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UniProtKB/Swiss-Prot entry Q54GJ7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HOT_DICDI
Primary accession number Q54GJ7
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 23)
Name and origin of the protein
Protein name Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial [Precursor]
Synonyms HOT
EC 1.1.99.24
Gene name
Name: adhfe1
ORFNames: DDB_G0290111
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000153; EAL62385.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_635889.1; -.
3D structure databases
ModBase Q54GJ7.
Organism-specific databases
dictyBase DDB0252839; adhfe1.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from sequence or structural similarity from UniProtKB).
GO:0047988; Molecular function: hydroxyacid-oxoacid transhydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from InterPro).
GO:0015993; Biological process: molecular hydrogen transport (inferred from sequence or structural similarity from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001670; Fe_AlcDHase.
Graphical view of domain structure.
Pfam PF00465; Fe-ADH; 1.
Pfam graphical view of domain structure.
PROSITE PS00913; ADH_IRON_1; FALSE_NEG.
PS00060; ADH_IRON_2; FALSE_NEG.
ProtoNet Q54GJ7.
Genome annotation databases
GeneID 3387462; -.
KEGG ddi:DDBDRAFT_0219524; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   547        Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial. PRO_0000323002
Sequence information
Length: 547 AA [This is the length of the unprocessed precursor] Molecular weight: 59743 Da [This is the MW of the unprocessed precursor] CRC64: B03F1DF8B3B4DFC4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTIIITKIAD KIIKSNRVKN TLQDIHIHSS NCGCHGSFKS NSVMNQTFSS FSSLTTEKNE 

        70         80         90        100        110        120 
QQQQQLFKQF SNSKPIPMGR KVELDTSKVI DSVYFGNTEN NNYRTNKGNT DYAFEASANN 

       130        140        150        160        170        180 
IRFGSGVTYE VGYDLLDMNC RNVIVFTDNN LLKLVDTDKE SAVAKCLYSL EKCGIKYTIY 

       190        200        210        220        230        240 
SDVSIEPTDT SFKDAISVMG KGRYDGVVAV GGGSVMDTAK AANLYNSYPP ADNDFLAYIN 

       250        260        270        280        290        300 
PPIGKGLLVP GPLKRPLIAI PTTCGTASET TGVCILDIKL GDGLSAKTGI ASRHLKPILG 

       310        320        330        340        350        360 
LVDPDNLLTL PSNVAISSGF DQLCHALESF TAIPFNQRSP RPLAPNQRPS YQGANPVSDV 

       370        380        390        400        410        420 
WSLRSLEMLC KNIHRFVLNP NDDYARSQMM LAASYAGLGF GNSGVHACHG MSYSISSMVK 

       430        440        450        460        470        480 
DYKPEGYYGL KKNLIPHGQS VILSAPAVFK FTAPSNPERH LLLAKIMGAD ISNASESDAG 

       490        500        510        520        530        540 
VLLSNQIVKL MKLLNVPNGL QALGYKESDI DSLVKGTLPQ HRVTKLMPKQ ATYDDLYKLF 


KDSMTIY 

Q54GJ7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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