NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.3952905; PubMed=16169924 [NCBI, ExPASy, EBI, Israel, Japan]
Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.;
"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.";
Genome Res. 15:1336-1343(2005).

Comments

FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR936257; CAI48329.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_325898.1; -.

3D structure databases

ModBase

Q3IU54.

Enzyme and pathway databases

BioCyc

NPHA348780:NP0476A-MON; -.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016275; PolC_DP2; 1.

TIGR00354; polC; 1.

Genome annotation databases

GeneID

3703041; -.

GenomeReviews

CR936257_GR; NP0476A.

KEGG

nph:NP0476A; -.

NMPDR

fig|348780.3.peg.292; -.

Phylogenomic databases

HOGENOM

Q3IU54; -.

Genome annotation databases

CMR

Q3IU54; NP0476A.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1198`	`1198`		`DNA polymerase II large subunit.`	`PRO_0000294698`

Sequence information

Length: 1198 AA [This is the length of the unprocessed precursor]

Molecular weight: 132156 Da [This is the MW of the unprocessed precursor]

CRC64: 0F886B4A2B484FFA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MREDDEQYFR RLESDLDTAL SVAREARKRG GDPTEDIEIP IAKDMADRVE NILGIDGVAE 

        70         80         90        100        110        120 
RVREMEADPD LSREEAALEL AADFANDEVG DYETRAGKVE GAVRTAVALL TEGVVAAPIE 

       130        140        150        160        170        180 
GIDRVELLEN DDGTEFINIY YAGPIRSAGG TAQALSVLVA DYTRTLIGID EYKARNDETE 

       190        200        210        220        230        240 
RYAEELSLYD DETGLQYAPK DEETKFIAEH MPIMLDGEAT GDEEVSGFRD LERVDTNSAR 

       250        260        270        280        290        300 
GGMCLVLGEG IAQKAPKIQR YTSQLDEVDW PWLQDLIDGT YKTGEDTDEA DADSDDGTDE 

       310        320        330        340        350        360 
DAADDSDIDD SSAGDEEADA PSGPPRPDPQ KKFLRDLIAG RPVFGHPSEP GGFRLRYGRA 

       370        380        390        400        410        420 
RNHGFATAGV HPAAMHLIDD FLATGTQIKT ERPGKAAGVV PVDTIEGPTV KLANGDVRRV 

       430        440        450        460        470        480 
DDPEEALEIR NGVEAILDLG EYLVNYGEFV ENNHPLSPAA YAPEWWTQDL AAAGADVQAL 

       490        500        510        520        530        540 
ADSPRVDLEH PSAEQALEWA ERYDAPLHPE YTYLWHDLDV ERFEALAAAA SEGHWAETDG 

       550        560        570        580        590        600 
AQQTRPPDGA AESTLVVPRS EPVREALEVL LVEHTQGEET LTVPDAEPLV RSLGLTEGLE 

       610        620        630        640        650        660 
RTWDELSTAA RSYDDGDNAV RAVNEVAPFE VRERAPTRIG CRMGRPEKSE KRDLSPAVHT 

       670        680        690        700        710        720 
LFPIGEAGGS QRDIAEAATH AESMQDTPGE VEVQVGRRQC PACDTETFRA RCPDCESVTD 

       730        740        750        760        770        780 
PRYVCYDCNI DVDPDESGRA ICPNCEREAD AVQNRTVNVH EEYRSALSNV GERENAFDVL 

       790        800        810        820        830        840 
KGVKGLSSEH KVPEPIEKGV LRAKHGVSAF KDGTVRYDMT DLPVTSVRAA ELDVTADQLR 

       850        860        870        880        890        900 
SLGYETDIHG EPLTHEDQLV ELRVQDVVLS NGAAEHMLRT ADFVDDLLEQ YYGLEPFYDA 

       910        920        930        940        950        960 
EDRDDIVGEL VFGMAPHTSA AVVGRVIGFT SAAVGYAHPY FHAAKRRNCD GDEDCVMLLL 

       970        980        990       1000       1010       1020 
DGLLNFSKTF LPDQRGGRMD APLVMSSRID PAEIDDEAHN MDIVSSYPRA FFEATREMAD 

      1030       1040       1050       1060       1070       1080 
PGEVESLIQL GEDTLGTADE YRGFEHTHDT VDLAAGPDLS AYKTLGDMME KMDAQLELSR 

      1090       1100       1110       1120       1130       1140 
KLRSVDETDV AERVIEYHFL PDIIGNLRAF SRQETRCLDC GEKYRRVPLT GDCRECGGRV 

      1150       1160       1170       1180       1190 
NLTVHQGSVN KYIDTAIQVA EEYGCREYTK QRLRILDRAV ESIFEDDTNK QSGIADFM

Q3IU54 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools