[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Prostate; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[2]	ENZYME ACTIVITY, PATHWAY, AND SUBCELLULAR LOCATION. PubMed=666752 [NCBI, ExPASy, EBI, Israel, Japan] Elder G.H., Evans J.O.; "Evidence that the coproporphyrinogen oxidase activity of rat liver is situated in the intermembrane space of mitochondria."; Biochem. J. 172:345-347(1978).

Comments

CATALYTIC ACTIVITY: Coproporphyrinogen-III + O₂ + 2 H⁺ = protoporphyrinogen-IX + 2 CO₂ + 2 H₂O.
PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1 .
SUBCELLULAR LOCATION: Mitochondrion intermembrane space.
SIMILARITY: Belongs to the aerobic coproporphyrinogen III oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC107664; AAI07665.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001032172.1; -.

UniGene

Rn.19581

3D structure databases

SMR

Q3B7D0; 110-442.

ModBase

Q3B7D0.

Organism-specific databases

RGD

1311817; Cpox.

Gene expression databases

ArrayExpress

Q3B7D0; -.

Ontologies

GO:0005758;	Cellular component: mitochondrial intermembrane space (inferred from electronic annotation from UniProtKB-SubCell).
GO:0006783;	Biological process: heme biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001260; Coprogen_oxidas.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.1500.10; Coprogen_oxidas; 1.

PANTHER

PTHR10755; Coprogen_oxidas; 1.

Pfam

PF01218; Coprogen_oxidas; 1.
Pfam graphical view of domain structure.

PRINTS

PR00073; COPRGNOXDASE.

PROSITE

PS01021; COPROGEN_OXIDASE; 1.

Genome annotation databases

Ensembl

ENSRNOG00000001654; Rattus norvegicus. [Contig view]

GeneID

304024; -.

KEGG

rno:304024; -.

NMPDR

fig|10116.3.peg.6954; -.

Phylogenomic databases

HOVERGEN

Q3B7D0; -.

Other

NextBio

652479; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Heme biosynthesis; Mitochondrion; Oxidoreductase; Phosphoprotein; Porphyrin biosynthesis; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 98`	`98`	`Mitochondrion (By similarity).`
`CHAIN`	`99 443`	`345`	`Coproporphyrinogen III oxidase, mitochondrial.`	`PRO_0000293624`
`MOD_RES`	`99 99`		`Phosphoserine (By similarity).`
`MOD_RES`	`360 360`		`N6-acetyllysine (By similarity).`

Sequence information

Length: 443 AA [This is the length of the unprocessed precursor]

Molecular weight: 49278 Da [This is the MW of the unprocessed precursor]

CRC64: C599A521060628A4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALRLGQLGS GPWWRAVRGD YAQLRAPSPR SASACVCRLP GTAGTQPRRG LGHGSSAGGG 

        70         80         90        100        110        120 
SRLGTGLAAA LAGMAGLAAA VLGHVQRAEM VPKSSGARSP SPGRLEEDGD ELARRCSTFM 

       130        140        150        160        170        180 
SSPVTELREL GRRPDDMKTK MELMIMETQA QVCRALAQVD GVADFSVDRW ERKEGGGGIT 

       190        200        210        220        230        240 
CVLQDGRVFE KAGVNISVVH GNLSEEAANQ MRSRGKALKK KDGKLPFTAM GISSVIHPKN 

       250        260        270        280        290        300 
PYAPTMHFNY RYFEVEEADG KMHWWFGGGC DLTPTYLNRE DAVHFHRTLK EACDQHGPDI 

       310        320        330        340        350        360 
YPKFKKWCDD YFFIAHRGER RGIGGIFFDD LDSPSKEEAF RFVKTCAEAV VPSYVPIVKK 

       370        380        390        400        410        420 
HCDDSYTPQD KLWQQLRRGR YVEFNLVYDR GTKFGLFTPG SRIESILMSL PLTARWEYMH 

       430        440 
SPPENSKEAE ILEVLRHPKD WVH

Q3B7D0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools