NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/s00335-004-2387-z; PubMed=15520886 [NCBI, ExPASy, EBI, Israel, Japan]
Roosen S., Exner K., Paul S., Schroder J.M., Kalm E., Looft C.;
"Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue.";
Mamm. Genome 15:834-842(2004).

[2]

PROTEIN SEQUENCE OF 23-60.
STRAIN=Hereford;
TISSUE=Neutrophil;
PubMed=8454635 [NCBI, ExPASy, EBI, Israel, Japan]
Selsted M.E., Tang Y.-Q., Morris W.L., McGuire P.A., Novotny M.J., Smith W., Henschen A.H., Cullor J.S.;
"Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.";
J. Biol. Chem. 268:6641-6648(1993).

Comments

FUNCTION: Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Neutrophilic granules.
SIMILARITY: Belongs to the beta-defensin family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ567992; CAD99423.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ567993; CAD99423.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

B47753; B47753.

3D structure databases

HSSP

P46170; 1BNB. [HSSP ENTRY / PDB]

ModBase

P46169.

Family and domain databases

InterPro

IPR001855; Defensin_beta.
IPR006080; Defensin_mammal.
Graphical view of domain structure.

Pfam

PF00711; Defensin_beta; 1.
Pfam graphical view of domain structure.

SMART

SM00048; DEFSN; 1.
SMART graphical view of domain structure.

BLOCKS

P46169.

Genome annotation databases

Ensembl

ENSBTAG00000033540; Bos taurus. [Contig view]

Phylogenomic databases

HOVERGEN

P46169; -.

Other

ProtoNet

P46169.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Defensin; Direct protein sequencing; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 22`	`22`
`PEPTIDE`	`23 60`	`38`	`Beta-defensin 11.`	`PRO_0000044726`
`DISULFID`	`27 56`		`By similarity.`
`DISULFID`	`34 49`		`By similarity.`
`DISULFID`	`39 57`		`By similarity.`

Sequence information

Length: 60 AA [This is the length of the unprocessed precursor]

Molecular weight: 6507 Da [This is the MW of the unprocessed precursor]

CRC64: 25D05BF218C166DE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRLHHLLLAL LFLVLSAGSG ISGPLSCRRN GGVCIPIRCP GPMRQIGTCF GRPVKCCRSW

P46169 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools