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UniProtKB/Swiss-Prot entry Q08409

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AUS1_YEAST
Primary accession number Q08409
Secondary accession number O94147
Integrated into Swiss-Prot on August 31, 2004
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name ATP-dependent permease AUS1
Synonyms None
Gene name
Name: AUS1
OrderedLocusNames: YOR011W
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9169874 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
Nature 387:98-102(1997).
[2]
 FUNCTION.
DOI=10.1074/jbc.M204707200; PubMed=12077145 [NCBI, ExPASy, EBI, Israel, Japan]
Wilcox L.J., Balderes D.A., Wharton B., Tinkelenberg A.H., Rao G., Sturley S.L.;
"Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast.";
J. Biol. Chem. 277:32466-32472(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z74919; CAA99199.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z74920; CAA99202.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S66876; S66876.
RefSeq NP_014654.1; -.
3D structure databases
ModBase Q08409.
Protein-protein interaction databases
DIP DIP:994N; -.
IntAct Q08409; -.
Organism-specific databases
CYGD YOR011w; -.
SGD S000005537; AUS1.
Yeast-GFP YOR011W.
Gene expression databases
ArrayExpress Q08409; -.
GermOnline YOR011W; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from SGD).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0015918; Biological process: sterol transport (inferred from mutant phenotype from SGD).
QuickGo view.
Family and domain databases
InterPro IPR003593; AAA+_ATPase_core.
IPR013525; ABC_2_trans.
IPR003439; ABC_transporter-like.
IPR010929; PDR_CDR_ABC.
Graphical view of domain structure.
Pfam PF01061; ABC2_membrane; 2.
PF00005; ABC_tran; 2.
PF06422; PDR_CDR; 2.
Pfam graphical view of domain structure.
ProDom PD000006; ABC_transporter; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00382; AAA; 1.
SMART graphical view of domain structure.
PROSITE PS00211; ABC_TRANSPORTER_1; 1.
PS50893; ABC_TRANSPORTER_2; 2.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q08409.
Genome annotation databases
Ensembl YOR011W; Saccharomyces cerevisiae. [Contig view]
GeneID 854175; -.
GenomeReviews Y13140_GR; YOR011W.
KEGG sce:YOR011W; -.
NMPDR fig|4932.3.peg.5750; -.
Phylogenomic databases
HOGENOM Q08409; -.
Other
LinkHub Q08409; -.
ProtoNet Q08409.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Repeat; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1394  1394     ATP-dependent permease AUS1. PRO_0000093434
TOPO_DOM   1    388  388     Cytoplasmic (Potential). 
TRANSMEM   389    408  20     Potential. 
TRANSMEM   421    443  23     Potential. 
TRANSMEM   468    490  23     Potential. 
TRANSMEM   497    519  23     Potential. 
TRANSMEM   529    551  23     Potential. 
TRANSMEM   558    575  18     Potential. 
TRANSMEM   636    658  23     Potential. 
TOPO_DOM   659   1080  422     Cytoplasmic (Potential). 
TRANSMEM   1081   1103  23     Potential. 
TRANSMEM   1107   1129  23     Potential. 
TRANSMEM   1156   1178  23     Potential. 
TRANSMEM   1193   1215  23     Potential. 
TRANSMEM   1224   1246  23     Potential. 
TRANSMEM   1346   1368  23     Potential. 
TOPO_DOM   1369   1394  26     Cytoplasmic (Potential). 
DOMAIN   33    273  241     ABC transporter 1. 
DOMAIN   751    978  228     ABC transporter 2. 
NP_BIND   782    789  8     ATP (Potential). 
Sequence information
Length: 1394 AA [This is the length of the unprocessed precursor] Molecular weight: 157751 Da [This is the MW of the unprocessed precursor] CRC64: 357A35A0FCF0C93B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSISKYFTPV ADGSLTFNGA NIQFGADAQG ESKKSYDAED SMPNPANQLN DITFQAEAGE 

        70         80         90        100        110        120 
MVLVLGYPTS TLFKTLFHGK TSLSYSPPGS IKFKNNEFKS FSEKCPHQII YNNEQDVHFP 

