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UniProtKB/Swiss-Prot entry Q59M70

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MCR1_CANAL
Primary accession number Q59M70
Secondary accession numbers None
Integrated into Swiss-Prot on April 29, 2008
Sequence was last modified on April 26, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 31)
Name and origin of the protein
Protein name NADH-cytochrome b5 reductase 2
Synonyms EC 1.6.2.2
Mitochondrial cytochrome b reductase
Gene name
Name: MCR1
ORFNames: CaO19.3507, CaO19.11001
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314;
DOI=10.1073/pnas.0401648101; PubMed=15123810 [NCBI, ExPASy, EBI, Israel, Japan]
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AACQ01000234; EAK91585.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACQ01000233; EAK91601.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_710831.1; -.
XP_710845.1; -.
3D structure databases
ModBase Q59M70.
Organism-specific databases
CGD CAL0005780; MCR1.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005741; Cellular component: mitochondrial outer membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0004128; Molecular function: cytochrome-b5 reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001834; Cyt_B5_reductase.
IPR001709; FPN_cyt_redctse.
IPR008333; OxRdtase_FAD-bd.
IPR001433; OxRdtase_FAD/NAD_bd.
Graphical view of domain structure.
Pfam PF00970; FAD_binding_6; 1.
PF00175; NAD_binding_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00406; CYTB5RDTASE.
PR00371; FPNCR.
PROSITE PS51384; FAD_FR; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q59M70.
Genome annotation databases
GeneID 3647561; -.
3647575; -.
KEGG cal:CaO19.11001; -.
cal:CaO19.3507; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; NAD; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   301  301     NADH-cytochrome b5 reductase 2. PRO_0000330176
TRANSMEM   14    30  17     Potential. 
DOMAIN   51   155  105     FAD-binding FR-type. 
NP_BIND   158   193  36     FAD (By similarity). 
Sequence information
Length: 301 AA [This is the length of the unprocessed precursor] Molecular weight: 33460 Da [This is the MW of the unprocessed precursor] CRC64: 7F16134D770DBDFB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLTHHLSKLA TPKFLVPFAG ATALSIGLAL QYSTSNNYIA NETGKTFTDS NEWVDLKLSK 

        70         80         90        100        110        120 
SIDLTHNTKH LVFKLKDEND VSGLITASCL LTKFVTPKGN NVIRPYTPVS DVNQSGEIDF 

       130        140        150        160        170        180 
VIKKYDGGKM SSHIFDLKEG ETLSFKGPIV KWKWEPNQFK SIALIGGGTG ITPLYQLLHQ 

       190        200        210        220        230        240 
ITSNPKDNTK VNLIYGNLTP EDILLKKEID AIASKHKDQV KVHYFVDKAD EKKWEGQIGF 

       250        260        270        280        290        300 
ITKEFLQKEL EKPGSDFKVF VCGPPGLYKA ISGPKVSPTD QGELTGALKD LGFEKEHVFK 


F
Q59M70 in FASTA format

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