NUCLEOTIDE SEQUENCE.
DOI=10.1073/pnas.93.6.2328; PubMed=8637872 [NCBI, ExPASy, EBI, Israel, Japan]
Burger G., Lang B.F., Reith M., Gray M.W.;
"Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes.";
Proc. Natl. Acad. Sci. U.S.A. 93:2328-2332(1996).

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

ModBase

P80477.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0051537;	Molecular function: 2 iron, 2 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051538;	Molecular function: 3 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051539;	Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
GO:0006099;	Biological process: tricarboxylic acid cycle (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Other

ProtoNet

P80477.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 239`	`239`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit.`	`PRO_0000158696`
`DOMAIN`	`24 99`	`76`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`142 172`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`63 63`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`68 68`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`71 71`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`83 83`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`152 152`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`155 155`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`158 158`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`162 162`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`209 209`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`215 215`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`219 219`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`167 167`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 239 AA [This is the length of the unprocessed precursor]

Molecular weight: 27301 Da [This is the MW of the unprocessed precursor]

CRC64: 5209A3754CAC3E20 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRPRNNNLNL KFIRIYRWTP SNQAEAKFSV HPIHTSNCGP MILDALIKIK DEQDSSLAFR 

        70         80         90        100        110        120 
RSCREGICGS CSMNIDGINT LACLKPIKTN ANIITIYPLP HMYIIKDLVP DLSNFFSQYK 

       130        140        150        160        170        180 
YIKPWLINNV PKKSEYLQSE KDRSELNGIY ECILCACCSA SCPSYWWNHD KYLGPAILLQ 

       190        200        210        220        230 
AYRWLADSRD TNAKERLKLL GGKSKLFKCH TIMNCSRTCP KSLNPGKAIA SIKHSINYS

P80477 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools