[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE. STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; PubMed=2145270 [NCBI, ExPASy, EBI, Israel, Japan] Niedermann D.M., Lerch K.; "Molecular cloning of the L-amino-acid oxidase gene from Neurospora crassa."; J. Biol. Chem. 265:17246-17251(1990).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; DOI=10.1093/nar/gkg293; PubMed=12655011 [NCBI, ExPASy, EBI, Israel, Japan] Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.; "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."; Nucleic Acids Res. 31:1944-1954(2003).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan] Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; "The genome sequence of the filamentous fungus Neurospora crassa."; Nature 422:859-868(2003).

Comments

CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD.
INDUCTION: By addition of L-amino acids after nitrogen starvation, by starvation in phosphate buffer and by the addition of protein synthesis inhibitors, D-amino acids, or ATP.
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AL670007; CAD21325.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000015; EAA32442.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A38314; A38314.

RefSeq

XP_961678.1; -.

3D structure databases

ModBase

P23623.

Enzyme and pathway databases

BioCyc

NCRA-XX3-01:NCRA-XX3-01-004776-MON; -.

Ontologies

GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0001716;	Molecular function: L-amino-acid oxidase activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

ProtoNet

P23623.

Genome annotation databases

GeneID

3877869; -.

KEGG

ncr:NCU01066; -.

NMPDR

fig|5141.1.peg.4492; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Oxidoreductase; Zymogen.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`PROPEP`	`1 130`	`130`		`PRO_0000001708`
`CHAIN`	`131 696`	`566`	`L-amino-acid oxidase.`	`PRO_0000001709`
`NP_BIND`	`236 237`	`2`	`FAD (By similarity).`
`NP_BIND`	`658 661`	`4`	`FAD (By similarity).`
`BINDING`	`207 207`		`FAD (By similarity).`
`BINDING`	`215 215`		`FAD (By similarity).`
`BINDING`	`237 237`		`Substrate (By similarity).`
`BINDING`	`440 440`		`FAD; via amide nitrogen and carbonyl oxygen (By similarity).`
`BINDING`	`564 564`		`Substrate (By similarity).`
`BINDING`	`649 649`		`FAD (By similarity).`
`CONFLICT`	`6 13`		`AAGAALLA -> RGCGTAR (in Ref. 1; AA sequence).`
`CONFLICT`	`53 53`		`I -> L (in Ref. 1; AA sequence).`
`CONFLICT`	`343 343`		`F -> L (in Ref. 1; AA sequence).`
`CONFLICT`	`391 414`		`SASAHSYWDTLYEGMYFSASTWKT -> APALTRTGTRCTKGCTFPRRRGA (in Ref. 1; AA sequence).`
`CONFLICT`	`440 440`		`V -> L (in Ref. 1; AA sequence).`
`CONFLICT`	`684 685`		`AT -> GRP (in Ref. 1; AA sequence).`

Sequence information

Length: 696 AA [This is the length of the unprocessed precursor]

Molecular weight: 77013 Da [This is the MW of the unprocessed precursor]

CRC64: 3909C59198E96008 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKWSAAAGAA LLALPANSAV TASLPLKLET RSSLNSRLSN IHVERSASVE GAISYTYGSC 

        70         80         90        100        110        120 
QAKREEEAHH SISQPTDAHH DRLVWVIPEN VQSGGCISAW SRANGRLVGR SRPQSFDFKS 

       130        140        150        160        170        180 
IKMRRDLKAR ATKPSDSVAI HMTTDNGINP WGPWFDGVKL LEDKEISTVD VEKAKSKNIA 

       190        200        210        220        230        240 
IVGAGMSGLM TYLCLTQAGM TNVSIIEGGN RLGGRVHTEY LSGGPFDYSY QEMGPMRFPN 

       250        260        270        280        290        300 
TITLGNETYN VSDHQLVFQL AEEMNSLNGH SKNLSVDFIP WYQSNSNGLY YYDGIKNPET 

       310        320        330        340        350        360 
GLPPTLAELA ANSSLALTRV SNNSTKSLSQ KVDAFLPDTD KFFAEMAQNM FKAHADWLSG 

       370        380        390        400        410        420 
GLAGLPGDQW SEFGFMVNYL RGSLNDTAFL SASAHSYWDT LYEGMYFSAS TWKTIDGGLN 

       430        440        450        460        470        480 
RLPLSFHPLV DNATTLNRRV ERVAFDAETQ KVTLHSRNSY KDSFESSEHD YAVIAAPFSI 

       490        500        510        520        530        540 
VKKWRFSPAL DLTAPTLANA IQNLEYTSAC KVALEFRTRF WEHLPQPIYG SCSTTSDIPG 

       550        560        570        580        590        600 
IGSICYPSYN INGTDGPASI LASYISGADW GDRWVSTPEE EHVQYVLNAM AEIHGEELVK 

       610        620        630        640        650        660 
EQYTGQFNRR CWALDPLESA SWASPTVGQH ELYLPEYFQT RNNLVFVGEH TSYTHAWIAS 

       670        680        690 
ALESGIRGSV QLLLELGLVD EAKATVDKWM ARWIDV

P23623 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools