[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-752 (ISOFORM 1). TISSUE=Chondrocyte; DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan] Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; "Complete sequencing and characterization of 21,243 full-length human cDNAs."; Nat. Genet. 36:40-45(2004).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 221-511 (ISOFORM 3), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 762-923 (ISOFORM 1). TISSUE=Cervix, and Uterus; The German cDNA consortium; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + NADP⁺ + H₂O = tetrahydrofolate + CO₂ + NADPH.

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	Q3SY69-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q3SY69-2
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_030752, VSP_030753.

Name	3
Isoform ID	Q3SY69-3
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_030754, VSP_030755.

SIMILARITY: In the N-terminal section; belongs to the GART family.
SIMILARITY: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
SIMILARITY: Contains 1 acyl carrier domain.
SEQUENCE CAUTION:
- Sequence=AAI03936.1; Type=Erroneous translation; Note=Wrong choice of CDS

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC103934; AAI03935.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC103935; AAI03936.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK095827; BAC04634.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CR627287; CAH10368.1; ALT_TERM; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CR749561; CAH18358.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001029345.1; -.

UniGene

Hs.42572

3D structure databases

SMR

Q3SY69; 426-923.

ModBase

Q3SY69.

Organism-specific databases

HGNC:26777; ALDH1L2.

PA134928545; -.

Gene expression databases

ArrayExpress

Q3SY69; -.

CleanEx

HS_ALDH1L2; -.

Ontologies

GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011407; 10_FTHF_DHase.
IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005793; Formyl_trans_C.
IPR002376; Formyl_transf_N.
IPR001555; GART_AS.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
G3DSA:3.10.25.10; Formyl_trans_C; 1.
G3DSA:3.40.50.170; Formyl_transf_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
PF02911; Formyl_trans_C; 1.
PF00551; Formyl_trans_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036489; 10-FTHFDH; 1.

PROSITE

PS50075; ACP_DOMAIN; 1.
PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PS00373; GART; 1.
PS00012; PHOSPHOPANTETHEINE; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSG00000136010; Homo sapiens. [Contig view]

GeneID

160428; -.

KEGG

hsa:160428; -.

Phylogenomic databases

HOGENOM

Q3SY69; -.

HOVERGEN

Q3SY69; -.

Other

NextBio

87968; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 923`	`923`	`Probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2.`	`PRO_0000316001`
`DOMAIN`	`344 413`	`70`	`Acyl carrier.`
`REGION`	`23 225`	`203`	`GART.`
`REGION`	`438 923`	`486`	`Aldehyde dehydrogenase.`
`ACT_SITE`	`128 128`		`Proton donor (By similarity).`
`ACT_SITE`	`694 694`		`By similarity.`
`ACT_SITE`	`728 728`		`By similarity.`
`BINDING`	`375 375`		`Phosphopantetheine (covalent) (By similarity).`
`SITE`	`164 164`	`1`	`Essential for catalytic activity (By similarity).`
`VAR_SEQ`	`199 203`		`VEAVQ -> KLSNS (in isoform 2).`	`VSP_030752`
`VAR_SEQ`	`204 923`		`Missing (in isoform 2).`	`VSP_030753`
`VAR_SEQ`	`512 516`		`RLADL -> SMRMN (in isoform 3).`	`VSP_030754`
`VAR_SEQ`	`517 923`		`Missing (in isoform 3).`	`VSP_030755`
`CONFLICT`	`712 712`		`A -> T (in Ref. 1; AAI03935).`

Sequence information

Length: 923 AA [This is the length of the unprocessed precursor]

Molecular weight: 101746 Da [This is the MW of the unprocessed precursor]

CRC64: C5DD74506F08AAFE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLRRGSQALR RFSTGRVYFK NKLKLALIGQ SLFGQEVYSH LRKEGHRVVG VFTVPDKDGK 

        70         80         90        100        110        120 
ADPLALAAEK DGTPVFKLPK WRVKGKTIKE VAEAYRSVGA ELNVLPFCTQ FIPMDIIDSP 

       130        140        150        160        170        180 
KHGSIIYHPS ILPRHRGASA INWTLIMGDK KAGFSVFWAD DGLDTGPILL QRSCDVEPND 

       190        200        210        220        230        240 
TVDALYNRFL FPEGIKAMVE AVQLIADGKA PRIPQPEEGA TYEGIQKKEN AEISWDQSAE 

       250        260        270        280        290        300 
VLHNWIRGHD KVPGAWTEIN GQMVTFYGST LLNSSVPPGE PLEIKGAKKP GLVTKNGLVL 

       310        320        330        340        350        360 
FGNDGKALTV RNLQFEDGKM IPASQYFSTG ETSVVELTAE EVKVAETIKV IWAGILSNVP 

       370        380        390        400        410        420 
IIEDSTDFFK SGASSMDVAR LVEEIRQKCG GLQLQNEDVY MATKFEGFIQ KVVRKLRGED 

       430        440        450        460        470        480 
QEVELVVDYI SKEVNEIMVK MPYQCFINGQ FTDADDGKTY DTINPTDGST ICKVSYASLA 

       490        500        510        520        530        540 
DVDKAVAAAK DAFENGEWGR MNARERGRLM YRLADLLEEN QEELATIEAL DSGAVYTLAL 

       550        560        570        580        590        600 
KTHIGMSVQT FRYFAGWCDK IQGSTIPINQ ARPNRNLTFT KKEPLGVCAI IIPWNYPLMM 

       610        620        630        640        650        660 
LAWKSAACLA AGNTLVLKPA QVTPLTALKF AELSVKAGFP KGVINIIPGS GGIAGQRLSE 

       670        680        690        700        710        720 
HPDIRKLGFT GSTPIGKQIM KSCAVSNLKK VSLELGGKSP LIIFNDCELD KAVRMGMGAV 

       730        740        750        760        770        780 
FFNKGENCIA AGRLFVEESI HDEFVTRVVE EIKKMKIGDP LDRSTDHGPQ NHKAHLEKLL 

       790        800        810        820        830        840 
QYCETGVKEG ATLVYGGRQV QRPGFFMEPT VFTDVEDYMY LAKEESFGPI MVISKFQNGD 

       850        860        870        880        890        900 
IDGVLQRANS TEYGLASGVF TRDINKAMYV SEKLEAGTVF INTYNKTDVA APFGGVKQSG 

       910        920 
FGKDLGEEAL NEYLKTKTVT LEY

Q3SY69 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools