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UniProtKB/Swiss-Prot entry P26201

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CD36_BOVIN
Primary accession number P26201
Secondary accession numbers P79111 Q28154 Q3ZBT7
Integrated into Swiss-Prot on May 1, 1992
Sequence was last modified on January 23, 2007 (Sequence version 5)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Platelet glycoprotein 4
Synonyms Platelet glycoprotein IV
GPIV
GPIIIB
PAS IV
PAS-4
CD36 antigen
Gene name
Name: CD36
Synonyms: PAS4
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Holstein;
TISSUE=Mammary gland;
Hwangbo S., Ametani M., Kanno C.;
"cDNA cloning of PAS-4 from bovine fat globule membrane.";
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [MRNA], AND GLYCOSYLATION AT ASN-79; ASN-102; ASN-172; ASN-205; ASN-235; ASN-247; ASN-321 AND ASN-417.
TISSUE=Mammary gland;
DOI=10.1016/S0167-4781(96)00143-1; PubMed=8950178 [NCBI, ExPASy, EBI, Israel, Japan]
Berglund L., Petersen T.E., Ramussen J.T.;
"Structural characterization of bovine CD36 from the milk fat globule membrane.";
Biochim. Biophys. Acta 1309:63-68(1996).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Heart ventricle;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[4]
 PROTEIN SEQUENCE OF 2-22.
TISSUE=Heart;
PubMed=1697855 [NCBI, ExPASy, EBI, Israel, Japan]
Greenwalt D.E., Watt K.W.K., Hasler T., Howard R.J., Patel S.;
"Structural, functional, and antigenic differences between bovine heart endothelial CD36 and human platelet CD36.";
J. Biol. Chem. 265:16296-16299(1990).
[5]
 PROTEIN SEQUENCE OF 4-22 AND 214-223.
TISSUE=Mammary epithelium;
DOI=10.1021/bi00482a015; PubMed=1699598 [NCBI, ExPASy, EBI, Israel, Japan]
Greenwalt D.E., Watt K.W., So O.Y., Jiwani N.;
"PAS IV, an integral membrane protein of mammary epithelial cells, is related to platelet and endothelial cell CD36 (GP IV).";
Biochemistry 29:7054-7059(1990).
[6]
 DISULFIDE BONDS.
TISSUE=Milk;
PubMed=9826197 [NCBI, ExPASy, EBI, Israel, Japan]
Rasmussen J.T., Berglund L., Rasmussen M.S., Petersen T.E.;
"Assignment of disulfide bridges in bovine CD36.";
Eur. J. Biochem. 257:488-494(1998).
Comments
  • FUNCTION: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
  • SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
  • SIMILARITY: Belongs to the CD36 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D45364; BAA08224.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X91503; CAA62803.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC103112; AAI03113.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776435.1; -.
UniGene Bt.43948
3D structure databases
ModBase P26201.
PTM databases
GlycoSuiteDB P26201; -.
Family and domain databases
InterPro IPR002159; CD36.
IPR005428; CD36_antigen.
Graphical view of domain structure.
PANTHER PTHR11923; CD36; 1.
Pfam PF01130; CD36; 1.
Pfam graphical view of domain structure.
PRINTS PR01610; CD36ANTIGEN.
PR01609; CD36FAMILY.
BLOCKS P26201.
Genome annotation databases
Ensembl ENSBTAG00000017866; Bos taurus. [Contig view]
GeneID 281052; -.
KEGG bta:281052; -.
Phylogenomic databases
HOVERGEN P26201; -.
Other
ProtoNet P26201.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell adhesion; Direct protein sequencing; Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   472  471     Platelet glycoprotein 4. PRO_0000144150
TOPO_DOM   2     7  6     Cytoplasmic (Potential). 
TRANSMEM   8    29  22     Potential. 
TOPO_DOM   30   439  410     Extracellular (Potential). 
TRANSMEM   440   461  22     Potential. 
TOPO_DOM   462   472  11     Cytoplasmic (Potential). 
LIPID   3     3        S-palmitoyl cysteine (By similarity). 
LIPID   7     7        S-palmitoyl cysteine (By similarity). 
LIPID   464   464        S-palmitoyl cysteine (By similarity). 
LIPID   466   466        S-palmitoyl cysteine (By similarity). 
CARBOHYD   79    79        N-linked (GlcNAc...). 
CARBOHYD   102   102        N-linked (GlcNAc...). 
CARBOHYD   172   172        N-linked (GlcNAc...). 
CARBOHYD   205   205        N-linked (GlcNAc...). 
CARBOHYD   235   235        N-linked (GlcNAc...). 
CARBOHYD   247   247        N-linked (GlcNAc...). 
CARBOHYD   321   321        N-linked (GlcNAc...). 
CARBOHYD   417   417        N-linked (GlcNAc...). 
DISULFID   243   311         
DISULFID   272   333         
DISULFID   313   322         
CONFLICT   39    39        K -> N (in Ref. 2; CAA62803). 
CONFLICT   110   110        H -> N (in Ref. 1; BAA08224). 
CONFLICT   125   125        S -> L (in Ref. 1; BAA08224). 
CONFLICT   134   134        T -> K (in Ref. 1; BAA08224). 
CONFLICT   257   257        F -> L (in Ref. 1; BAA08224). 
CONFLICT   294   294        I -> V (in Ref. 1; BAA08224). 
CONFLICT   305   305        Q -> E (in Ref. 1; BAA08224). 
CONFLICT   359   359        S -> G (in Ref. 1; BAA08224). 
CONFLICT   391   396        MLVKPA -> TGQARQ (in Ref. 1; BAA08224). 
CONFLICT   466   466        C -> Y (in Ref. 1; BAA08224). 
CONFLICT   470   472        RVN -> TIK (in Ref. 1; BAA08224). 
Sequence information
Length: 472 AA [This is the length of the unprocessed precursor] Molecular weight: 52940 Da [This is the MW of the unprocessed precursor] CRC64: D864D6D3D6E8622F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGCNRNCGLI AGAVIGAVLA VFGGILMPVG DMLIEKTIKK EVVLEEGTIA FKNWVKTGTD 

        70         80         90        100        110        120 
VYRQFWIFDV QNPDEVTVNS SKIKVKQRGP YTYRVRYLAK ENITQDPETH TVSFLQPNGA 

       130        140        150        160        170        180 
IFEPSLSVGT EDDTFTILNL AVAAAPQLYP NTFMQGILNS FIKKSKSSMF QNRTLKELLW 

       190        200        210        220        230        240 
GYTDPFLNLV PYPITTTIGV FYPYNNTADG IYKVFNGKDD ISKVAIIDTY KGRKNLSYWS 

       250        260        270        280        290        300 
SYCDLINGTD AASFPPFVEK TRVLQFFSSD ICRSIYAVFG AEINLKGIPV YRFILPSFAF 

       310        320        330        340        350        360 
ASPFQNPDNH CFCTEKIISK NCTLYGVLDI GKCKEGKPVY ISLPHFLHGS PELAEPIESL 

       370        380        390        400        410        420 
SPNEEEHSTY LDVEPITGFT LRFAKRLQVN MLVKPAKKIE ALKNLKHNYI VPILWLNETG 

       430        440        450        460        470 
TIGDEKAEMF RNQVTGKINL LGLVEIVLLS VGVVMFIAFM ISYCACRSKR VN
P26201 in FASTA format

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