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UniProtKB/Swiss-Prot entry P24322


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GGPPS_NEUCR
Primary accession number P24322
Secondary accession numbers Q7RVC0 Q86ZV1
Integrated into Swiss-Prot on March 1, 1992
Sequence was last modified on January 15, 2008 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 76)
Name and origin of the protein
Protein name Geranylgeranyl pyrophosphate synthetase
Synonyms GGPP synthetase
GGPPSase
Geranylgeranyl diphosphate synthase
Albino-3 protein
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Farnesyltranstransferase
     (EC 2.5.1.29)
Gene name
Name: al-3
ORFNames: B8P8.010, NCU01427
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=1826006 [NCBI, ExPASy, EBI, Israel, Japan]
Carattoli A., Romano N., Ballario P., Morelli G., Macino G.;
"The Neurospora crassa carotenoid biosynthetic gene (albino 3) reveals highly conserved regions among prenyltransferases.";
J. Biol. Chem. 266:5854-5859(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan]
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-134, AND ALTERNATIVE INITIATION.
PubMed=7929398 [NCBI, ExPASy, EBI, Israel, Japan]
Vittorioso P., Carattoli A., Londei P., Macino G.;
"Internal translational initiation in the mRNA from the Neurospora crassa albino-3 gene.";
J. Biol. Chem. 269:26650-26654(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U20940; AAC13867.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX294018; CAD70868.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000014; EAA31459.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
S74011; AAP21085.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S15662; S15662.
RefSeq XP_960695.2; -.
3D structure databases
ModBase P24322.
Enzyme and pathway databases
BioCyc NCRA-XX3-01:NCRA-XX3-01-005137-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0005625; Cellular component: soluble fraction (inferred from sequence or structural similarity from UniProtKB).
GO:0004161; Molecular function: dimethylallyltranstransferase activity (inferred from electronic annotation from EC).
GO:0004311; Molecular function: farnesyltranstransferase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0004337; Molecular function: geranyltranstransferase activity (inferred from electronic annotation from EC).
GO:0016117; Biological process: carotenoid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
PANTHER PTHR12001; Polyprenyl_synt; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
ProtoNet P24322.
Genome annotation databases
GeneID 3876842; -.
KEGG ncr:NCU01427; -.
NMPDR fig|5141.1.peg.4853; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative initiation; Carotenoid biosynthesis; Complete proteome; Cytoplasm; Isoprene biosynthesis; Multifunctional enzyme; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   433  433     Geranylgeranyl pyrophosphate synthetase. PRO_0000123966
ACT_SITE   273   273        By similarity. 
VAR_SEQ   1    98        Missing (in isoform 3). VSP_029973
VAR_SEQ   1    88        Missing (in isoform 2). VSP_029974
Sequence information
Length: 433 AA [This is the length of the unprocessed precursor] Molecular weight: 48485 Da [This is the MW of the unprocessed precursor] CRC64: BE6BB03A938BDFA5 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEHVTMAVTS SSPGPAPLSL LSNNDDFIAP FNINTKFPSA IVPPRTSSNQ PISVAIPSNR 

        70         80         90        100        110        120 
ISSAGLAATQ QAQTRKRKAS VAQISLPSML PTSFSPYTMA PQPPQPPPNP DRFATEDFFS 

       130        140        150        160        170        180 
PSRRTWSEEK EKVLTGPYDY LNGHPGKDIR SQMVKAFDAW LDVPSESLEV ITKVISMLHT 

       190        200        210        220        230        240 
ASLLVDDVED NSVLRRGFPV AHSIFGIPQT INTSNYVYFY ALQELQKLKN PKAVSIFSEE 

       250        260        270        280        290        300 
LLNLHRGQGM DLFWRDTLTC PTEDDYLEMV SNKTGGLFRL GIKLMQAESR SPVDCVPLVN 

       310        320        330        340        350        360 
IIGLIFQIAD DYHNLWNREY TANKGMCEDL TEGKFSFPVI HSIRSNPSNM QLLNILKQKT 

       370        380        390        400        410        420 
GDEEVKRYAV AYMESTGSFE YTRKVIKVLV DRARQMTEDI DDGRGKSGGI HKILDRIMLH 

       430 
QEENVAQKNG KKE 

P24322 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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