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UniProtKB/Swiss-Prot entry Q57QM2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GHRA_SALCH
Primary accession number Q57QM2
Secondary accession numbers None
Integrated into Swiss-Prot on September 2, 2008
Sequence was last modified on May 10, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 21)
Name and origin of the protein
Protein name Glyoxylate/hydroxypyruvate reductase A
Synonyms EC 1.1.1.79
EC 1.1.1.81
2-ketoacid reductase
Gene name
Name: ghrA
OrderedLocusNames: SCH_1083
From
Salmonella choleraesuis [TaxID: 591] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC-B67;
DOI=10.1093/nar/gki297; PubMed=15781495 [NCBI, ExPASy, EBI, Israel, Japan]
Chiu C.-H., Tang P., Chu C., Hu S., Bao Q., Yu J., Chou Y.-Y., Wang H.-S., Lee Y.-S.;
"The genome sequence of Salmonella enterica serovar Choleraesuis, a highly invasive and resistant zoonotic pathogen.";
Nucleic Acids Res. 33:1690-1698(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE017220; AAX64989.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_216070.1; -.
3D structure databases
ModBase Q57QM2.
Enzyme and pathway databases
BioCyc SENT321314:SCH_1083-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0030267; Molecular function: glyoxylate reductase (NADP) activity (inferred from electronic annotation from HAMAP).
GO:0016618; Molecular function: hydroxypyruvate reductase activity (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01666; -; 1.
PBIL [Tree]
InterPro IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; FALSE_NEG.
PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
PS00671; D_2_HYDROXYACID_DH_3; FALSE_NEG.
ProtoNet Q57QM2.
Genome annotation databases
GeneID 3333535; -.
GenomeReviews AE017220_GR; SCH_1083.
KEGG sec:SC1083; -.
NMPDR fig|321314.4.peg.674; -.
Phylogenomic databases
HOGENOM Q57QM2; -.
Genome annotation databases
CMR Q57QM2; SCH_1083.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   312  312     Glyoxylate/hydroxypyruvate reductase A. PRO_0000348368
ACT_SITE   227   227        By similarity. 
ACT_SITE   275   275        Proton donor (By similarity). 
Sequence information
Length: 312 AA [This is the length of the unprocessed precursor] Molecular weight: 35064 Da [This is the MW of the unprocessed precursor] CRC64: A46D708D3F0D0C00 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEIIFYHPTF NAAWWVNALE KALPHARVRE WKVGDNNPAD YALVWQPPVE MLAGRRLKAV 

        70         80         90        100        110        120 
FVLGAGVDAI LSKLNAHPEM LDASIPLFRL EDTGMGLQMQ EYAVSQVLHW FRRFDDYQAL 

       130        140        150        160        170        180 
KNQALWKPLP EYTREEFSVG IMGAGVLGAK VAESLQAWGF PLRCWSRSRK SWPGVESYVG 

       190        200        210        220        230        240 
REELRAFLNQ TRVLINLLPN TTQTVGIINS ELLDQLPDGA YVLNLARGVH VQEADLLAAL 

       250        260        270        280        290        300 
DSGKLKGAML DVFSQEPLPQ ESPLWRHPRV AMTPHIAAVT RPAEAIDYIS RTITQLEKGE 

       310 
PVTGQVDRAR GY
Q57QM2 in FASTA format

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