ID   ITR3_CYCPE              Reviewed;          29 AA.
AC   P83394; P83392;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   22-JUL-2008, entry version 41.
DE   RecName: Full=Trypsin inhibitor 3;
DE   AltName: Full=Trypsin inhibitor III;
DE   AltName: Full=CyPTI-III;
DE   Contains:
DE     RecName: Full=Trypsin inhibitor 1;
DE     AltName: Full=Trypsin inhibitor I;
DE     AltName: Full=CyPTI-I;
OS   Cyclanthera pedata (Achocha) (Caihua).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids I; Cucurbitales; Cucurbitaceae; Cyclanthera.
OX   NCBI_TaxID=198836;
RN   [1]
RP   PROTEIN SEQUENCE, AND REACTIVE SITE.
RC   TISSUE=Seed;
RX   PubMed=14515156;
RA   Polanowski A., Wilimowska-Pelc A., Kowalska J., Grybel J., Zelazko M.,
RA   Wilusz T.;
RT   "Non-conventional affinity chromatography of serine proteinases and
RT   their inhibitors.";
RL   Acta Biochim. Pol. 50:765-773(2003).
CC   -!- FUNCTION: Inhibits trypsin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin (By similarity).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I7 (squash-type
CC       serine protease inhibitor) family.
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DR   HSSP; P01074; 1CTI.
DR   InterPro; IPR000737; Prot_inh_squash.
DR   Pfam; PF00299; Squash; 1.
DR   PRINTS; PR00293; SQUASHINHBTR.
DR   ProDom; PD003401; Prot_inh_squash; 1.
DR   SMART; SM00286; PTI; 1.
DR   PROSITE; PS00286; SQUASH_INHIBITOR; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Knottin; Protease inhibitor; Secreted;
KW   Serine protease inhibitor.
FT   PEPTIDE       1     29       Trypsin inhibitor 3.
FT                                /FTId=PRO_0000033204.
FT   PEPTIDE       2     29       Trypsin inhibitor 1.
FT                                /FTId=PRO_0000033205.
FT   SITE          5      6       Reactive bond.
FT   DISULFID      3     20       By similarity.
FT   DISULFID     10     22       By similarity.
FT   DISULFID     16     28       By similarity.
SQ   SEQUENCE   29 AA;  3195 MW;  D5FEFF8A5FEDCC2F CRC64;
     RICPRILMEC KADSDCLAQC ICEESGFCG
//