[1]
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NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND ACTIVE SITE.
DOI=10.1038/356768a0; PubMed=1574116 [NCBI, ExPASy, EBI, Israel, Japan]
Thornberry N.A.,
Bull H.G.,
Calaycay J.R.,
Chapman K.T.,
Howard A.D.,
Kostura M.J.,
Miller D.K.,
Molineaux S.M.,
Weidner J.R.,
Aunins J.,
Elliston K.O.,
Ayala J.M.,
Casano F.J.,
Chin J.,
Ding G.J.-F.,
Egger L.A.,
Gaffney E.P.,
Limjuco G.,
Palyha O.C., ![]()
Raju M.,
Rolando A.M.,
Salley J.P.,
Yamin T.-T.,
Lee T.D.,
Shively J.E.,
McCross M.,
Mumford R.A.,
Schmidt J.A.,
Tocci M.J.;
"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.";
Nature 356:768-774(1992).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE OF 120-142.
PubMed=1373520 [NCBI, ExPASy, EBI, Israel, Japan]
Cerretti D.P.,
Kozlosky C.J.,
Mosley B.,
Nelson N.,
van Ness K.,
Greenstreet T.A.,
March C.J.,
Kronheim S.R.,
Druck T.,
Cannizzaro L.A.,
Huebner K.,
Black R.A.;
"Molecular cloning of the interleukin-1 beta converting enzyme.";
Science 256:97-100(1992).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZETA), FUNCTION, MUTAGENESIS OF CYS-285, ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
DOI=10.1016/j.ygeno.2004.06.005; PubMed=15498465 [NCBI, ExPASy, EBI, Israel, Japan]
Feng Q.,
Li P.,
Leung P.C.K.,
Auersperg N.;
"Caspase-1 zeta, a new splice variant of caspase-1 gene.";
Genomics 84:587-591(2004).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
Totoki Y.,
Toyoda A.,
Takeda T.,
Sakaki Y.,
Tanaka A.,
Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-404 (ISOFORM BETA).
TISSUE=Testis;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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PROTEIN SEQUENCE OF 120-142.
DOI=10.1016/0003-9861(92)90629-B; PubMed=1321594 [NCBI, ExPASy, EBI, Israel, Japan]
Kronheim S.R.,
Mumma A.,
Greenstreet T.,
Glackin P.J.,
Van Ness K.,
March C.J.,
Black R.A.;
"Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursor.";
Arch. Biochem. Biophys. 296:698-703(1992).
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[7]
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ALTERNATIVE SPLICING, AND FUNCTION.
DOI=10.1074/jbc.270.9.4312; PubMed=7876192 [NCBI, ExPASy, EBI, Israel, Japan]
Alnemri E.S.,
Fernandes-Alnemri T.,
Litwack G.;
"Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities.";
J. Biol. Chem. 270:4312-4317(1995).
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[8]
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COMPONENT OF THE INFLAMMASOME.
DOI=10.1016/S1074-7613(04)00046-9; PubMed=15030775 [NCBI, ExPASy, EBI, Israel, Japan]
Agostini L.,
Martinon F.,
Burns K.,
McDermott M.F.,
Hawkins P.N.,
Tschopp J.;
"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.";
Immunity 20:319-325(2004).
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[9]
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INTERACTION WITH INCA.
DOI=10.1074/jbc.M407891200; PubMed=15383541 [NCBI, ExPASy, EBI, Israel, Japan]
Lamkanfi M.,
Denecker G.,
Kalai M.,
D'hondt K.,
Meeus A.,
Declercq W.,
Saelens X.,
Vandenabeele P.;
"INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.";
J. Biol. Chem. 279:51729-51738(2004).
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[10]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), AND SUBUNIT.
DOI=10.1016/0092-8674(94)90303-4; PubMed=8044845 [NCBI, ExPASy, EBI, Israel, Japan]
Walker N.P.C.,
Talanian R.V.,
Brady K.D.,
Dang L.C.,
Bump N.J.,
Ferenz C.R.,
Franklin S.,
Ghayur T.,
Hackett M.C.,
Hammill L.D.,
Herzog L.,
Hugunin M.,
Houy W.,
Mankovich J.A.,
McGuiness L.,
Orlewicz E.,
Paskind M.,
Pratt C.A.,
Reis P., ![]()
Summani A.,
Terranova M.,
Welch J.P.,
Xiong L.,
Moeller A.,
Tracey D.E.,
Kamen R.,
Wong W.W.;
"Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer.";
Cell 78:343-352(1994).
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[11]
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X-RAY CRYSTALLOGRAPHY (2.73 ANGSTROMS).
DOI=10.1016/S1074-5521(97)90258-1; PubMed=9190289 [NCBI, ExPASy, EBI, Israel, Japan]
Rano T.A.,
Timkey T.,
Peterson E.P.,
Rotonda J.,
Nicholson D.W.,
Becker J.W.,
Chapman K.T.,
Thornberry N.A.;
"A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE).";
Chem. Biol. 4:149-155(1997).
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[12]
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X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH INHIBITORS.
PubMed=9987822 [NCBI, ExPASy, EBI, Israel, Japan]
Okamoto Y.,
Anan H.,
Nakai E.,
Morihira K.,
Yonetoku Y.,
Kurihara H.,
Sakashita H.,
Terai Y.,
Takeuchi M.,
Shibanuma T.,
Isomura Y.;
"Peptide based interleukin-1 beta converting enzyme (ICE) inhibitors: synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex.";
Chem. Pharm. Bull. 47:11-21(1999).
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[13]
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X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 120-404 OF MUTANT ALA-285.
DOI=10.1016/j.str.2004.05.010; PubMed=15296730 [NCBI, ExPASy, EBI, Israel, Japan]
Romanowski M.J.,
Scheer J.M.,
O'Brien T.,
McDowell R.S.;
"Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.";
Structure 12:1361-1371(2004).
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