[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1714386 [NCBI, ExPASy, EBI, Israel, Japan]
Elledge S.J.,
Spottswood M.R.;
"A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.";
EMBO J. 10:2653-2659(1991).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/353174a0; PubMed=1653904 [NCBI, ExPASy, EBI, Israel, Japan]
Tsai L.-H.,
Harlow E.,
Meyerson M.;
"Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.";
Nature 353:174-177(1991).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1717994 [NCBI, ExPASy, EBI, Israel, Japan]
Ninomiya-Tsuji J.,
Nomoto S.,
Yasuda H.,
Reed S.I.,
Matsumoto K.;
"Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.";
Proc. Natl. Acad. Sci. U.S.A. 88:9006-9010(1991).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Rieder M.J.,
Livingston R.J.,
Braun A.C.,
Montoya M.A.,
Chung M.-W.,
Miyamoto K.E.,
Nguyen C.P.,
Nguyen D.A.,
Poel C.L.,
Robertson P.D.,
Schackwitz W.S.,
Sherwood J.K.,
Witrak L.A.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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PHOSPHORYLATION AT THR-14; TYR-15 AND THR-160, AND MUTAGENESIS OF THR-14; TYR-15 AND THR-160.
PubMed=1396589 [NCBI, ExPASy, EBI, Israel, Japan]
Gu Y.,
Rosenblatt J.,
O'Morgan D.O.;
"Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.";
EMBO J. 11:3995-4005(1992).
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[8]
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INTERACTION WITH CCNB3.
DOI=10.1074/jbc.M203951200; PubMed=12185076 [NCBI, ExPASy, EBI, Israel, Japan]
Nguyen T.B.,
Manova K.,
Capodieci P.,
Lindon C.,
Bottega S.,
Wang X.-Y.,
Refik-Rogers J.,
Pines J.,
Wolgemuth D.J.,
Koff A.;
"Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.";
J. Biol. Chem. 277:41960-41969(2002).
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[9]
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INTERACTION WITH SPDYA.
DOI=10.1083/jcb.200109045; PubMed=11980914 [NCBI, ExPASy, EBI, Israel, Japan]
Porter L.A.,
Dellinger R.W.,
Tynan J.A.,
Barnes E.A.,
Kong M.,
Lenormand J.-L.,
Donoghue D.J.;
"Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.";
J. Cell Biol. 157:357-366(2002).
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[10]
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INTERACTION WITH SPDYA.
PubMed=12839962 [NCBI, ExPASy, EBI, Israel, Japan]
Barnes E.A.,
Porter L.A.,
Lenormand J.-L.,
Dellinger R.W.,
Donoghue D.J.;
"Human Spy1 promotes survival of mammalian cells following DNA damage.";
Cancer Res. 63:3701-3707(2003).
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[11]
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INTERACTION WITH SPDYA, AND IDENTIFICATION IN A COMPLEX WITH CDKN1B AND SPDYA.
DOI=10.1091/mbc.E02-12-0820; PubMed=12972555 [NCBI, ExPASy, EBI, Israel, Japan]
Porter L.A.,
Kong-Beltran M.,
Donoghue D.J.;
"Spy1 interacts with p27Kip1 to allow G1/S progression.";
Mol. Biol. Cell 14:3664-3674(2003).
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[12]
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INTERACTION WITH UHRF2, AND IDENTIFICATION IN A COMPLEX WITH UHRF2 AND CCNE1.
DOI=10.1016/j.bbrc.2004.04.190; PubMed=15178429 [NCBI, ExPASy, EBI, Israel, Japan]
Li Y.,
Mori T.,
Hata H.,
Homma Y.,
Kochi H.;
"NIRF induces G1 arrest and associates with Cdk2.";
Biochem. Biophys. Res. Commun. 319:464-468(2004).
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[13]
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PHOSPHORYLATION AT THR-160.
DOI=10.1074/jbc.M309995200; PubMed=14597612 [NCBI, ExPASy, EBI, Israel, Japan]
Liu Y.,
Wu C.,
Galaktionov K.;
"p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.";
J. Biol. Chem. 279:4507-4514(2004).
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[14]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[15]
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INTERACTION WITH SPDYA AND SPDYC.
PubMed=15611625 [NCBI, ExPASy, EBI, Israel, Japan]
Cheng A.,
Xiong W.,
Ferrell J.E. Jr.,
Solomon M.J.;
"Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.";
Cell Cycle 4:155-165(2005).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND TYR-19, AND MASS SPECTROMETRY.
TISSUE=Lung;
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[17]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; TYR-15; TYR-19 AND THR-160, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.T600062-MCP200; PubMed=17192257 [NCBI, ExPASy, EBI, Israel, Japan]
Wissing J.,
Jaensch L.,
Nimtz M.,
Dieterich G.,
Hornberger R.,
Keri G.,
Wehland J.,
Daub H.;
"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.";
Mol. Cell. Proteomics 6:537-547(2007).
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[18]
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X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
DOI=10.1038/363595a0; PubMed=8510751 [NCBI, ExPASy, EBI, Israel, Japan]
de Bondt H.L.,
Rosenblatt J.,
Jancarik J.,
Jones H.D.,
Morgan D.O.,
Kim S.-H.;
"Crystal structure of cyclin-dependent kinase 2.";
Nature 363:595-602(1993).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF COMPLEX WITH CYCLIN A.
DOI=10.1038/376313a0; PubMed=7630397 [NCBI, ExPASy, EBI, Israel, Japan]
Jeffrey P.D.,
Russo A.A.,
Polyak K.,
Gibbs E.,
Hurwitz J.,
Massague J.,
Pavletich N.P.;
"Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.";
Nature 376:313-320(1995).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITG CKS1.
DOI=10.1016/S0092-8674(00)81065-X; PubMed=8601310 [NCBI, ExPASy, EBI, Israel, Japan]
Bourne Y.,
Watson M.H.,
Hickey M.J.,
Holmes W.,
Rocque W.,
Reed S.I.,
Tainer J.A.;
"Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.";
Cell 84:863-874(1996).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
DOI=10.1021/jm960402a; PubMed=8917641 [NCBI, ExPASy, EBI, Israel, Japan]
Schulze-Gahmen U.,
de Bondt H.L.,
Kim S.-H.;
"High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.";
J. Med. Chem. 39:4540-4546(1996).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF COMPLEX WITH CG2A AND KIP1.
DOI=10.1038/382325a0; PubMed=8684460 [NCBI, ExPASy, EBI, Israel, Japan]
Russo A.A.,
Jeffrey P.D.,
Patten A.K.,
Massague J.,
Pavletich N.P.;
"Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.";
Nature 382:325-331(1996).
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[23]
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X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF COMPLEX WITH CG2A.
DOI=10.1038/nsb0896-696; PubMed=8756328 [NCBI, ExPASy, EBI, Israel, Japan]
Russo A.A.,
Jeffrey P.D.,
Pavletich N.P.;
"Structural basis of cyclin-dependent kinase activation by phosphorylation.";
Nat. Struct. Biol. 3:696-700(1996).
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[24]
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X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF COMPLEX WITH L868276.
DOI=10.1073/pnas.93.7.2735; PubMed=8610110 [NCBI, ExPASy, EBI, Israel, Japan]
de Azevedo W.F. Jr.,
Mueller-Dieckmann H.-J.,
Schulze-Gahmen U.,
Worland P.J.,
Sausville E.,
Kim S.-H.;
"Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.";
Proc. Natl. Acad. Sci. U.S.A. 93:2735-2740(1996).
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[25]
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X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
DOI=10.1038/nsb1097-796; PubMed=9334743 [NCBI, ExPASy, EBI, Israel, Japan]
Lawrie A.M.,
Noble M.E.M.,
Tunnah P.,
Brown N.R.,
Johnson L.N.,
Endicott J.A.;
"Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.";
Nat. Struct. Biol. 4:796-801(1997).
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[26]
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X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
DOI=10.1126/science.281.5376.533; PubMed=9677190 [NCBI, ExPASy, EBI, Israel, Japan]
Gray N.S.,
Wodicka L.,
Thunnissen A.-M.W.H.,
Norman T.C.,
Kwon S.,
Espinoza F.H.,
Morgan D.O.,
Barnes G.,
Leclerc S.,
Meijer L.,
Kim S.H.,
Lockhart D.J.,
Schultz P.G.;
"Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.";
Science 281:533-538(1998).
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[27]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 1-288 IN COMPLEX WITH CCNB1, AND FUNCTION.
PubMed=17495531 [NCBI, ExPASy, EBI, Israel, Japan]
Brown N.R.,
Lowe E.D.,
Petri E.,
Skamnaki V.,
Antrobus R.,
Johnson L.N.;
"Cyclin B and cyclin A confer different substrate recognition properties on CDK2.";
Cell Cycle 6:1350-1359(2007).
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[28]
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VARIANTS [LARGE SCALE ANALYSIS] LEU-45 AND SER-290.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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