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UniProtKB/Swiss-Prot entry Q2T4T8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH2_BURTA
Primary accession number Q2T4T8
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on January 24, 2006 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 24)
Name and origin of the protein
Protein name Malate dehydrogenase 2
Synonym EC 1.1.1.37
Gene name
Name: mdh2
OrderedLocusNames: BTH_II1617
From
Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 106301) [TaxID: 271848] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A., Lathigra R., White O., Ketchum K.A., Palmer N., Dodson R., Hickey E.K., Gwinn M.L., Dougherty B., Fleischmann R.D., Richardson D.L., Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M., van-Vugt R., Adams M.D., Gocayne J.D., Weidman J., Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C., Garland S., Fujii C., Cotton M.D., Horst K., Tomb J.-F., Roberts K., Hatch B., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000085; ABC35074.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_439811.1; -.
3D structure databases
ModBase Q2T4T8.
Enzyme and pathway databases
BioCyc BTHA271848:BTH_II1617-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
Genome annotation databases
GeneID 3844557; -.
GenomeReviews CP000085_GR; BTH_II1617.
KEGG bte:BTH_II1617; -.
TIGR BTH_II1617; -.
Phylogenomic databases
HOGENOM Q2T4T8; -.
Other
ProtoNet Q2T4T8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   329  329     Malate dehydrogenase 2. PRO_0000292370
NP_BIND   12    18  7     NAD (By similarity). 
NP_BIND   130   132  3     NAD (By similarity). 
ACT_SITE   188   188        Proton acceptor (By similarity). 
BINDING   93    93        Substrate (By similarity). 
BINDING   99    99        Substrate (By similarity). 
BINDING   106   106        NAD (By similarity). 
BINDING   113   113        NAD (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   163   163        Substrate (By similarity). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 36101 Da [This is the MW of the unprocessed precursor] CRC64: 7771577BC065D687 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNTEAKRIAV SGAAGQIAYS LLFRIAQGDL LGEDQPVILQ LLDLPQAYGA VQGVVMELQD 

        70         80         90        100        110        120 
CAFPLLKEIQ VATDPHAAFL NADYAFLVGS KPRTKGMERR DLLAENAAIF RTQGRALNEA 

       130        140        150        160        170        180 
ASRDVKVLVV GNPANTNASI LRRFAPDLPD DAISAMIRLD HNRAVSMLAQ RCNVDVDSIA 

       190        200        210        220        230        240 
DMVVWGNHSP TMFPDYRHAR IGRRLVKDLI NDENWYRESF IPKVAQRGTA IIEARGASSA 

       250        260        270        280        290        300 
ASAANAAIDQ MRDWIFGSDG RWVSMSVPSD GSYGIAPGLM FGVPVICDGG RYERVKDIGI 

       310        320 
DAFARQRIDL SVRELQEEAD VVNRLFADR
Q2T4T8 in FASTA format

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