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[1]
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NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF CYS-258, AND 3D-STRUCTURE MODELING.
TISSUE=Placenta;
PubMed=7743998 [NCBI, ExPASy, EBI, Israel, Japan]
Faucheu C.,
Diu A.,
Chan A.W.E.,
Blanchet A.-M.,
Miossec C.,
Herve F.,
Collard-Dutilleul V.,
Gu Y.,
Aldape R.A.,
Lippke J.A.,
Rocher C.,
Su M.S.-S.,
Livingston D.J.,
Hercend T.,
Lalanne J.-L.;
"A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.";
EMBO J. 14:1914-1922(1995).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.270.26.15870; PubMed=7797592 [NCBI, ExPASy, EBI, Israel, Japan]
Munday N.A.,
Vaillancourt J.P.,
Ali A.,
Casano F.J.,
Miller D.K.,
Molineaux S.M.,
Yamin T.-T.,
Yu V.L.,
Nicholson D.W.;
"Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.";
J. Biol. Chem. 270:15870-15876(1995).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Thymus;
DOI=10.1074/jbc.270.25.15250; PubMed=7797510 [NCBI, ExPASy, EBI, Israel, Japan]
Kamens J.,
Paskind M.,
Hugunin M.,
Talanian R.V.,
Allen H.,
Banach D.,
Bump N.J.,
Hackett M.C.,
Johnston C.G.,
Li P.,
Mankovich J.A.,
Terranova M.,
Ghayur T.;
"Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.";
J. Biol. Chem. 270:15250-15256(1995).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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- FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
- CATALYTIC ACTIVITY: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.
- SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit (By similarity).
- INTERACTION:
P24941:CDK2; NbExp=1; IntAct=EBI-1057327, EBI-375096;
Q9NSA3:CTNNBIP1; NbExp=1; IntAct=EBI-1057327, EBI-747082;
P41091:EIF2S3; NbExp=1; IntAct=EBI-1057327, EBI-1054228;
P06396:GSN; NbExp=1; IntAct=EBI-1057327, EBI-351506;
Q86Y56:HEATR2; NbExp=1; IntAct=EBI-1057327, EBI-719966;
Q9Y241:HIGD1A; NbExp=1; IntAct=EBI-1057327, EBI-1051940;
O94874:KIAA0776; NbExp=1; IntAct=EBI-1057327, EBI-1048088;
P52701:MSH6; NbExp=1; IntAct=EBI-1057327, EBI-395529;
Q6UB35:MTHFD1L; NbExp=1; IntAct=EBI-1057327, EBI-1046835;
Q8N1F7:NUP93; NbExp=1; IntAct=EBI-1057327, EBI-1042703;
P20618:PSMB1; NbExp=1; IntAct=EBI-1057327, EBI-372273;
Q9H936:SLC25A22; NbExp=1; IntAct=EBI-1057327, EBI-1050588;
Q14683:SMC1A; NbExp=1; IntAct=EBI-1057327, EBI-80690;
Q9UQE7:SMC3; NbExp=1; IntAct=EBI-1057327, EBI-80718;
Q9Y5M8:SRPRB; NbExp=1; IntAct=EBI-1057327, EBI-355393;
Q9Y277:VDAC3; NbExp=1; IntAct=EBI-1057327, EBI-354196;
- TISSUE SPECIFICITY: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
- PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.
- SIMILARITY: Belongs to the peptidase C14 family [view classification].
- SIMILARITY: Contains 1 CARD domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 377 AA [This is the length of the unprocessed precursor] |
Molecular weight: 43262 Da [This is the MW of the unprocessed precursor] |
CRC64: DC7CCEC6E9D483EB [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT EDKVRVMADS
70 80 90 100 110 120
MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE
130 140 150 160 170 180
RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT
190 200 210 220 230 240
ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN
250 260 270 280 290 300
RNCLSLKDKP KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF
310 320 330 340 350 360
IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF ETPRAKAQMP
370
TIERLSMTRY FYLFPGN
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P49662 in FASTA format |
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ExPASy Home page
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