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UniProtKB/Swiss-Prot entry Q15008


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PSMD6_HUMAN
Primary accession number Q15008
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 72)
Name and origin of the protein
Protein name 26S proteasome non-ATPase regulatory subunit 6
Synonyms 26S proteasome regulatory subunit S10
p42A
Proteasome regulatory particle subunit p44S10
Phosphonoformate immuno-associated protein 4
Breast cancer-associated protein SGA-113M
Gene name
Name: PSMD6
Synonyms: KIAA0107, PFAAP4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary cancer;
DOI=10.1038/sj.onc.1203462; PubMed=10723133 [NCBI, ExPASy, EBI, Israel, Japan]
Ren S., Smith M.J., Louro I.D., McKie-Bell P., Bani M.R., Wagner M., Zochodne B., Redden D.T., Grizzle W.E., Wang N.D., Smith D.I., Herbst R.A., Bardenheuer W., Opalka B., Schutte J., Trent J.M., Ben-David Y., Ruppert J.M.;
"The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma.";
Oncogene 19:1419-1427(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Liu Y., Cheng J., Lu Y.;
"Screening and cloning of a new immuno-associated gene regulated by phosphonoformate.";
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Petroziello J.M.;
"Breast cancer associated protein.";
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow;
DOI=10.1093/dnares/2.1.37; PubMed=7788527 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.";
DNA Res. 2:37-43(1995).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lymph, Ovary, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
DOI=10.1021/bi061994u; PubMed=17323924 [NCBI, ExPASy, EBI, Israel, Japan]
Wang X., Chen C.-F., Baker P.R., Chen P.-L., Kaiser P., Huang L.;
"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.";
Biochemistry 46:3553-3565(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF215935; AAF65540.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF530062; AAQ09946.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY568086; AAS68366.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D14663; BAA03497.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000630; AAH00630.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC000904; AAH00904.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC012369; AAH12369.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_055629.1; -.
UniGene Hs.152536
3D structure databases
ModBase Q15008.
Protein-protein interaction databases
DIP DIP:27590N; -.
IntAct Q15008; -.
Enzyme and pathway databases
Reactome REACT_11045; Signaling by Wnt.
REACT_152; Cell Cycle, Mitotic.
REACT_1538; Cell Cycle Checkpoints.
REACT_383; DNA Replication.
REACT_6185; HIV Infection.
REACT_6850; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_9035; APC/C:Cdh1-mediated degradation of Skp2.
Organism-specific databases
H-InvDB HIX0003420; -.
HGNC HGNC:9564; PSMD6.
GenAtlas PSMD6.
PharmGKB PA33910; -.
GeneCards Q15008.
HUGE KIAA0107.
Gene expression databases
ArrayExpress Q15008; -.
CleanEx HS_PSMD6; -.
GermOnline ENSG00000163636; Homo sapiens.
Ontologies
GO
GO:0000502; Cellular component: proteasome complex (non-traceable author statement from UniProtKB).
GO:0016887; Molecular function: ATPase activity (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0031145; Biological process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (inferred from experiment from Reactome).
GO:0006510; Biological process: ATP-dependent proteolysis (non-traceable author statement from UniProtKB).
GO:0051436; Biological process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
GO:0051437; Biological process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle (inferred from experiment from Reactome).
QuickGo view.
Family and domain databases
InterPro IPR000717; PCI.
Graphical view of domain structure.
Pfam PF01399; PCI; 1.
Pfam graphical view of domain structure.
SMART SM00088; PINT; 1.
SMART graphical view of domain structure.
BLOCKS Q15008.
Genome annotation databases
Ensembl ENSG00000163636; Homo sapiens. [Contig view]
GeneID 9861; -.
KEGG hsa:9861; -.
Phylogenomic databases
HOVERGEN Q15008; -.
Other
ProtoNet Q15008.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Proteasome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   389  388     26S proteasome non-ATPase regulatory subunit 6. PRO_0000173838
DOMAIN   191   358  168     PCI. 
Sequence information
Length: 389 AA [This is the length of the unprocessed precursor] Molecular weight: 45531 Da [This is the MW of the unprocessed precursor] CRC64: 8843E6684AE91ACD [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS 

        70         80         90        100        110        120 
LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA 

       130        140        150        160        170        180 
LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL 

       190        200        210        220        230        240 
KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV 

       250        260        270        280        290        300 
IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR 

       310        320        330        340        350        360 
IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD 

       370        380 
SKNWQYQETI KKGDLLLNRV QKLSRVINM 

Q15008 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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