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UniProtKB/Swiss-Prot entry Q34388

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_DROSI
Primary accession number Q34388
Secondary accession numbers Q34390 Q34393 Q36710
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on August 1, 1999 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 58)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1 [Fragments]
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: mt:CoI
Synonyms: CoI
From
Drosophila simulans (Fruit fly) [TaxID: 7240] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-102.
STRAIN=Nairobi;
PubMed=2832697 [NCBI, ExPASy, EBI, Israel, Japan]
Satta Y., Ishiwa H., Chigusa S.I.;
"Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species.";
Mol. Biol. Evol. 4:638-650(1987).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-499, AND VARIANTS.
STRAIN=Hawaii, and Sl3;
PubMed=2124697 [NCBI, ExPASy, EBI, Israel, Japan]
Satta Y., Takahata N.;
"Evolution of Drosophila mitochondrial DNA and the history of the melanogaster subgroup.";
Proc. Natl. Acad. Sci. U.S.A. 87:9558-9562(1990).
[3]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-511.
PubMed=8365657 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko M., Satta Y., Matsuura E.T., Chigusa S.I.;
"Evolution of the mitochondrial ATPase 6 gene in Drosophila: unusually high level of polymorphism in D. melanogaster.";
Genet. Res. 61:195-204(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M18072; AAA65482.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M57909; AAB02284.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
M57911; AAA66247.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S64977; AAD13955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00396; 2OCC. [HSSP ENTRY / PDB]
SMR Q34388; 4-511.
ModBase Q34388.
Organism-specific databases
FlyBase FBgn0012877; Dsim\mt:CoI.
Ontologies
GO
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q34388.
ProtoNet Q34388.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Polymorphism; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   511  511     Cytochrome c oxidase subunit 1. PRO_0000183328
TRANSMEM   16    36  21     Potential. 
TRANSMEM   55    75  21     Potential. 
TRANSMEM   101   121  21     Potential. 
TRANSMEM   144   164  21     Potential. 
TRANSMEM   182   202  21     Potential. 
TRANSMEM   233   253  21     Potential. 
TRANSMEM   267   287  21     Potential. 
TRANSMEM   304   324  21     Potential. 
TRANSMEM   337   357  21     Potential. 
TRANSMEM   379   399  21     Potential. 
TRANSMEM   413   433  21     Potential. 
TRANSMEM   451   471  21     Potential. 
METAL   60    60        Iron (heme A axial ligand) (Probable). 
METAL   239   239        Copper B (Probable). 
METAL   243   243        Copper B (Probable). 
METAL   289   289        Copper B (Probable). 
METAL   290   290        Copper B (Probable). 
METAL   375   375        Iron (heme A3 axial ligand) (Probable). 
METAL   377   377        Iron (heme A axial ligand) (Probable). 
CROSSLNK   239   243        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
VARIANT   451   451  1     V -> I (in strain: Hawaii). 
VARIANT   469   469  1     Y -> F (in strain: Hawaii). 
NON_CONS   499   500         
Sequence information
Length: 511 AA [This is the length of the partial sequence of the unprocessed precursor] Molecular weight: 56435 Da [This is the MW of the partial sequence of the unprocessed precursor] CRC64: D7573FCA465CEE8B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPRQWLFSTN HKDIGTLYFI FGAWAGMVGT SLSILIRAEL GHPGALIGDD QIYNVIVTAH 

        70         80         90        100        110        120 
AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS FWLLPPALSL LLVSSMVENG 

       130        140        150        160        170        180 
AGTGWTVYPP LSAGIAHGGA SVDLAIFSLH LAGISSILGA VNFITTVINM RSTGISLDRM 

       190        200        210        220        230        240 
PLFVWSVVIT ALLLLLSLPV LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP 

       250        260        270        280        290        300 
EVYILILPGF GMISHIISQE SGKKETFGSL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT 

       310        320        330        340        350        360 
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LSYSPAILWA LGFVFLFTVG GLTGVVLANS 

       370        380        390        400        410        420 
SVDIILHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLFT GLTLNNKWLK SQFIIMFIGV 

       430        440        450        460        470        480 
NLTFFPQHFL GLAGMPRRYS DYPDAYTTWN VVSTIGSTIS LLGILFFFYI IWESLVSQRQ 

       490        500        510 
VIYPIQLNSS IEWYQNTPPE HSYSELPLLT N
Q34388 in FASTA format

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