NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
"Complete sequence of Pseudomonas fluorescens PfO-1.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000094; ABA74887.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_348878.1; -.

3D structure databases

ModBase

Q3KBG7.

Enzyme and pathway databases

BioCyc

PFLU205922:PFL_3149-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGR00594; polc; 1.

Genome annotation databases

GeneID

3712874; -.

GenomeReviews

CP000094_GR; PflO1_3149.

KEGG

pfo:PflO1_3149; -.

Phylogenomic databases

HOGENOM

Q3KBG7; -.

Genome annotation databases

CMR

Q3KBG7; Pfl01_3149.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1025`	`1025`		`Error-prone DNA polymerase.`	`PRO_1000070594`

Sequence information

Length: 1025 AA [This is the length of the unprocessed precursor]

Molecular weight: 115238 Da [This is the MW of the unprocessed precursor]

CRC64: B1C2F0E4DB44A93F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNQGYAELHC LSNFSFQRGA SSALELFQRA KKHGYQALAI TDECTLAGIV RAWQAAKSVE 

        70         80         90        100        110        120 
LPLIIGSEIR IENGPKLVLL VENIEGYQAL CGLITQARRR TQKGQYQILR EDFSEPLPGL 

       130        140        150        160        170        180 
LVLWVPEAVD EVEEGRWLKQ TFGERLWLAV QLHRGQNDQQ RLAALLSLAD ELQIPAVASG 

       190        200        210        220        230        240 
DVHMHARGRR ALQDTMTAIR HHVPVAEAGL RLHPNGERHL RSLDVLRELY PQTLLDESLK 

       250        260        270        280        290        300 
LARRCTFDLG ELRYQYPKEL VPEEHSASSW LRHLTEQGIA WRWPKGAQPK VLKQIDDELE 

       310        320        330        340        350        360 
LIAELGYESY FLTVHDVVRF AREQKILCQG RGSAANSAVC FALGITEIDP DRTTLLFERF 

       370        380        390        400        410        420 
MSRERNEPPD IDVDFEHERR EEVLQYVFRR YGRRRAALTA VVSTYHASGA IRDVAKALGL 

       430        440        450        460        470        480 
PPDQINALAD CCGHWSDETP PVERLREGGF DPESPLLHRV LSLTGQLIGF PRHLSQHPGG 

       490        500        510        520        530        540 
FVISEQPLDT LVPVENAAMA DRTIIQWDKD DLDAVGLLKV DILALGMLSA IRRCFDLLRR 

       550        560        570        580        590        600 
HRHQDLSLAT IPPEDRPTYD MISRADTIGV FQIESRAQMS MLPRLRPQTF YDLVIEVAIV 

       610        620        630        640        650        660 
RPGPIQGGMV HPYLRRRNKE EEETYPSPEL EVVLKRTLGV PLFQEQVMQI AIVAADYSPG 

       670        680        690        700        710        720 
EADQLRRSMA AWKRHGGLEP HKERLAAGMK KNGYSPEFAA QIFEQIKGFG SYGFPESHAA 

       730        740        750        760        770        780 
SFALLTYASC WLKCHEPAAF ACALINSWPM GFYSPDQILQ DARRHHLQIR PVDVRASDWD 

       790        800        810        820        830        840 
CSLEPIAGEQ PAIRMGLRMI KGFREEDARS IEKARARGAF ADVADLGERA GLDSRAQALL 

       850        860        870        880        890        900 
ADAGALRGLA GHRHRARWEV AGVQKQLGLF AGLPSQEEPD VLLPTPSVSE DLFTDYATLG 

       910        920        930        940        950        960 
TTLGPHPLTL LRNELRARRC RSSRDLLEVE HGRPVSVAGL VTGRQRPGTA SGVTFVTLED 

       970        980        990       1000       1010       1020 
EFGNVNVVVW RDLAERQRQV LVGSQLLKVD GRWEREGEVR HLIAGRLSDL TPLLNGIRVQ 


SRDFH

Q3KBG7 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools