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UniProtKB/Swiss-Prot entry P29767

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NANH_CLOSE
Primary accession number P29767
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1993
Sequence was last modified on April 1, 1993 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Sialidase [Precursor]
Synonyms EC 3.2.1.18
Neuraminidase
Gene name None
From
Clostridium septicum [TaxID: 1504] 
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NC 0054714;
DOI=10.1007/BF00273603; PubMed=2034213 [NCBI, ExPASy, EBI, Israel, Japan]
Rothe B., Rothe B., Roggentin P., Schauer R.;
"The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins.";
Mol. Gen. Genet. 226:190-197(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X63266; CAA44916.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S15994; NMCLSS.
3D structure databases
HSSP Q27701; 1SLL. [HSSP ENTRY / PDB]
ModBase P29767.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0004308; Molecular function: exo-alpha-sialidase activity (inferred from electronic annotation from InterPro).
GO:0005975; Biological process: carbohydrate metabolic process (inferred from electronic annotation from InterPro).
GO:0007155; Biological process: cell adhesion (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR002860; BNR.
IPR000421; Coagulation_factor_5/8-type_C.
IPR013320; ConA_like_subgrp.
IPR011490; FIVAR_sugar_bd.
IPR004124; Glyco_hydro_33_N.
Graphical view of domain structure.
Gene3D G3DSA:2.60.120.200; ConA_like_subgrp; 1.
Pfam PF02012; BNR; 4.
PF00754; F5_F8_type_C; 1.
PF07554; FIVAR; 1.
PF02973; Sialidase; 1.
Pfam graphical view of domain structure.
PROSITE PS50022; FA58C_3; 1.
PROSITE graphical view of domain structure (profiles).
Other
ProtoNet P29767.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycosidase; Hydrolase; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1     26  26     Potential. 
CHAIN   27   1014  988     Sialidase. PRO_0000012031
DOMAIN   39    186  148     F5/8 type C. 
REPEAT   431    442  12     BNR 1. 
REPEAT   563    574  12     BNR 2. 
REPEAT   627    638  12     BNR 3. 
REPEAT   700    711  12     BNR 4. 
ACT_SITE   421    421        Proton acceptor (By similarity). 
ACT_SITE   912    912        Nucleophile (By similarity). 
BINDING   396    396        Substrate (By similarity). 
BINDING   688    688        Substrate (By similarity). 
BINDING   873    873        Substrate (Potential). 
Sequence information
Length: 1014 AA [This is the length of the unprocessed precursor] Molecular weight: 110653 Da [This is the MW of the unprocessed precursor] CRC64: C4F49233473A2FAD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNKKKIMSIL VSAFLITNLS SNIIFADIKE NVYINQYSEG NRSQPIAEKL VPRSEIQASA 

        70         80         90        100        110        120 
TSALTGEGPE KAIDGNTSTL WHTPWAGVDI QINPQSLTLK LGKTRNISSI CVTPRQEGTN 

       130        140        150        160        170        180 
GMITDYKIYS GDDVIAEGKW KSDSSDKYVV FDNPISTDNI RIEAISTVGD ENNKHASIAE 

       190        200        210        220        230        240 
VEVYELADTP VKLAESNNKV INNGNGGNYE GDISEISLLE EGTAIIRFTN NGSSLFSISN 

       250        260        270        280        290        300 
NERTNEHFHV YINGGAIGYE LRKQSGNLAT GSVNKALNAG INTIAFKAEK GKGYSIYLNG 

       310        320        330        340        350        360 
EKILTSSSIT ANFLSTLEGL NTLSLGKTDR PSGSNEYNFT GEIDFFELYS KPLADRYLKE 

       370        380        390        400        410        420 
RTGETTSKDL PFPEGAVKTE PVDIFTPGEL GSNNFRIPAL YTTKDGTVLA SIDVRKGGGH 

       430        440        450        460        470        480 
DAPNNIDTGI KRSTDGGVTW DEGKIILDYP GASSAIDTSL LQDDETGRIF LIVTHFAEGY 

       490        500        510        520        530        540 
GFGNSKTGSG YVEIEGKRYL KLLGANDTIY TVREGVVYDS NGEATNYTVD NNNELYENGN 

       550        560        570        580        590        600 
RIGNVLLSNS PLKVMGTSFL SLIYSDDDGQ TWSDPIDLNK EVKTDWMRFL GTGPGKGHQI 

       610        620        630        640        650        660 
KTGRYAGRLL FPVYLTNASG FQSSAVIYSD DNGATWNIGE TATDGRLMDN GDRASAETIT 

       670        680        690        700        710        720 
TNTSGGVGQL TECQVVEMPN GQLKMFMRNT GGNSGRVRIA TSFDGGATWE DDVVRDENIK 

       730        740        750        760        770        780 
EPYCQLSVIN YSQKIDGKDA IIFAIPDANY PNRVNGTVRV GLITENGSYE NGEPRYDIEW 

       790        800        810        820        830        840 
RYNKVVAPGT YGYSCLSEMP NGEIGLFYEG RGSRQMSFTR MNIDYLKADL LQDVPAANIK 

       850        860        870        880        890        900 
SYTTNSENNI YDPGDKISLN VTFDQTVSLI GDRTITADIG GKEVLLTLAN SKGGSEYTFE 

       910        920        930        940        950        960 
GTVPADISNG NYTITIKGKS GLKIVNVVNK VTDITEDRNT GLNVQVGEEV QSVDKTLLQD 

       970        980        990       1000       1010 
LVDSTSNLIK EDYTEESWIL YEKALEVANK FLVNEIAVQE EVDAAKPTLE NAYK
P29767 in FASTA format

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