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UniProtKB/Swiss-Prot entry Q3JMZ6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BURP1
Primary accession number Q3JMZ6
Secondary accession numbers None
Integrated into Swiss-Prot on April 4, 2006
Sequence was last modified on November 8, 2005 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 21)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BURPS1710b_3693
From
Burkholderia pseudomallei (strain 1710b) [TaxID: 320372] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Woods D.E., Nierman W.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000124; ABA50269.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_335057.1; -.
3D structure databases
ModBase Q3JMZ6.
Enzyme and pathway databases
BioCyc BPSE320372:BURPS1710B_A3991-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q3JMZ6.
ProtoNet Q3JMZ6.
Genome annotation databases
GeneID 3691601; -.
GenomeReviews CP000124_GR; BURPS1710b_3693.
KEGG bpm:BURPS1710b_3693; -.
TIGR BURPS1710b_3693; -.
Phylogenomic databases
HOGENOM Q3JMZ6; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   445  445     Histidinol dehydrogenase. PRO_0000229852
ACT_SITE   335   335        Proton acceptor (By similarity). 
ACT_SITE   336   336        Proton acceptor (By similarity). 
METAL   267   267        Zinc (By similarity). 
METAL   270   270        Zinc (By similarity). 
METAL   369   369        Zinc (By similarity). 
METAL   428   428        Zinc (By similarity). 
BINDING   138   138        NAD (By similarity). 
BINDING   199   199        NAD (By similarity). 
BINDING   222   222        NAD (By similarity). 
BINDING   245   245        Substrate (By similarity). 
BINDING   267   267        Substrate (By similarity). 
BINDING   270   270        Substrate (By similarity). 
BINDING   336   336        Substrate (By similarity). 
BINDING   369   369        Substrate (By similarity). 
BINDING   423   423        Substrate (By similarity). 
BINDING   428   428        Substrate (By similarity). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 47363 Da [This is the MW of the unprocessed precursor] CRC64: 3E9BD760F554A7E8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAIKIRKLDS TSEGFAAELR AVLAFEASED DAIERAVAQI LADVKARGDA AVLDYTNRFD 

        70         80         90        100        110        120 
RLNAASVAAL ELPQSELEAA LEGLEPKRRA ALEAAAARVR GYHEKQKIEC GSHSWQYTEA 

       130        140        150        160        170        180 
DGTVLGQKVT PLDRVGLYVP GGKAAYPSSV LMNAIPARVA GVGEIVMVVP TPDGLKNDLV 

       190        200        210        220        230        240 
LAAALLGGVD RVFTIGGAQA VAALAYGTQT VPAVDKICGP GNAYVASAKR RVFGTVGIDM 

       250        260        270        280        290        300 
IAGPSEILVL CDGTTDPSWV AMDLFSQAEH DELAQSILLC PDEAFIERVE KAIGELLPTM 

       310        320        330        340        350        360 
PRQDVIRASL EGRGALVKVR DMAEACRIAN DIAPEHLEIS ALEPHQWGKQ IRHAGAIFLG 

       370        380        390        400        410        420 
RYTSESLGDY CAGPNHVLPT SRTARFSSPL GVYDFFKRSS LIEVSAEGAH TLGEIASELA 

       430        440 
YGEGLQAHAK SAEYRMKGAG DRQKG
Q3JMZ6 in FASTA format

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