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UniProtKB/Swiss-Prot entry P36898


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BMR1B_MOUSE
Primary accession number P36898
Secondary accession number Q3TRF2
Integrated into Swiss-Prot on June 1, 1994
Sequence was last modified on June 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 86)
Name and origin of the protein
Protein name Bone morphogenetic protein receptor type-1B [Precursor]
Synonyms EC 2.7.11.30
Serine/threonine-protein kinase receptor R6
SKR6
Activin receptor-like kinase 6
ALK-6
CDw293 antigen
Gene name
Name: Bmpr1b
Synonyms: Acvrlk6
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8140412 [NCBI, ExPASy, EBI, Israel, Japan]
ten Dijke P., Yamashita H., Ichijo H., Franzen P., Laiho M., Miyazono K., Heldin C.-H.;
"Characterization of type I receptors for transforming growth factor-beta and activin.";
Science 264:101-104(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Head, and Hypothalamus;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6;
TISSUE=Brain, and Retina;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z23143; CAA80674.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK086130; BAC39617.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK162844; BAE37078.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065106; AAH65106.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC065143; AAH65143.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A53444; A53444.
RefSeq NP_031586.1; -.
UniGene Mm.39089
3D structure databases
HSSP P36897; 1IAS. [HSSP ENTRY / PDB]
ModBase P36898.
Protein-protein interaction databases
DIP DIP:252N; -.
Organism-specific databases
MGI MGI:107191; Bmpr1b.
Gene expression databases
ArrayExpress P36898; -.
CleanEx MM_BMPR1B; -.
GermOnline ENSMUSG00000052430; Mus musculus.
Ontologies
GO
GO:0005025; Molecular function: transforming growth factor beta receptor activity, type I (inferred from mutant phenotype from MGI).
GO:0030509; Biological process: BMP signaling pathway (inferred from mutant phenotype from MGI).
GO:0001502; Biological process: cartilage condensation (inferred from mutant phenotype from MGI).
GO:0009953; Biological process: dorsal/ventral pattern formation (inferred from genetic interaction from MGI).
GO:0006703; Biological process: estrogen biosynthetic process (non-traceable author statement from UniProtKB).
GO:0006954; Biological process: inflammatory response (inferred from expression pattern from UniProtKB).
GO:0001550; Biological process: ovarian cumulus expansion (inferred from mutant phenotype from UniProtKB).
GO:0060041; Biological process: retina development in camera-type eye (inferred from mutant phenotype from MGI).
GO:0031290; Biological process: retinal ganglion cell axon guidance (inferred from mutant phenotype from MGI).
GO:0007179; Biological process: transforming growth factor beta receptor signaling pathway (traceable author statement from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00467; GS; 1.
SMART graphical view of domain structure.
PROSITE PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS P36898.
Genome annotation databases
Ensembl ENSMUSG00000052430; Mus musculus. [Contig view]
GeneID 12167; -.
KEGG mmu:12167; -.
Phylogenomic databases
HOGENOM P36898; -.
HOVERGEN P36898; -.
Other
SOURCE Bmpr1b; Mus musculus.
ProtoNet P36898.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    13  13     Potential. 
CHAIN   14   502  489     Bone morphogenetic protein receptor type-1B. PRO_0000024413
TOPO_DOM   14   126  113     Extracellular (Potential). 
TRANSMEM   127   148  22     Potential. 
TOPO_DOM   149   502  354     Cytoplasmic (Potential). 
DOMAIN   174   203  30     GS. 
DOMAIN   204   494  291     Protein kinase. 
NP_BIND   210   218  9     ATP (By similarity). 
ACT_SITE   332   332        Proton acceptor (By similarity). 
BINDING   231   231        ATP (By similarity). 
Sequence information
Length: 502 AA [This is the length of the unprocessed precursor] Molecular weight: 56944 Da [This is the MW of the unprocessed precursor] CRC64: AB29681F3FF5A361 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 

        70         80         90        100        110        120 
DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKDRDFVD 

       130        140        150        160        170        180 
GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 

       190        200        210        220        230        240 
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 

       250        260        270        280        290        300 
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS 

       310        320        330        340        350        360 
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 

       370        380        390        400        410        420 
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 

       430        440        450        460        470        480 
EEYQLPYHDL VPSDPSYEDM REIVCMKKLR PSFPNRWSSD ECLRQMGKLM TECWAQNPAS 

       490        500 
RLTALRVKKT LAKMSESQDI KL 

P36898 in FASTA format

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View entry in raw text format (no links)
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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