic annotation from UniProtKB-KW).
GO:0016568; Biological process: chromatin modification (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013129; TF_JmjC.
IPR003347; TF_JmjC_AAH.
Graphical view of domain structure.
Pfam PF02373; JmjC; 1.
Pfam graphical view of domain structure.
SMART SM00558; JmjC; 1.
SMART graphical view of domain structure.
PROSITE PS51184; JMJC; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q60V67.
ProtoNet Q60V67.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Chromatin regulator; Complete proteome; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Transcription; Transcription regulation.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1063  1063     JmjC domain-containing histone demethylation protein 1. PRO_0000226788
DOMAIN   86    266  181     JmjC. 
COMPBIAS   584    709  126     Glu-rich. 
COMPBIAS   655    727  73     Lys-rich. 
METAL   163    163        Iron; catalytic (By similarity). 
METAL   165    165        Iron; catalytic (By similarity). 
METAL   234    234        Iron; catalytic (By similarity). 
BINDING   160    160        Substrate (By similarity). 
BINDING   180    180        Substrate (By similarity). 
Sequence information
Length: 1063 AA [This is the length of the unprocessed precursor] Molecular weight: 121968 Da [This is the MW of the unprocessed precursor] CRC64: 1A904471269FDA24 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPEELTIEW YEENGLEKPI HFRCDPTRIG MKLPSPSTFT VDSVLELVGG NRMIEVVQVE 

        70         80         90        100        110        120 
DQGSVKMTLE EFVEFYKTPR DQRKNLYNVL SLEYSLTPLE DLVNSPALVR QIDWVGNIWP 

       130        140        150        160        170        180 
DALRQRWISF NGREKKSYFP HHTFPKVQNY CLMSVANCYT DFHIDFSGTS VWYHVLKGRK 

       190        200        210        220        230        240 
VFWLIPPTAT NFFIYQEFIK TVSDNAFFGR SVEACHVAVL EPGDTMLIPS GWIHAVYTPD 

       250        260        270        280        290        300 
DSLVFGGNFL HSLSCQTQLR VYQVENKLNI TRKFRLPYNE ELLFYVMADY VKKWTGREYV 

       310        320        330        340        350        360 
RPLLVEDAKL DYVGEKWKAA GGHLKKIRFE DYNVEVTSEM VKNEEESEKD EVKVIAMHAG 

       370        380        390        400        410        420 
SSNYDNAMIS KMSYTEATGL EEEAEDEDVK PETKKEAEER RDAEIDLLAA TNSLIFYRNS 

       430        440        450        460        470        480 
KHDFIRNKSV PDHKLPIGHE PPVYFNDEEV SRISPRLLEE LEALGAYIRR KNRVEVAEGI 

       490        500        510        520        530        540 
CHPASLINLF NTVLKKRRAE LTGKPFQFNQ IMPRRYTRAA IETGDYDFEP VRTIEDSRRA 

       550        560        570        580        590        600 
SQFKVEDFPD ELLESDEPDE TSRIHLPHQP SSGPLEYIPT PRGEIRENSL GFEPEYDEDM 

       610        620        630        640        650        660 
EEYDPAEQVV KEELEEEEEE EEGEEEEEEE YVAPVTRRSS TRGSASTKEE PQEEKEEKEA 

       670        680        690        700        710        720 
APKKEKKEKK VKKEKSSKPE KDTTEAKLKK EKKKKEMERR LRDSELEAEL RAAHGGKNAK 

       730        740        750        760        770        780 
SKKKPEKPAY VGGLPTAPIQ NDPVVSNPYN YDPRMEMMKL GTGQLKSAYR KTKANVELHI 

       790        800        810        820        830        840 
EKNLYKLEPK RDESESREPS MEHEDSPTTP HAPYDRYSHY HTENSHFQED QDSHRTPAKR 

       850        860        870        880        890        900 
SKYDNISVDT SESPHIPKKR SLEGRPSPYS VISPPHNRPK LSSPAMFSPS SEPRRSNDRR 

       910        920        930        940        950        960 
TSDPAVNAMK KGVYMPPMSR QDKMIAEAAS ASSSRHSSFS ERRPSFIPDL NSSRHSSTDT 

       970        980        990       1000       1010       1020 
PMYTPTAPAR SSWLPNTSNV TRHSLDDDSP IDVVSESPID VLNSPPFPRS ITPPPVSLSE 

      1030       1040       1050       1060 
LKSQSNGRKS NYSEDGKRAK IPAREAVAEL KTLIGKLKTL NEA
Q60V67 in FASTA format

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