       130        140        150        160        170        180 
FLTVEQTIDF ALSCKFDIPK GERDQIRNEL LREFGLSHVL KTIVGNDFFR GVSGGERKRI 

       190        200        210        220        230        240 
SIIETFIANG SVYLWDNSTK GLDSATALDF LEILRKMAKA TRSVNLVRIS QASDKIVDKF 

       250        260        270        280        290        300 
DKILMLSDSY QLFYGTVDEC LTYFRDTLGI EKDPNDCIIE YLTSILNFQF KNKNLGNLSN 

       310        320        330        340        350        360 
SSSASVLKTA TGEVTKYTYN SDFDLYDQWK HSSYYRNIKQ QIQGSSIDDS IKEVDPSDVS 

       370        380        390        400        410        420 
PIFNIPLKKQ LLFCTKRAFQ RSLGDKAYMT AQFISVVIQS LVIGSLFYEI PLTTIGSYSR 

       430        440        450        460        470        480 
GSLTFFSILF FTFLSLADMP IAFQRQPVVK KQSQLHFYTN WVETLSTTVF DYCFKLCLVI 

       490        500        510        520        530        540 
VFSIILYFLA HLQYKAARFF IFLLFLSFYN FCMVSLFALT TLVAPTISVA NLFAGILLLA 

       550        560        570        580        590        600 
IAMYASYVIY LKNMHPWFVW IAYLNPAMYA MEAILSNELY NLKLDCSETI VPRGPTYNDV 

       610        620        630        640        650        660 
PFSHKACAWQ GATLGNDYVR GRDYLKQGLS YTYHHVWRNF GIIIGFLVFF IACTLFASQY 

       670        680        690        700        710        720 
IKPYFNKDEI ERNNSRLTRW LPFLNKKRGT RSSARNDSKY VGIPKSHSVS SSSSSLSAVP 

       730        740        750        760        770        780 
YQISPSNKEM ALNDYNEQPI TETVETQKHI ISWKNINYTV GTKKLINNAS GFISSGLTAL 

       790        800        810        820        830        840 
MGESGAGKTT LLNVLSQRVE TGVVSGEILI DGHPLTDEDA FKRSIGFVQQ QDLHLDLLSV 

       850        860        870        880        890        900 
KESLEISCLL RGDGDRAYLD TVSNLLKLPS DILVADLNPT QRKLLSIGVE LVTKPSLLLF 

       910        920        930        940        950        960 
LDEPTSGLDA EAALTIVKFL KQLSLQGQAI FCTIHQPSKS VISHFDNIFL LKRGGECVFF 

       970        980        990       1000       1010       1020 
GPMDDACGYF MSHDNTLVYD KEHDNPADFV IDAVGNSNSS AGKDTAEEAL TLNKEAIDWS 

      1030       1040       1050       1060       1070       1080 
ALWESSVEKK LVKKETARLE DDARASGVDY TTSLWKQPSY LQQLALITRR QYICTKRDMT 

      1090       1100       1110       1120       1130       1140 
YVMAKYCLNG GAGLFIGFSF WHIKHNIIGL QDSIFFCFMA LCVSSPLINQ IQDKALKTKE 

      1150       1160       1170       1180       1190       1200 
VYVAREARSN TYHWTVLLLS QSIIELPLAL TSSTLFFVCA FFSCGFNNAG WSAGVFFLNY 

      1210       1220       1230       1240       1250       1260 
MLFAAYYSTL GLWLIYTAPN LQTAAVFVAF IYSFTASFCG VMQPYSLFPT FWKFMYRVSP 

      1270       1280       1290       1300       1310       1320 
YTYFVETFVS ILLHNWEIKC DMSEMVPGQP LTGQSCGQFM EAFIEEYGGY LHNKNTFTVC 

      1330       1340       1350       1360       1370       1380 
AYCTYTVGDD FLKNENMSYD HVWRNFGIEW AFVGFNFFAM FAGYYLTYVA RIWPKVFKII 

      1390 
TKVIPHRGKK PVQN
Q08409 in FASTA format

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